Abstract: Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of IDO, syntheses, and uses thereof are provided.

Abstract: A PD-L1 nano-antibody and a PD-L2 nano-antibody, and a bispecific antibody having both the PD-L1 nano-antibody and the PD-L2 nano-antibody are disclosed. The bispecific antibody can block PD-1/PD-L1 and PD-1/PD-L2 pathways at the same time. The bispecific antibody can reactivate T cells, enhance immune responses, and more effectively improve the inhibitory effect on tumor occurrence and development.

Abstract: A table tool includes a table, a saw blade, a motor, a controller, a sensing device and a first switch. The table has a work plane on which a workpiece is placed. The saw blade acts on the workpiece. The motor drives the saw blade to rotate. The controller is used for controlling rotation of the motor. The sensing device is electrically connected to the controller and used for sensing a state of the workpiece and outputting a first signal to the controller. The first switch is used for a user to select a working mode from at least two working modes of the table tool. When the table tool is in a first working mode, the controller is configured to adjust a rotational speed of the motor to be a first rotational speed based on an acquired first signal or a working parameter of the motor.

Abstract: A method for image processing is provided. The method includes: capturing and receiving a first set of photo frames; storing the first set of photo frames into a storage unit; performing image processing on the first set of photo frames; and capturing and receiving a second set of photo frames. The performing image processing on the first set of photo frames and the capturing and receiving the second set of photo frames are performed simultaneously. The performing image processing on the first set of photo frames includes: reading the first set of photo frames from the storage unit; storing the first set of photo frames into a temporary storage unit; performing image processing on the first set of photo frames by using an image processing algorithm; and outputting a first output picture.

Abstract: Provided are a multimedia data processing method, a multimedia data generation method, and a related device, which relate to the technical field of computers. The processing method comprises: acquiring multimedia data; displaying an editing page, wherein the editing page displays material data in the multimedia data; in response to a marking operation being carried out on at least one piece of material data, marking the at least one piece of material data; and in response to a template generation instruction, removing the marked material data from the multimedia data and generating a template.

Abstract: An enclosure surrounding the optical component can be connected with a vapor source. The vapor source can provide a vapor to the enclosure with a vapor level from 500 ppm to 15000 ppm. The concentration of vapor in the enclosure can increase the lifespan of the optical component in the enclosure.

Abstract: An in-air gesture control method based on visible light signals, which transmits light signals through a display device and collects its light signals reflected by hand, and after analysis, realizes gesture recognition; the transmitted light signals are in the visible light band; which can realize the gesture recognition and control on mobile devices without modifying hardware and a visible light-based gesture recognition system on commercial mobile devices; compared with the existing gesture recognition methods on commercial mobile devices, the invention avoids special hardware modification, that is, it does not require any additional components on the mobile device, such as a depth camera, and protects the user's privacy well.

Abstract: The present invention belongs to the field of medicinal chemistry. Specifically disclosed is a class of URAT1 inhibitors for promoting uric acid excretion, which are compounds as represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on the transport of uric acid by hURAT1 in HEK293 transfected cells, and that such compounds have a good application prospect in the treatment of hyperuricemia or gout.

Abstract: Disclosed is the use of a checkpoint kinase (CHK) inhibitor in combination with i) a poly(ADP)-ribose polymerase inhibitor, and optionally ii) a chemotherapeutic agent such as gemcitabine, in cancer treatment.

Abstract: Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of Formula (Ia) and (Ib) of IDO, their synthesis, and uses thereof are provided.

Abstract: The present disclosure provides an electronic device. The electronic device includes a display module having a grounding element disposed under the display module and an antenna pattern. The grounding element is configured to function as a reference ground of the antenna pattern. A wearable device is also provided.

Abstract: Provided are a beauty processing method and apparatus. The method includes: obtaining an original face image, and extracting original parameter information corresponding to a site feature of a to-be-beautified site; determining, based on the original parameter information, a site beauty parameter corresponding to the to-be-beautified site; and processing the to-be-beautified site based on the site beauty parameter to generate a target face image. Thus, the personalized beauty parameters can be generated to meet the user's personalized beauty needs, improving the accuracy of the beauty parameter and enhancing the beauty effect.

Abstract: A neural network accelerator includes a first memory device, a controller connected to the first memory device through a high-bandwidth (e.g., three-dimensional) interconnect, a configurable processing element (PE) array connected to the first memory device through a first data bus and including a two-dimensional (2D) array of PEs, a local memory connected to the controller and connected, through a second data bus, to the configurable PE array. The controller is configured to, during execution of a neural network (NN), dynamically configure the neural network accelerator for executing each NN layer of a plurality of NN layers of the neural network by selecting either weights of a weight tensor or input data of an input tensor of a tensor operation of the NN layer to store into the local memory, and configuring input and output connections of PEs in the 2D array of PEs for performing the tensor operation.

Abstract: At least some embodiments of the present disclosure relate to a wearable device. The wearable device comprises a substrate, a detecting module disposed on the substrate, and a control module disposed on the substrate. The control module is electrically connected to the detecting module. The control module is configured to receive a signal from the detecting module and to control the wearable device in response to the signal.

Abstract: Provided herein are methods of using (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, a mixture of enantiomers, a tautomer, an isotopolog, or a pharmaceutically acceptable salt thereof, in combination with tafasitamab, obinutuzumab, or tazemetostat, for treating, preventing or managing non-Hodgkin lymphoma.

Abstract: A method, computer program product, and computer system for processing instances of message sequences. Two or more instances are received. Each instance has an instance number and an associated instance Id. Each instance includes a stream of one or more messages. Each message in each stream is associated with a respective task. All messages in the two or more instances whose respective tasks have been completed are distributed into partitions in the broker. Different messages in each instance of at least one instance are distributed into different partitions. The messages distributed in the partitions include parallel task messages. The parallel task messages are sequenced by being grouped by the instance number or instance Id and are sequentially ordered in each group in an ascending order of a timestamp of arrival of each parallel task message at the broker. The parallel task messages in each instance are dispatched to a service.

Abstract: The present disclosure provides an electronic device. The electronic device includes a display module having a grounding element disposed under the display module and an antenna pattern. The grounding element is configured to function as a reference ground of the antenna pattern. A wearable device is also provided.

Abstract: A stator winding includes a plurality of conductors including ducts. The ducts can be connected to a heat pipe or a conduit providing a coolant flow to directly cool the winding. The heat pipe can be connected to a heat exchanger that includes a coolant flow. The stator winding can be produced using additive manufacturing, with hollow ducts extending through leg sections and solid end sections. The heat exchanger can also be additively manufactured. A circuit for driving an electrical machine can be in thermal communication with the heat exchanger, such that the thermal system manages both the stators and the drive circuit.

Abstract: The present application relates to a global communication management entity for managing vehicle-to-everything (V2X) communication parameters of a plurality of vehicular user equipments of a V2X communication network, the corresponding V2X communication network and vehicular user equipment.