Abstract: Compound of the 7a,8,9,10,11,1la-hexahydro-1H,7H-pyrano[2,3-c]xanthene type, method of preparation thereof, intermediates thereof and therapeutic applications thereof. The present invention relates to compounds of formula (I) in which R0 represents O or N—ORa, R1 is OH or protected OH, R2 R3 R4 represent, independently, a C1-C4 alkyl, R5 represents OH, a protected OH, —O—P(?O)(OH)2, a sugar, H, a halogen, —CF3, a C1-C4 alkyl, a C2-C4 alkenyl or a C2-C4 alkynyl, R6 represents H, OH, protected OH, —O—P(?O)(OH)2, or a sugar, R7 represents H, OH, protected OH, a halogen, a C1-C4 alkyl, a C2-C4 alkenyl, a C2-C4 alkynyl, a triazolyl, —O—Rb, N(Rc)(Rd), —C(?O)—N(Re)(Rf), —O—C(?O)—N(Rg)(Rh), and R8, R9, R10, and R11 are, independently, H, OH or protected OH. The present invention further relates to the method of preparation thereof, the intermediates thereof and the therapeutic applications thereof.

Abstract: The present invention relates to a process for preparing at least one schweinfurthin chosen from schweinfurthin G of formula (SW-G), schweinfurthin K of formula (SW-K) and schweinfurthin R of formula (SW-R), characterized in that it comprises a step of using mappain of formula (IV).