Patents by Inventor Fangming Xu

Fangming Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ethoxy diphenyl ethane derivatives, preparation processes and uses thereof
    Patent number: 8686187
    Abstract: The invention discloses an ethoxydiphenylethane derivative and a synthetic method and uses thereof 4? position of phenylethane B aromatic ring is chemically modified by ethoxy and hydroxy at position 3? thereof is simultaneously modified to water soluble prodrug such as phosphate, and similarly, amino acid side chain is introduced to amino at position 3? to form amino acid amide water soluble prodrug having the structure shown as formula (I) the ethoxydiphenylethane derivative and the prodrug thereof include strong tubulin aggregation inhibiting ability and obvious target damage effect for tumor vessels, selectively cause dysfunction and structural damage of tumor vessels and induce apoptosis of vascular endothelial cells in order to play the role of killing tumor cells or inhibiting tumor metastasis in case that the tumor cells are free from the support of nutrition and oxygen.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: April 1, 2014
    Assignees: Shanghai Ecust Biomedicine Co., Ltd., Zhejiang Wild Wind Pharmaceutical Co. Ltd.
    Inventors: Fanhong Wu, Fanhua Xiao, Weiguo Zhou, Fangming Xu
  • Ethoxy Diphenyl Ethane Derivatives, Preparation Processes and Uses Thereof
    Publication number: 20120046492
    Abstract: The invention discloses an ethoxydiphenylethane derivative and a synthetic method and uses thereof 4? position of phenylethane B aromatic ring is chemically modified by ethoxy and hydroxy at position 3? thereof is simultaneously modified to water soluble prodrug such as phosphate, and similarly, amino acid side chain is introduced to amino at position 3? to form amino acid amide water soluble prodrug having the structure shown as formula (I) the ethoxydiphenylethane derivative and the prodrug thereof include strong tubulin aggregation inhibiting ability and obvious target damage effect for tumor vessels, selectively cause dysfunction and structural damage of tumor vessels and induce apoptosis of vascular endothelial cells in order to play the role of killing tumor cells or inhibiting tumor metastasis in case that the tumor cells are free from the support of nutrition and oxygen.
    Type: Application
    Filed: October 15, 2009
    Publication date: February 23, 2012
    Applicants: Zhejiang Wild Wind Pharmaceutical Co., Ltd., Shanghai Ecust Biomedicine Co.Ltd.
    Inventors: Fanhong Wu, Fanhua Xiao, Weiguo Zhou, Fangming Xu