Abstract: A long-chain compound, a preparation method therefor and the use thereof are disclosed. The structure of said compound is represented by formula (I). The definition of each substituent in the formula is as set out in the description and claims. The compound can directly inhibit ACLY, inhibit lipid synthesis in primary hepatocytes, inhibit lipid de novo synthesis and histone acetylation in various cancer cells such as H358, and inhibit cancer cell proliferation. The compound may be used to prepare drugs that treat metabolic diseases such as hyperlipidemia and atherosclerosis or various cancers such as lung cancer, pancreatic cancer, breast cancer, ovarian cancer, liver cancer, intestinal cancer, brain cancer, and acute myeloid leukemia.

Abstract: The present application discloses a box device. A hinge assembly of the box device is provided with a first sliding rail and a second sliding rail. The first sliding rail linearly extends, and the second sliding rail extends along an ellipse. When a door body blocks an opening, the first sliding rail is obliquely disposed opposite to the plane in which the opening is located, and the part of the second sliding rail away from a box body is close to a pivoting side relative to the first sliding rail, and the door body moves towards a target side of the box during a process from blocking the opening by the door body to opening the door body relative to the box body, to reduce the extent to which the door body exceeds an outer sidewall of the box body.

Abstract: A gas leak detection device and a detecting method are provided. The gas leak detection device includes a remote temperature sensor and a processor. The remote temperature sensors detect an area-to-be-monitored to obtain a plurality of thermal images. Each pixel position in the thermal images includes a corresponding temperature value. The processor obtains the thermal images from the remote temperature sensor, calculates a detected temperature value of each environmental block according to each of a plurality of environmental blocks in the thermal images, calculates a temperature judgment threshold based on the detected temperature value of each environmental block in a detection time period, determines whether a temperature of at least one region-of-interest is abnormal based on the temperature judgment threshold, and performs a warning operation when the temperature of the at least one region-of-interest is abnormal.

Abstract: A method of microfabrication includes forming a sacrificial layer over a film. A resist layer is formed over the sacrificial layer. The resist layer includes an extreme ultraviolet (EUV) resist. A pattern is formed in the resist layer by an EUV exposure and a wet etch followed by rinsing and drying, resulting in uncovered portions of the sacrificial layer. The uncovered portions of the sacrificial layer are treated. The pattern is transferred from the resist layer to the film by performing an etch process.

Abstract: A display module is provided. The display module includes a light modulation layer, and the light modulation layer is located between a color film layer and a display substrate. The light modulation layer includes a plurality of modulation portions, and a modulation portion is correspondingly disposed between a light-emitting portion and a color film portion. The modulation portion includes a modulation structure and a transmission structure. The color film portion includes a first region and a second region. An orthogonal projection of the transmission structure on the corresponding color film portion is located within the first region. The second region is adjacent to another color film portion of a different color, and an orthogonal projection of the modulation structure on the corresponding color film portion is located in the second region. The modulation structure is used to converge exit light of the corresponding light-emitting portion.

Abstract: Disclosed herein is a blade for a turbine comprising a blade cover; a blade body; and a layer of adhesive disposed between the blade cover and the blade body; where the layer of adhesive comprises a first adhesive region and a second adhesive region; where the first adhesive region comprises an adhesive that is chemically different from an adhesive used in the second adhesive region.

Abstract: An electric treadmill includes an endless belt, a motor and a motor driving circuit. The motor driving circuit is operable to control electric current flow from a positive electrode through the motor to a negative electrode to drive the motor. The motor driving circuit has a power resistor and a switch element connected in series between the positive electrode and the negative electrode. When the motor driving circuit receives power from an external power source, the switch element automatically switches to an open state so that the power resistor is inactive. When the motor driving circuit does not receive power from the external power source, the switch element automatically switches to a closed state, and the power resistor becomes a load for consuming power generated by the motor when the endless belt is driven by an external force, such that the motor operates to resist rotation of the endless belt.

Abstract: A filter is provided. The filter includes: a filter cartridge, comprising a side wall and an upper end; a cartridge cover on the upper end of the filter cartridge, wherein the cartridge cover and the filter cartridge together define a first chamber. The filter further includes a filter chamber in the first chamber, a fiber filter material in the filter chamber, a water intake channel disposed on the filter cartridge or on the cartridge cover and in fluid communication with the filter chamber, and a water discharge channel in fluid communication with the filter chamber. The filter may be a water filter. An above-ground pool is also provided including the filter.

Abstract: Soluble TREML1 is involved in many inflammatory diseases and plays an important role in immune suppression. Soluble TREML1 can bind the l-domain of CD11b and induce an immune suppressive phenotype. Thus, soluble TREML1 may be a good target for treating inflammatory diseases. The present invention relates to antibodies that can reduce soluble TREML1 binding to CD11b+ immune cells and their uses for reversing TREML14 induced immune suppression. Anti-TREML1 antibodies provide a novel and potential therapy for these disease conditions such as cancer.

Abstract: In a system, apparatus, method, and non-transitory computer readable medium for implementing SRv6 multicasting for network assisted publish-subscribe systems, a source host device may be caused to, obtain multicast scheduling information from a software defined network (SDN) controller, the multicast scheduling information including information related to a plurality of multicast trees associated with a network, each multicast tree of the plurality of multicast trees including at least one network node, and transmit a plurality of multi-stream multicast transmissions associated with a source multicast stream transmission to a plurality of destination host devices using a multicast group session tree based on the multicast scheduling information, the multicast group session tree associated with a desired multicast group, the multicast group including the source host device and the plurality of destination host devices.

Abstract: A handheld tool that includes a plurality of mechanisms attached thereto. The mechanisms are configured to secure and/or store an application tool when not in use. Such a feature allows for both convenient storage as well as quick and easy access to the application tool as desired.

Abstract: An additive for 193 nm dry photoresist and a preparation method for and application of the additive. The structure of the additive is as shown in formula I, the weight-average molecular weight is 1000-3000, and the ratio of the weight-average molecular weight to the number-average molecular weight is 1-5. By using the additive, photoresist can form a photoresist film micropattern having excellent sensitivity and high resolution.

Abstract: A method and device for providing payload length indication in IEEE 802.11 wireless communications are disclosed. The last OFDM symbol of a transmission is divided into multiple symbol segments and a number of medium access control layer (MAC) and physical layer (PHY) symbol segments are then allocated. The allocated number of MAC symbol segments is indicated using a field in the SIGNAL field or MAC frame body. Mapping between MAC and PHY symbol segments is provided as is additional puncturing for OFDM symbol usage.

Abstract: Provided in the present invention is an anti-CD39 antibody, an antigen-binding fragment thereof, and pharmaceutical use thereof, and also provided are a chimeric antibody and a humanized antibody comprising CDR regions of the antibody, a pharmaceutical composition comprising the anti-CD39 antibody and the antigen-binding fragment thereof, and use of the antibody in preparing a medicament for treating diseases or disorders. The antibody of the present invention can specifically bind to CD39 and shows good effect in inhibiting tumor growth and good safety.

Abstract: Disclosed herein is related to a method for extending lifespan and/or delaying aging in a subject; the method comprises administering to the subject with an effective amount of (24S)-3?-hydroxy-5?-stigmastan-6-one, wherein the delaying aging comprises increasing vitality, muscle strength or motor coordination, insulin sensitivity, or basal metabolic rate; and/or reducing muscle weakness, loss of balance, hair graying, kyphosis, or hyperglycemia. Also encompassed in the present disclosure are methods for promoting weight loss or treating type 2 diabetes mellitus in a subject, in which the methods comprise administering to the subject an effective amount of (24S)-3?-hydroxy-5?-stigmastan-6-one.

Abstract: The present disclosure provides new anti-CD3 antibodies, including humanized ones, and their antigen-binding fragments. These antibodies can bind to both human and cynomolgus CD3 at high affinity, and their single chain fragments (scFv) can be readily incorporated into multispecific antibodies to effectively activate T cell in the presence of tumor cells. Further, even though a relatively small number, these antibodies have anti-CD3 activities of a broad range, which are accordingly categorized into nine different grades. As further demonstrated, these anti-CD3 antibodies and fragments can be suitably used in bi- or tri-specific antibodies to achieve optimized activities and safety margins.

Abstract: Provided are low glycosylated kallikrein I with no or a small amount of glycosylation at the NFS sequence and polyethylene glycol modified product and pharmaceutical applications. KLK1 with lower glycosylation at NFS is more active than KLK1 with higher glycosylation at NFS. A recombinant KLK1 mutant without N-glycosylation at the NFS sequence is also provided, containing only two N-glycosylation sites at NMS and NHT. Glycosylation of the recombinant KLK1 mutant is relatively more consistent, the molecular weight of the product is relatively more homogeneous, the yield is higher, the purification process is simpler, and the biological activity is higher, and the quality is more controllable.

Abstract: An easily-assembled swing-type tricycle, comprises a frame assembly, a wheel frame (4) arranged on the frame assembly, a transmission chamber arranged in the frame assembly and a transmission mechanism arranged in the transmission chamber; The frame assembly comprises a front frame (1), a swinging mechanism (3) and a gear box (2), the front frame (1) is connected to the gear box (2) through the swinging mechanism (3), and the gear box (2) is connected to the wheel frame (4). The transmission mechanism is arranged in the transmission chamber in the frame assembly, so that the transmission mechanism does not need to be mounted outside the frame, and the product is more compact in structure, the transmission mechanism can be pre-assembled in the transmission chamber before the product is packed and transported, reducing the assembly procedure by the consumer.

Abstract: Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.

Abstract: The disclosure provides a communication system between dies and a repairing method for lanes between dies. The communication system includes a transmitting device disposed on a first die and a receiving device disposed on a second die. During the transmission process in which the transmitting device transmits a data unit stream to the receiving device through a native lane, after the native lane is determined to be a degraded lane, the transmitting device transmits a synchronization flag to the receiving device through a redundant lane to notify a repair time point. During the uninterrupted transmission process of the data unit stream, the transmitting device uses the redundant lane instead of the degraded lane based on the repair time point, and the receiving device uses the redundant lane instead of the degraded lane based on the repair time point notified by the synchronization flag.