Patents by Inventor Fang-Rong Chang

Fang-Rong Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230389492
    Abstract: The present invention generally relates to a hydroponic culture medium and a hydroponic planting system, more particularly to a Houttuynia cordata hydroponic culture medium, a Houttuynia cordata hydroponic planting system, Houttuynia cordata extracts, a method, and applications thereof.
    Type: Application
    Filed: March 14, 2023
    Publication date: December 7, 2023
    Inventors: FANG-RONG CHANG, WEI-HUNG WU, YI-HONG TSAI, CHUNG-HSIEN CHEN, YEN-CHI LOO, HSUEH-ER CHEN, YEN-CHANG CHEN, HUI-PING HSIEH, CHEN HSIEH
  • Patent number: 11771729
    Abstract: The present invention relates to a maca extract and uses thereof. The part of the maca extract extracted with polar solvent has anti-thrombotic activity, the part of the maca extract extracted with medium and low polarity solvents has anti-neutrophilic inflammatory and anti-allergic activities, the part of the maca extract extracted with low polarity solvent has anti-neutrophilic inflammatory activity and has pro-angiogenic activity.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: October 3, 2023
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Fang-Rong Chang, Chin-Chung Wu, Bing-Hung Chen, Tsong-Long Hwang, Shih-Wei Wang, Kartiko Arif Purnomo, Yi-Hong Tsai
  • Publication number: 20230131367
    Abstract: A use of extracts of roselle seeds for preparing a composition of antioxidant, anti-inflammation, anti-UVB, anti-allergy, whitening, moisturizing, and anti-wrinkle, wherein the extracts of the roselle seeds comprise lauric, palmitic, linoleic, oleic, or stearic acids; and a method for preparing the extracts of the roselle seeds comprises steps of: steeping of: extracting a weight ratio of the 12:1 to 20:1 roselle seeds and an ethanol solution with a concentration of 75 to 95%; and steeping the roselle seeds in the ethanol solution to obtain a suspension; and extraction of: the suspension being engaged in an extraction of a continuous and rapid oscillation with an ultrasonic energy with a total energy of 200 to 500W, wherein 1 to 3 hours of the oscillation is one cycle, and a total number of 3 to 5 cycles is lasted, in order to obtain roselle seed crude extracts.
    Type: Application
    Filed: October 24, 2022
    Publication date: April 27, 2023
    Inventors: Hui-Ping HSIEH, Chen HSIEH, Fang-Rong CHANG, Chia-Hua LIANG, Yen-Chang CHEN, Yi-Hong TSAI
  • Publication number: 20220387536
    Abstract: The present invention relates to a maca extract and uses thereof. The part of the maca extract extracted with polar solvent has anti-thrombotic activity, the part of the maca extract extracted with medium and low polarity solvents has anti-neutrophilic inflammatory and anti-allergic activities, the part of the maca extract extracted with low polarity solvent has anti-neutrophilic inflammatory activity and has pro-angiogenic activity.
    Type: Application
    Filed: May 31, 2022
    Publication date: December 8, 2022
    Inventors: FANG-RONG CHANG, CHIN-CHUNG WU, BING-HUNG CHEN, TSONG-LONG HWANG, SHIH-WEI WANG, KARTIKO ARIF PURNOMO, YI-HONG TSAI
  • Patent number: 11413267
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition has the capacity to treating or preventing a virus infection in a subject.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: August 16, 2022
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Chun Wang, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung Wu
  • Patent number: 10668122
    Abstract: The Toona sinensis extract of the present invention is prepared using supercritical fluid technique, wherein the method includes steps of: (a) drying the leaves of T. sinensis; (b) pulverizing the leaves as particles; and (c) extracting the particles with supercritical carbon dioxide to obtain the T. sinensis extract. This supercritical T. sinensis extract not only can decrease blood sugar level, but also promotes lipid degradation, inhibits the formation of huge lipid droplet and improves the metabolic symptoms. Accordingly, the T. sinensis extract further is able to be prepared as food supplement and pharmaceuticals.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: June 2, 2020
    Assignees: METAL INDUSTRIES RESEARCH & DEVELOPMENT CENTRE, KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Pei-Jung Lien, Chuan-Chia Sun, Tzu-Chen Kuo, Sheng-Chung Yang, Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Yi-Hong Tsai, Ying-Chi Du
  • Publication number: 20190255012
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition has the capacity to treating or preventing a virus infection in a subject.
    Type: Application
    Filed: December 21, 2018
    Publication date: August 22, 2019
    Applicant: Kaohsiung Medical University
    Inventors: Hui-Chun WANG, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung WU
  • Patent number: 10335445
    Abstract: The present invention relates to phorbol esters from the seeds of Aquilaria malaccensis by a series of chromatographic processes, and compositions containing these congeners for the treatment of allergic responses.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: July 2, 2019
    Assignee: WE-WIN APPLIED BIO-TECH CO., LTD.
    Inventors: Fang-Rong Chang, Bing-Hung Chen, Hsue-Yin Hsu, Yang-Chang Wu, Chen Hsieh, Hui-Ping Hsieh
  • Patent number: 10195176
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 5, 2019
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Chun Wang, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung Wu
  • Patent number: 10098853
    Abstract: Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4?-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR? inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR? ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1? (IL-1?) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 16, 2018
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Suh-Hang Juo, An-Shen Lin, Ying-Chi Du
  • Publication number: 20180161303
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Application
    Filed: January 30, 2018
    Publication date: June 14, 2018
    Applicant: Kaohsiung Medical University
    Inventors: Hui-Chun WANG, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung WU
  • Patent number: 9918962
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: March 20, 2018
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Chun Wang, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung Wu
  • Patent number: 9895329
    Abstract: Disclosed herein are novel formyl peptide receptor 1 (FPR1) antagonists and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders mediated by FPR1.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: February 20, 2018
    Inventors: Tsong-Long Hwang, Yung-Fong Tsai, Chun-Yu Chen, Liang-Mou Kuo, Yuan-Bin Cheng, Chih-Hsin Wang, Fang-Rong Chang, Yang-Chang Wu
  • Publication number: 20170266250
    Abstract: The present invention relates to phorbol esters from the seeds of Aquilaria malaccensis by a series of chromatographic processes, and compositions containing these congeners for the treatment or prevention of allergic responses. Furthermore, compositions are provided which comprise these phorbol esters in combination with at least one to assess the effects for preventing or treating allergies.
    Type: Application
    Filed: June 13, 2016
    Publication date: September 21, 2017
    Inventors: FANG-RONG CHANG, BING-HUNG CHEN, HSUE-YIN HSU, YANG-CHANG WU, CHEN HSIEH, HUI-PING HSIEH
  • Publication number: 20170252393
    Abstract: The Toona sinensis extract of the present invention is prepared using supercritical fluid technique, wherein the method includes steps of: (a) drying the leaves of T. sinensis; (b) pulverizing the leaves as particles; and (c) extracting the particles with supercritical carbon dioxide to obtain the T. sinensis extract. This supercritical T. sinensis extract not only can decrease blood sugar level, but also promotes lipid degradation, inhibits the formation of huge lipid droplet and improves the metabolic symptoms. Accordingly, the T. sinensis extract further is able to be prepared as food supplement and pharmaceuticals.
    Type: Application
    Filed: May 16, 2017
    Publication date: September 7, 2017
    Applicants: Metal Industries Research & Development Centre, Kaohsiung Medical University
    Inventors: Pei-Jung Lien, Chuan-Chia Sun, Tzu-Chen Kuo, Sheng-Chung Yang, Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Yi-Hung Tsai, Ying-Chi Du
  • Publication number: 20170226150
    Abstract: Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of Antrodia cinnamomea using HPLC and NMR, as well as the stereo structures and the amounts of the triterpenoid compositions. The cytotoxicity of triterpenoids is also revealed. Based on the aforementioned techniques, the presence and amounts of ergostane and lanostane in the drugs, healthcare food or other goods are able to be detected.
    Type: Application
    Filed: April 28, 2017
    Publication date: August 10, 2017
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: YANG-CHANG WU, FANG-RONG CHANG, MEI-CHIN LU, YING-CHI DU, TUNG-YING WU, YU-MING HSU
  • Publication number: 20160214918
    Abstract: A compound for treating a metabolic syndrome, comprising a structure of a 6Cs unit-3Cs unit-6Cs unit (C6-C3-C6) as shown in formula I, wherein: when R1 and R2 are both hydrogens, C3 has only single bonds; when R1 is an oxygen and R2 is one selected from a group consisting of an alkoxy, a benzyloxy and a halogen, C3 has only single bonds; when R1 is a deuterium and R2 is one selected from a group consisting of a hydrogen, an alkoxy, a benzyloxy and a halogen, C3 has one of a single bond and a double bond.
    Type: Application
    Filed: January 21, 2016
    Publication date: July 28, 2016
    Applicant: Kaohsiung Medical University
    Inventors: Fang-Rong Chang, Yang-Chang Wu, Tusty-Jiuan Hsieh, Chi-Ting Hsieh, Ferenc Fülöp, Sándor Balázs Ötvös
  • Publication number: 20160158190
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 9, 2016
    Applicant: Kaohsiung Medical University
    Inventors: Hui-Chun WANG, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung WU
  • Patent number: 9341605
    Abstract: Disclosed are a method for analyzing chemical profiles of components from a herbal medicine product. Components may include quinone (including rhein, sennoside A and/or aloe-emodin), stilbene containing resveratroloside, flavone including baicalin, and/or alkaloid including berberine and/or palmatine. The method includes steps of: (a) respectively chromatographing a methanol extract of product and standard(s) corresponding to the component(s) using HPLC; (b) comparing HPLC chromatogram of extract and standard(s); and (c) analyzing the chemical profiles of the product from the comparison results.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: May 17, 2016
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Fang-Rong Chang, Tung-Ying Wu, Yang-Chang Wu
  • Patent number: 9241962
    Abstract: A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract from A. camphorata induces the maturation of dendritic cells, enhances T cell proliferation and INF-? production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 26, 2016
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu