Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: The present invention discloses an isolated antibody that specifically binds to TL1A, comprising a heavy chain variable region (TL1A-VH) and a light chain variable region (TL1A-VL), comprising the CDR-H1, CDR-H2, and CDR-H3 sequences of a TL1A-VH sequence selected from the group consisting of SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 47, SEQ ID NO: 49, SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 57, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 78, SEQ ID NO: 80, SEQ ID NO: 89, SEQ ID NO: 93, SEQ ID NO: 95, SEQ ID NO: 97, SEQ ID NO: 99, SEQ ID NO: 101, SEQ ID NO: 103, SEQ ID NO: 105, SEQ ID NO: 110, SEQ ID NO: 120; and the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 18.

Abstract: Provided are a suspension of a triazole antifungal drug for an atomizer, and a preparation method therefor. The pH of the suspension is 3-8. The suspension comprises a triazole antifungal drug, a surfactant, an osmotic pressure regulator, a metal complexing agent, a pH regulator and water, wherein the triazole antifungal drug has a D50 diameter of 1-10 µm, and accounts for 0.025%-1% of the total mass of the suspension, and the mass ratio of the triazole antifungal drug to the surfactant is 1:1-50:1.

Abstract: The present disclosure provides a method for extracting lithium using a resin adsorbent to pretreat low-grade deep brine, which relates to the technical field of lithium extraction from brine. In the present disclosure, resin adsorbent is used to perform adsorption pretreatment on the concentrated brine, which can adsorb organic impurities in the concentrated brine without adsorbing lithium ions, so that the concentration of lithium ions is almost unchanged compared with the feed material, with the subsequent manganese-based lithium adsorbent, the adsorption rate of lithium can be increased by 41%; At the same time, pretreating the concentrated brine using resin adsorbents has shorter steps, less materials, and does not produce a large amount of low-value product gypsum, which makes the lithium extraction process simpler and easier to operate, and reduces production costs.

Abstract: The present invention provides novel antibodies that specifically bind to CD3 and uses thereof. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

Abstract: An electrical connector includes an insulating housing, at least one transmission module mounted in the insulating housing, and a shell surrounding the insulating housing. The at least one transmission module includes a terminal assembly, a flexible printed circuit board and at least one pad. The terminal assembly is adhered to the flexible printed circuit board. The terminal assembly has at least one terminal which has a fastening portion. One end of the fastening portion is arched downward to form a bending portion. The flexible printed circuit board has a linking portion, and at least one conductive piece disposed to an inner surface of the linking portion. The fastening portion and the bending portion of the at least one terminal are mounted to the flexible printed circuit board. The at least one pad is disposed to the at least one conductive piece.

Abstract: A touchpad and a sending unit for the same are provided. The sensing unit has two electrode layers and a separation assembly. The separation assembly has multiple deformation rooms and multiple gap assemblies. The deformation rooms communicate with the gap assemblies. The gap assemblies communicate with the exterior environment. When the upper electrode layer is pressed and deforms in the deformation rooms, the air in the deformation rooms is discharged through the gap assemblies so that the air does not accumulate in the remaining unstressed spaces to avoid resistance and to maintain the normal operation of the force sensing function.

Abstract: A touchpad and a sending unit for the same are provided. The sensing unit has two electrode layers and a separation assembly. The separation assembly has multiple deformation rooms and multiple gap assemblies. The deformation rooms communicate with the gap assemblies. The gap assemblies communicate with the exterior environment. When the upper electrode layer is pressed and deforms in the deformation rooms, the air in the deformation rooms is discharged through the gap assemblies so that the air does not accumulate in the remaining unstressed spaces to avoid resistance and to maintain the normal operation of the force sensing function.

Abstract: An electrical connector includes an insulating housing, at least one transmission module mounted in the insulating housing, and a shell surrounding the insulating housing. The at least one transmission module includes a terminal assembly, a flexible printed circuit board and at least one pad. The terminal assembly is adhered to the flexible printed circuit board. The terminal assembly has at least one terminal which has a fastening portion. One end of the fastening portion is arched downward to form a bending portion. The flexible printed circuit board has a linking portion, and at least one conductive piece disposed to an inner surface of the linking portion. The fastening portion and the bending portion of the at least one terminal are mounted to the flexible printed circuit board. The at least one pad is disposed to the at least one conductive piece.

Abstract: The present invention relates to a pyrimidine compound, a chloride salt thereof, and a manufacturing and application of same. The chloride salt of the pyrimidine compound is presented by formula (II). The chloride salt has higher solubility, good stability, higher bioavailability, and very low hygroscopicity, and has excellent inhibition against a PIM kinase.

Abstract: The present invention relates to a pyrimidine compound, a chloride salt thereof, and a manufacturing and application of same. The chloride salt of the pyrimidine compound is presented by formula (II). The chloride salt has higher solubility, good stability, higher bioavailability, and very low hygroscopicity, and has excellent inhibition against a PIM kinase.

Abstract: The present invention provides novel antibodies that specifically bind to CD3 and uses thereof. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

Abstract: A socket connector includes an insulating housing, a sliding block, a resilient element, a detection terminal assembly assembled to a rear end of the insulating housing, a connection terminal assembly assembled to the rear end of the insulating housing, at least one ground element, and an outer shell surrounding the insulating housing. A top of the insulating housing has a restricting groove. A rear of the restricting groove extends rearward to form a sliding groove. At least one side surface of the insulating housing is recessed inward to form at least one ground groove. A rear of a bottom of connecting space extends downward and rearward to form a holding groove. The sliding block is mounted in the sliding groove. The at least one ground element is received in the at least one ground groove. The resilient element is assembled to a top of the insulating housing.

Abstract: The present invention relates to a pyrimidine compound or salt thereof in an application for manufacturing a pharmaceutical product for preventing and /or treating an FLT3-related disease or disorder. The pyrimidine compound has a chemical structure as represented by formula (I).

Abstract: Disclosed herein are anti-IL-13-R?2 antibodies and antibody drug conjugates and methods for preparing and using the same.

Abstract: A plug connector includes an insulating housing, and a terminal surrounding the insulating housing. The insulating housing has a fastening portion. Two opposite sides of a top of the fastening portion protrude upward and are arched outward to form two fastening pieces. A fastening slot is formed among a lateral wall, an inner wall and a bottom wall of the terminal. Two portions of a top surface of the lateral wall protrude upward to form two insertion portions. The fastening portion is fastened in the fastening slot. One of the two insertion portions is located between one side of one of the two fastening pieces and one side of the other fastening piece. The other insertion portion is located between the other side of the one of the two fastening pieces and the other side of the other fastening piece.

Abstract: A display device is provided. The display device includes a pixel-displaying region, including: at least two pixels including a plurality of sub-pixels; and a light-shielding layer including a matrix portion and an enlarged portion, wherein the enlarged portion is disposed at an intersection of two of the adjacent sub-pixels and is adjacent to the matrix portion; wherein the matrix portion defines the sub-pixels, and a total area of the sub-pixels is defined as a first area and a ratio of an area of the enlarged portion to the first area is about 1.5% to 6%.

Abstract: In certain embodiments, a method includes receiving, using one or more processors, a trigger expression. The method may include processing, using the one or more processors, the trigger expression, the trigger expression comprising a first one or more terms comprising a first one or more fields, to generate a reduced trigger expression. The reduced trigger expression includes a second one or more terms comprising a second one or more fields and being logically equivalent to the trigger expression. The method may include generating, using the one or more processors, a dynamic state machine by generating a first data structure comprising each of the second one or more fields, generating, based on the first data structure, an expanded trigger expression by adding one or more additional terms for possible state transitions, and generating, based on the expanded trigger expression, a second data structure.

Abstract: A display device is provided. The display device includes a pixel-displaying region, including: at least two pixels including a plurality of sub-pixels; and a light-shielding layer including a matrix portion and an enlarged portion, wherein the enlarged portion is disposed at an intersection of two of the adjacent sub-pixels and is adjacent to the matrix portion; wherein the matrix portion defines the sub-pixels, and a total area of the sub-pixels is defined as a first area and a ratio of an area of the enlarged portion to the first area is about 1.5% to 6%.

Abstract: A display device is provided. The display device includes a first substrate including a pixel-displaying region; a second substrate disposed opposite to the first substrate; a sealant disposed between the first substrate and the second substrate and disposed outside the pixel-displaying region; and a spacer wall disposed between the first substrate and the second substrate and disposed between the pixel-displaying region and the sealant, wherein a first side of the spacer wall is adjacent to the pixel-displaying region and a second side of the spacer wall is adjacent to the sealant, and a height of the first side is greater than a height of the second side.