Patents by Inventor Fangdun JIANG

Fangdun JIANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED EGFR ANTIBODY WITH REDUCED AFFINITY, DRUG CONJUGATE, AND USE THEREOF
    Publication number: 20240009318
    Abstract: The present invention provides isolated antibodies that bind to the human EGFR protein, and ADCs of the antibodies. Pharmaceutical compositions including the antibodies and ADCs, and methods of treating cancer are also provided.
    Type: Application
    Filed: November 19, 2021
    Publication date: January 11, 2024
    Inventors: Bing XIA, Yuhong ZHOU, Ziping WEI, Lixia CAO, Fangdun JIANG
  • ANTI-CD276 ANTIBODY, ANTIBODY-DRUG CONJUGATE, AND USE THEREOF
    Publication number: 20230414781
    Abstract: Isolated anti-human B7-H3 antibody includes two heavy chains including a hinge region comprising an amino acid sequence that allows site-specific conjugation of cytotoxic drugs. Each heavy chain includes a human CH1 domain located upstream of and connected to the hinge region. The CH1 domain comprises a cysteine at the position of 142 according to the IMGT numbering scheme. ADCs containing the antibody conjugated with a cytotoxic drug are also provided. Pharmaceutical compositions including the antibody or the ADCs, and methods of treating cancer using the pharmaceutical compositions are also provided.
    Type: Application
    Filed: November 19, 2021
    Publication date: December 28, 2023
    Inventors: Bing XIA, Hao KONG, Lixia CAO, Fangdun JIANG, Yuhong ZHOU, Ziping WEI