Abstract: The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.

Abstract: A method of in situ point spread function (PSF) retrieval is disclosed which includes encoding 3D location of molecules into PSFs, receiving molecule-generated images containing PSFs, segmenting the images into sub-PSFs, initializing template PSFs from a pupil function, determining a maximum normalized cross correlation (NCC) coefficient (NCCmax) between the sub- and template PSFs, associating each of the sub-PSFs with a template PSF based on the NCCmax and storing the sub-PSFs in associated bins, aligning and averaging the binned sub-PSFs, applying a phase retrieval algorithm to the averaged sub-PSFs to update the pupil function, regenerating the template PSFs, repeating until a difference between a new and a prior generation pupil function is below a predetermined threshold, generating in situ PSFs from the last pupil function, and applying a maximum likelihood estimation algorithm based on the in situ PSFs and the sub-PSFs to thereby generate lateral and axial locations of molecules.

Abstract: Provided is a method for synthesizing a chiral amine compound. A transaminase is used to transaminate a ketone substrate under the action of an amino donor, to obtain the chiral amine compound; and the conserved amino acid sequence region of the transaminase at least includes a region 1 (MAGLWCVN) and a region 2 (YNTFFKT). With the transaminase with the specific conserved amino acid sequence region to synthesize a large sterically hindered chiral amine, the enzyme catalytic reaction volume is small, the synthesizing route is short, the product yield is high, a high-cost noble metal is not required for catalysis under the synthesizing conditions, three wastes are reduced, and the production cost is saved.

Abstract: The present disclosure provides a screen detection method, an apparatus and a device, a computer program and a readable medium, and belongs to the technical field of screens. The method includes: receiving a cylindrical lens detection instruction for a target screen, wherein the cylindrical lens detection instruction at least includes target viewpoints; acquiring browsing images shot from the target screen under the target viewpoints in response to the detection instruction, wherein the target screen is a screen of which the light emission side is provided with cylindrical lenses; using the browsing images as viewpoint images under the condition that the browsing images include target contents; and outputting detection parameters of the cylindrical lenses on the target screen based on image parameters of the viewpoint images.

Abstract: Disclosed are an automatic welding system and method for large structural parts based on hybrid robots and 3D vision. The system comprises a hybrid robot system composed of a mobile robot and an MDOF robot, a 3D vision system, and a welding system used for welding. The rough positioning technique based on a mobile platform and the accurate recognition and positioning technique based on high-accuracy 3D vision are combined, so the working range of the MDOF robot in the XYZ directions is expanded, and flexible welding of large structural parts is realized. The invention adopts 3D vision, thus having better error tolerance and lower requirements for the machining accuracy of workpieces, positioning accuracy of mobile robots and placement accuracy of the workpieces; and the cost is reduced, the flexibility is improved, the working range is expanded, labor is saved, production efficiency is improved, and welding quality is improved.

Abstract: A measurement system includes a camera and a processor. The camera is configured to capture a measurement card image of a measurement card, and the measurement card image includes a number of feature pattern images. The processor is electrically connected to the camera and configured for analyzing the feature pattern images to obtain a feature point coordinate of a feature point of each feature pattern image, and inputting the feature point coordinates into a conversion matrix to obtain a tip coordinate of a tip of the measurement card.

Abstract: Embodiments of the present disclosure provide a device for kitchen waste digestion, including: a first treatment container, provided with a feed pipe and an exhaust pipe at a top, and internally configured with a plurality of pole plate pairs, the pole plate pairs including two pole plates, one of the pole plates being connected to a positive pole of a power source and another being connected to a negative pole of the power source, and a plurality of sieve holes being provided in each of the pole plates; and a second treatment container, a top of the second treatment container connecting to a bottom of the first treatment container, a middle part being configured with a plurality of filler layers spaced apart in a vertical direction, and a bottom being configured with an iron-carbon filler; and a filler in the filler layers including calcium peroxide and magnetite particles.

Abstract: The present invention discloses a composition and use. The composition comprises hemp seed oil and algal oil with a mass ratio of (20˜60):(30˜70). After a large number of screening studies on concerted application, the present inventors found that the composition has synergistic effects, specifically, it has significant inhibitory effects on weight gain of animal model rats for hyperlipidemia, can significantly increase the hypolipidemic efficacy, and has an anti-oxidation effect. In addition, the composition of the present invention has efficacies of improving learning and memory abilities, improving constipation, and protecting the liver. Medicaments and functional food made from the composition of the present invention are simple in production process, stable in product quality, clear in functional factor, prominent in health care efficacy, low in administration dosage, safe in use, without toxic and side effects, and are suitable for consumption of the general population.

Abstract: The present invention provides a panorama image capturing device and a panorama image capturing module thereof. The panorama image capturing module includes a lens structure, an optical structure, a single image sensing chip, and a single image signal processor. The lens structure includes a first lens assembly for capturing a first predetermined image light source, and a second lens assembly for capturing a second predetermined image light source. The optical structure is disposed between the first lens assembly and the second lens assembly. The single image sensing chip has a first image sensing region for receiving the first predetermined image light source through the optical structure, and a second image sensing region for receiving the second predetermined image light source through the optical structure. The first and the second predetermined image light sources are processed by the single image signal processor for obtaining a panorama image.

Abstract: A traditional Chinese medicine composition for promotion of browning of white adipocytes, as well as a preparation method and use thereof are provided. The traditional Chinese medicine composition of the present invention is made of Fructus Hippophae, Piper nigrum and Radix Glycyrrhizae. A natural product for promotion of browning of white adipocytes is prepared by using traditional Chinese medicine components with medicine food homology, which makes up for a blank of products made of natural raw materials in this research field, and can play a role in prevention/treatment of obesity and metabolic diseases associated therewith based on safety.

Abstract: A traditional Chinese medicine composition for promotion of browning of white adipocytes, as well as a preparation method and use thereof are provided. The traditional Chinese medicine composition is made of Radix Astragali seu Hedysari, Piper nigrum and Radix Glycyrrhizae. A natural product for promotion of browning of white adipocytes is prepared by using traditional Chinese medicine components with medicine food homology, which makes up for a blank of products made of natural raw materials in this research field, and can play a role in prevention/treatment of obesity and metabolic diseases associated therewith based on safety.

Abstract: The present invention discloses a composition and use. The composition comprises hemp seed oil and algal oil with a mass ratio of (20˜60):(30˜70). After a large number of screening studies on concerted application, the present inventors found that the composition has synergistic effects, specifically, it has significant inhibitory effects on weight gain of animal model rats for hyperlipidemia, can significantly increase the hypolipidemic efficacy, and has an anti-oxidation effect. In addition, the composition of the present invention has efficacies of improving learning and memory abilities, improving constipation, and protecting the liver. Medicaments and functional food made from the composition of the present invention are simple in production process, stable in product quality, clear in functional factor, prominent in health care efficacy, low in administration dosage, safe in use, without toxic and side effects, and are suitable for consumption of the general population.

Abstract: Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.

Abstract: Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.

Abstract: Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.

Abstract: Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.

Abstract: Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.

Abstract: Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.

Abstract: A supporting structure applied in a display device is provided. The display device includes a casing and a display panel. The supporting structure comprises a fastening component and a sustaining component. The fastening component including a hook set is used for supporting the display panel. The sustaining component having a plurality of slot sets is disposed on the casing. The hook set separately presses against the slots for forming different distances between the display panel and the casing.

Abstract: A supporting device and a display device using the same are provided. The supporting device is used for supporting the display device. The supporting device includes a first component and a second component. The first component has at least a first through hole. The second component having at least a second through hole includes at least an elasticity unit. The elastic unit is disposed near the second through hole. When the first component is overlapped with the second component, the first through hole is communicated with the second through hole. An inserting unit is inserted in the first through hole and the second through hole. When the inserting unit is inserted into the first through hole and the second through hole, the elastic unit is expanded by the inserting unit to tightly connect to the first through hole for fixing the first component on the second component.