Patents by Inventor Fangli MA

Fangli MA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11446342
    Abstract: The present disclosure relates to the field of microbial technology, and discloses a composite probiotics and the use thereof. The composite probiotics in the present disclosure is consisted of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631, Lactobacillus rhamnosus CCFM1044 and Lactobacillus casei CCFM711, whose effect of alleviating metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 alone or combination of the two, especially in aspects of lowering contents of serum low density lipoprotein, total cholesterol, and liver triglyceride and contents of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and IFN-?, and increasing contents of liver glutathione and superoxide dismutase, etc. The extent of decrease or increase is increased by 7.91% to 837.31% compared with the formulations of CCFM8630 or CCFM8631 alone or combination of the two probiotics. The combination of the four probiotics can achieve a significant synergistic effect.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: September 20, 2022
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Fangli Ma, Wei Chen, Gang Wang, Xiaofeng Zhu, Yuanyuan Wang, Junyong Xiao, Hao Zhang, Jianxin Zhao
  • Patent number: 11291697
    Abstract: The present disclosure relates to the field of microbial technology, and discloses a probiotic composition and use thereof. The probiotic composition in the present disclosure is consisted of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631 and Lactobacillus rhamnosus CCFM1044, whose effect of alleviating metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 alone or combination of the two, especially in aspects of lowering epididymal fat content, lowering fasting blood glucose level, lowering the area under sugar tolerance curve and lowering contents of serum low density lipoprotein and total cholesterol, improving liver antioxidant capacity and lowering serum IL-1? content, etc. The extent of decrease or increase is increased by 9.62% to 769.62% compared with formulations of a single probiotic or a combination of two probiotics. The combination of three probiotics achieves a significant synergistic effect.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: April 5, 2022
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Yuanyuan Wang, Wei Chen, Gang Wang, Xiaofeng Zhu, Fangli Ma, Junyong Xiao, Hao Zhang, Jianxin Zhao
  • Patent number: 11026988
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising Lycii fructus polysaccharide, Polygonati rhizoma polysaccharide, Caryophylli flos oil and Cinnamomi cortex oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: June 8, 2021
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Fangli Ma, Yuanyuan Wang, Minghua Hu, Renhuai Cong, Lingyun Xiao, Chung Wah Ma
  • Patent number: 10967016
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, MORINDAE OFFICINALIS RADIX polysaccharide, POLYGONATI RHIZOMA polysaccharide, ANGELICAE SINENSIS RADIX oil and MYRISTICAE SEMEN oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, enhances body immune function, restores normal immune surveillance function, decreases VEGF and TGF-?1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: April 6, 2021
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Yuanyuan Wang, Fangli Ma, Renhuai Cong, Minghua Hu, Chung Wah Ma
  • Patent number: 10968495
    Abstract: Provided is a strain CCFM8631 of Lactobacillus reuteri and use thereof. The strain CCFM8631 of Lactobacillus reuteri can significantly increase neurotransmitter 5-hydroxytryptamine level in peripheral blood, recover the hormone levels, for example testosterone and so on in peripheral blood of rat, normalize abnormal abundances of Blautia genus and Turicibacter genus, Oscillospira genus and Bifidobacterium genus in intestinal flora of rat affected by high-fat high-starch diet, show good tolerance to simulated gastrointestinal fluid and quickly colonize in intestinal, significantly improve pathological damages of tissues such as liver, duodenum and so on, and increase triglyceride and total cholesterol levels in serum and oral glucose tolerance of rat with metabolic syndrome caused by high-fat high-starch diet.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: April 6, 2021
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Fangli Ma, Wei Chen, Gang Wang, Guangsu Zhu, Yuanyuan Wang, Lingyun Xiao, Minghua Hu, Hao Zhang, Jianxin Zhao, Chung Wah Ma
  • Patent number: 10967017
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, GRIFOLA FRONDOSA polysaccharide, ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: April 6, 2021
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Minghua Hu, Fangli Ma, Yuanyuan Wang, Chung Wah Ma, Renhuai Cong, Lingyun Xiao
  • Patent number: 10960039
    Abstract: The present disclosure relates to the technical field of health care products and foodstuffs, in particular to a composition, a preparation method, and the use thereof in preparation of products for relieving thyroid nodules. The composition provided by the invention uses AtractylodisMacrocephalaeRhizoma and ChuanxiongRhizoma as raw materials, which show synergistic effect through rational combination. Experiments show that the composition provided by the invention can improve thyroid epithelial cell proliferation and reduce the thyroid index of thyroid nodules, and has the advantages of relieving thyroid nodules and protecting thyroid function. The invention has the advantages of simple combination, high safety, simple and easy handling and definite cure effect.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: March 30, 2021
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Lingyun Xiao, Renhuai Cong, Yuanyuan Wang, Fangli Ma, Chung Wah Ma
  • Publication number: 20200261519
    Abstract: The present disclosure relates to the field of microbial technology, and discloses a composite probiotics and the use thereof. The composite probiotics in the present disclosure is consisted of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631, Lactobacillus rhamnosus CCFM1044 and Lactobacillus casei CCFM711, whose effect of alleviating metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 alone or combination of the two, especially in aspects of lowering contents of serum low density lipoprotein, total cholesterol, and liver triglyceride and contents of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and IFN-?, and increasing contents of liver glutathione and superoxide dismutase, etc. The extent of decrease or increase is increased by 7.91% to 837.31% compared with the formulations of CCFM8630 or CCFM8631 alone or combination of the two probiotics. The combination of the four probiotics can achieve a significant synergistic effect.
    Type: Application
    Filed: July 24, 2019
    Publication date: August 20, 2020
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Fangli MA, Wei CHEN, Gang WANG, Xiaofeng ZHU, Yuanyuan WANG, Junyong XIAO, Hao ZHANG, Jianxin ZHAO
  • Publication number: 20200261515
    Abstract: The present disclosure relates to the field of microbial technology, and discloses a probiotic composition and use thereof. The probiotic composition in the present disclosure is consisted of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631 and Lactobacillus rhamnosus CCFM1044, whose effect of alleviating metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 alone or combination of the two, especially in aspects of lowering epididymal fat content, lowering fasting blood glucose level, lowering the area under sugar tolerance curve and lowering contents of serum low density lipoprotein and total cholesterol, improving liver antioxidant capacity and lowering serum IL-1? content, etc. The extent of decrease or increase is increased by 9.62% to 769.62% compared with formulations of a single probiotic or a combination of two probiotics. The combination of three probiotics achieves a significant synergistic effect.
    Type: Application
    Filed: July 24, 2019
    Publication date: August 20, 2020
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Yuanyuan WANG, Wei CHEN, Gang WANG, Xiaofeng ZHU, Fangli MA, Junyong XIAO, Hao ZHANG, Jianxin ZHAO
  • Patent number: 10744173
    Abstract: The present invention relates to the technical field of health-care product, and in particular relates to a traditional Chinese medicine composition having a function of regulating emotions, a process for preparing the same, and a product thereof. It was found that the composition of the present invention had effects of nourishing liver and kidney, regulating Yin and Yang, tonifying Qi and nourishing blood, regulating emotions, and protecting the function of autonomic nerve, and could improve pressure-induced anxiety and depression, inattention, poor spirit, dispirited, learning and memory capacity decline, etc. The invention has the advantages of specificity and remarkable effect, and it uses all natural medicinal and edible plants as raw materials, the combination of which is simple, safe and stable, and is suitable for long-term use.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: August 18, 2020
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Lingyun Xiao, Renhuai Cong, Minghua Hu, Yuanyuan Wang, Fangli Ma, Chung Wah Ma
  • Patent number: 10646537
    Abstract: The present disclosure relates to the field of health food technology, in particular to a traditional Chinese medicine composition, preparation method and use thereof. The traditional Chinese medicine composition is made from Coicis Semen, Hippophae Fructus, Citri Rubrum Exocarpium and Glycyrrhizae Radix et Rhizoma. The traditional Chinese medicine composition uses less species of Chinese herbs and has significant effect on reducing the circumference of waist and abdomen, reducing the weight of visceral fat and anti-inflammation by reasonable combination, and does not have side effects.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: May 12, 2020
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Renhuai Cong, Fangli Ma, Chung Wah Ma, Xiaoling Wang, Lingyun Xiao
  • Patent number: 10561167
    Abstract: The present invention provides a hypoglycemic composition and preparation method thereof, wherein the hypoglycemic composition comprises 1-99 parts by weight of anise oil and 1-99 parts by weight of onion oil. Compared with the prior art, the anise oil in the hypoglycemic composition of the present invention can inhibit aldose reductase and ?-glucosidase. The active ingredients of onion oil are sulfonylurea butyric acid and volatile substances containing sulfur including alliin, allylpropyl disulfide, S-allylcysteine sulfoxide (SACS) and so on, which prevent insulin from being destroyed by oxidation-reduction equilibrium. Anise oil and onion oil act synergistically to facilitate the hypoglycemic effect; moreover, anise oil and onion oil can be both used as medicine and food, and have no side effect.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: February 18, 2020
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Renhuai Cong, Fangli Ma, Chung Wah Ma
  • Patent number: 10420811
    Abstract: The present invention relates to cultivation of a selenium-rich Cyclocarya paliurus plant, extraction and use of active ingredients thereof, for overcoming disadvantages of high residue, poor absorption, and less environmental friendliness of fertilizers used in cultivation of a selenium-rich plant in the prior art, and overcoming disadvantages of low absorption rate and high adverse reaction rate in current extraction method and application of active ingredients in a selenium-rich plant. The present invention provides a method of cultivating a selenium-rich Cyclocarya paliurus plant, comprising use of a selenium-rich organic fertilizer during the cultivation, wherein the selenium-rich organic fertilizer comprises a selenium-rich yeast, a humic acid, an amino acid, a plant growth regulator and a foliar penetration enhancer.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: September 24, 2019
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Weihong Chen, Fangli Ma, Wei Liu, Meng L V, Chung Wah Ma
  • Publication number: 20190116829
    Abstract: The present disclosure relates to the field of food technology, specifically to a chocolate 3D printing material and a method for producing the same. In the chocolate 3D printing material provided by the present disclosure, the conventional chocolate sugar is replaced with maltitol and xylitol, which increases the fluidity of the chocolate paste while ensures the taste, and guarantees smooth discharge during 3D printing. The application of the traditional Chinese medicine extract may induce the formation of a stable crystal form V, promoting the mutual miscibility of chocolate multiphase system, preventing chocolate bloom, and extending the shell life of chocolate.
    Type: Application
    Filed: October 22, 2018
    Publication date: April 25, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Weihong CHEN, Junyong XIAO, Renhuai CONG, Fangli MA, Chung Wah MA
  • Publication number: 20190112675
    Abstract: Provided is a strain CCFM8631 of Lactobacillus reuteri and use thereof. The strain CCFM8631 of Lactobacillus reuteri can significantly increase neurotransmitter 5-hydroxytryptamine level in peripheral blood, recover the hormone levels, for example testosterone and so on in peripheral blood of rat, normalize abnormal abundances of Blautia genus and Turicibacter genus, Oscillospira genus and Bifidobacterium genus in intestinal flora of rat affected by high-fat high-starch diet, show good tolerance to simulated gastrointestinal fluid and quickly colonize in intestinal, significantly improve pathological damages of tissues such as liver, duodenum and so on, and increase triglyceride and total cholesterol levels in serum and oral glucose tolerance of rat with metabolic syndrome caused by high-fat high-starch diet.
    Type: Application
    Filed: August 23, 2018
    Publication date: April 18, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Fangli MA, Wei CHEN, Gang WANG, Guangsu ZHU, Yuanyuan WANG, Lingyun XIAO, Minghua HU, Hao ZHANG, Jianxin ZHAO, Chung Wah MA
  • Publication number: 20190112674
    Abstract: Provided is a strain CCFM8630 of Bifidobacterium adolescentis and use thereof. The strain CCFM8630 of Bifidobacterium adolescentis can significantly increase neurotransmitter 5-hydroxytryptamine level in peripheral blood of rat, recover the hormone levels, for example testosterone and so on in peripheral blood of rat, normalize abnormal abundances of Bifidobacterium genus, Blautia genus and Turicibacter genus in intestinal flora of rat affected by high-fat high-starch diet, show pretty good tolerance to simulated gastrointestinal fluid and quickly colonize in intestinal, significantly improve pathological damages of tissues such as liver, duodenum and so on, and increase triglyceride and total cholesterol levels in serum and oral glucose tolerance of rat with metabolic syndrome caused by high-fat high-starch diet.
    Type: Application
    Filed: August 22, 2018
    Publication date: April 18, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Yuanyuan WANG, Wei CHEN, Gang WANG, Guangsu ZHU, Fangli MA, Lingyun XIAO, Minghua HU, Hao ZHANG, Jianxin ZHAO, Chung Wah MA
  • Publication number: 20190070237
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, GRIFOLA FRONDOSA polysaccharide, ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Application
    Filed: August 9, 2018
    Publication date: March 7, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Minghua HU, Fangli MA, Yuanyuan WANG, Chung Wah MA, Renhuai CONG, Lingyun XIAO
  • Publication number: 20190070236
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, MORINDAE OFFICINALIS RADIX polysaccharide, POLYGONATI RHIZOMA polysaccharide, ANGELICAE SINENSIS RADIX oil and MYRISTICAE SEMEN oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, enhances body immune function, restores normal immune surveillance function, decreases VEGF and TGF-?1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Application
    Filed: August 8, 2018
    Publication date: March 7, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Yuanyuan WANG, Fangli MA, Renhuai CONG, Minghua HU, Chung Wah MA
  • Publication number: 20190070246
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising LYCII FRUCTUS polysaccharide, POLYGONATI RHIZOMA polysaccharide, CARYOPHYLLI FLOS oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Application
    Filed: August 8, 2018
    Publication date: March 7, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Fangli MA, Yuanyuan WANG, Minghua HU, Renhuai CONG, Lingyun XIAO, Chung Wah MA
  • Publication number: 20180369308
    Abstract: The present disclosure relates to the field of health care product and food technology, disclosing a Chinese herbal medicine composition having a function of relieving hypothyroidism, and preparation method and use thereof. The Chinese herbal medicine composition described in the present disclosure, in parts by weight, comprises: 10 to 100 parts of GINSENG RADIX ET RHIZOMA, 10 to 100 parts of LYCII FRUCTUS, and 6 to 60 parts of CINNAMOMI CORTEX. The Chinese herbal medicine composition described in the present disclosure adopts GINSENG RADIX ET RHIZOMA, LYCII FRUCTUS and CINNAMOMI CORTEX as starting materials, creates synergistic effects through rational combination. Experiments indicate that the Chinese herbal medicine composition described in the present disclosure can improve functions of the thyroid gland in rat hypothyroidism model, reduce serum VEGF level in the model, showing a function of relieving hypothyroidism and protecting the thyroid gland.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 27, 2018
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Lingyun XIAO, Renhuai CONG, Minghua HU, Yuanyuan WANG, Fangli MA, Chung Wah MA