Abstract: Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating autoimmune and/or glomerulonephritis-associated diseases, and in particular, Systemic Lupus Erythematosus (SLE).

Abstract: Inhibitors of protein tyrosine phosphatases are disclosed. The inhibitors include hydroxyindole carboxylic acids having a linker and an amine scaffold that are potent inhibitors of Src homology 2-domain containing protein tyrosine phosphatase-2.

Abstract: A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological pH and have good bioavailability characteristics. These compounds exhibit selective or at least preferential affinity for the active sites of various sub-sets of protein tyrosine phosphatases. Some of these compounds are excellent inhibitors of Mycobacterium protein tyrosine phosphatase B (mPTPB) a protein tyrosine phosphatase expressed in Mycobacterium tuberculosis and characterized as a virulence factor in the causal agent of tuberculosis. Accordingly, many of these compounds and pharmaceutically acceptable salts thereof are useful for the treatment of diseases such as tuberculosis.

Abstract: Unique apparatuses, systems, methods, and techniques for control of engine systems are disclosed. One embodiment is a unique controls process providing engine start/stop functionality. In one form, the controls process includes engine stop controls which evaluate a plurality of engine stop request conditions and a plurality of engine stop capability conditions, as well as engine start controls which evaluate a plurality of engine start request conditions and a plurality of engine start capability conditions.

Abstract: An engine starting system and technique include selecting a target engine speed profile from a plurality of engine speed profiles based on operator inputs and operating parameters of the vehicle. A feedback control strategy is used to substantially conform the engine speed with the target speed profile during starting until a target speed is reached in which fueling is initiated to start the engine.

Abstract: Inhibitors of protein tyrosine phosphatases are disclosed. The inhibitors include hydroxyindole carboxylic acids having a linker and an amine scaffold that are potent inhibitors of Src homology 2-domain containing protein tyrosine phosphatase-2.

Abstract: An exhaust aftertreatment system includes an oxidation catalyst and a selective catalytic reduction (SCR) catalyst disposed in an exhaust stream of an internal combustion engine. A stay warm thermal management strategy is employed after warm-up of the aftertreatment system is complete to maintain the aftertreatment system above a temperature providing a desired performance threshold of one or more components of the aftertreatment system, such as the oxidation catalyst or the SCR catalyst.

Abstract: A method and system for mitigating a urea deposit within an SCR system that includes determining a mass of an accumulated urea deposit present within the SCR catalyst and SCR piping, comparing the mass of the accumulated urea deposit with a deposit upper threshold limit, and initiating an SCR regeneration event when the mass of the accumulated urea deposit is greater than the deposit upper threshold limit. The method further includes determining an amount of NH3 passing through the SCR catalyst downstream of the urea deposit, comparing the amount of NH3 passing through the SCR catalyst with an NH3 regeneration threshold limit, and terminating the SCR regeneration event when the level of NH3 passing through the SCR catalyst is less than the SCR NH3 regeneration threshold.

Abstract: Unique apparatuses, systems, methods, and techniques for control of engine systems are disclosed. One embodiment is a unique controls process providing engine start/stop functionality. In one form, the controls process includes engine stop controls which evaluate a plurality of engine stop request conditions and a plurality of engine stop capability conditions, as well as engine start controls which evaluate a plurality of engine start request conditions and a plurality of engine start capability conditions.

Abstract: An engine starting system and technique include selecting a target engine speed profile from a plurality of engine speed profiles based on operator inputs and operating parameters of the vehicle. A feedback control strategy is used to substantially conform the engine speed with the target speed profile during starting until a target speed is reached in which fueling is initiated to start the engine.

Abstract: A method and system for mitigating a urea deposit within an SCR system that includes determining a mass of an accumulated urea deposit present within the SCR catalyst and SCR piping, comparing the mass of the accumulated urea deposit with a deposit upper threshold limit, and initiating an SCR regeneration event when the mass of the accumulated urea deposit is greater than the deposit upper threshold limit. The method further includes determining an amount of NH3 passing through the SCR catalyst downstream of the urea deposit, comparing the amount of NH3 passing through the SCR catalyst with an NH3 regeneration threshold limit, and terminating the SCR regeneration event when the level of NH3 passing through the SCR catalyst is less than the SCR NH3 regeneration threshold.

Abstract: An exhaust aftertreatment system includes an oxidation catalyst and a selective catalytic reduction (SCR) catalyst disposed in an exhaust stream of an internal combustion engine. A stay warm thermal management strategy is employed after warm-up of the aftertreatment system is complete to maintain the aftertreatment system above a temperature providing a desired performance threshold of one or more components of the aftertreatment system, such as the oxidation catalyst or the SCR catalyst.

Abstract: A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological pH and have good bioavailability characteristics. These compounds exhibit selective or at least preferential affinity for the active sites of various sub-sets of protein tyrosine phosphatases. Some of these compounds are excellent inhibitors of Mycobacterium protein tyrosine phosphatase B (mPTPB) a protein tyrosine phosphatase expressed in Mycobacterium tuberculosis and characterized as a virulence factor in the causal agent of tuberculosis. Accordingly, many of these compounds and pharmaceutically acceptable salts thereof are useful for the treatment of diseases such as tuberculosis.

Abstract: Described herein is a microchannel that is formed beneath and parallel to a surface of a silicon substrate. Silicon migration technology is utilized to form a microchannel that is buried beneath the surface of the silicon substrate. Etching opens at least one end of the microchannel. Oxidization is utilized through the open end of the microchannel to facilitate a controlled diameter of the microchannel.

Abstract: An engine starting system and technique include selecting a target engine speed profile from a plurality of engine speed profiles based on operator inputs and operating parameters of the vehicle. A feedback control strategy is used to substantially conform the engine speed with the target speed profile during starting until a target speed is reached in which fueling is initiated to start the engine.

Abstract: A method and system for mitigating a urea deposit within an SCR system that includes determining a mass of an accumulated urea deposit present within the SCR catalyst and SCR piping, comparing the mass of the accumulated urea deposit with a deposit upper threshold limit, and initiating an SCR regeneration event when the mass of the accumulated urea deposit is greater than the deposit upper threshold limit. The method further includes determining an amount of NH3 passing through the SCR catalyst downstream of the urea deposit, comparing the amount of NH3 passing through the SCR catalyst with an NH3 regeneration threshold limit, and terminating the SCR regeneration event when the level of NH3 passing through the SCR catalyst is less than the SCR NH3 regeneration threshold.

Abstract: The present invention relates to a non-plowing method for establishing vegetation on at least partially denuded land comprising the steps of: (a) laying out a continuous layer of nutrient matrix directly on said at least partially denuded land, said layer of nutrient matrix containing water and nutrient contents necessary for the growth of plants; (b) sowing plant seeds on the top surface of said at least partially denuded land before said layer of nutrient matrix is laid out, or sowing plant seeds into said layer of nutrient matrix after it is laid out, or mixing plant seeds with the constituents of said layer of nutrient matrix and laying out together with said layer of nutrient matrix; (c) establishing an artificial vegetable cover on said at least partially denuded land by supplying said plant seeds water and nutrient contents in said layer of nutrient matrix to sustain their growth.

Abstract: The present invention relates to a non-plowing method for establishing vegetation on at least partially denuded land comprising the steps of: (a) laying out a continuous layer of nutrient matrix directly on said at least partially denuded land, said layer of nutrient matrix containing water and nutrient contents necessary for the growth of plants; (b) sowing plant seeds on the top surface of said at least partially denuded land before said layer of nutrient matrix is laid out, or sowing plant seeds into said layer of nutrient matrix after it is laid out, or mixing plant seeds with the constituents of said layer of nutrient matrix and laying out together with said layer of nutrient matrix; (c) establishing an artificial vegetable cover on said at least partially denuded land by supplying said plant seeds water and nutrient contents in said layer of nutrient matrix to sustain their growth.