Abstract: Disclosed herein is a percutaneous catheter apparatus, comprising two nested needles; and an inner plunger; which is guided as a catheter to the tissue surrounding a hard implant to actuate and deploy a pair of sharp-tip needle-forceps that perform two concentric cuts, circularly spaced 90-degree apart from each other, to complete a 360 degree bore around the implant before squeezing to arrest and extract the implant, together with its surrounding tissue.

Abstract: Biosensing platform deployed in a catheter is described which permits long-term operation of biosensors monitoring glucose and other analytes subcutaneously or intraperitoneally (IP) to manage diabetes. A method for integrating a plurality of biosensors monitoring glucose and other analytes into a catheter platform. The catheter platform comprises of electrochemical sensors, sensor electronics, RF and optical communication devices, as well as pump control electronics to facilitate glucose management. Catheter mounted biosensor is shown with micro-dialysis provisions.

Abstract: A system and method is outlined for a wearable external device that communicates with a fully implantable miniaturized biosensor platform providing fast spatial detection and accurate assessment of the position and orientation of the implant within highly scattering tissue. The device and method provides spatial (x, y) position, depth (z) and rotational (?) state of the implantable biosensor platform. The spatial (x, y) position allows the ability to turn-on only one out of an entire array of LEDs that is in line-of-sight with the implant in order to conserve power. Similarly, the depth and rotational coordinates information is used to adjust the output light intensity of the selected light emitters to compensate the power delivered to the implant. The above attributes render the system compatible for usage during intense physical activity and for added user comfort through improved skin ventilation.

Abstract: A device and method are outlined for the manual or automated insertion and extraction of a miniaturized implantable biosensor underneath the skin. System comprises injection and extraction module that is in operable communication with a positioning and tracking module, microprocessor and data acquisition units. The positioning and tracking module utilizes light- or magnetic field-sensing arrays to provide spatial (x, y) position, depth (z) and rotational (?) state of the miniaturized implant. This is fed to the injection and extraction module that lines up a catheter. For extraction, the catheter is actively guided using sensing arrays to extract the biosensor. This system has also provisions to excise fibrosis tissue around the implant. This tool is operated in a manual or automatic mode to facilitate pain-free injection and extraction of a miniaturized biosensor with minimal trauma.

Abstract: This invention describes a hermetically sealed package which can be implanted in the body. The package comprise of stacked substrates where surface of one substrate hosts biosensors which are exposed to body fluids to monitor concentrations of substances selected from analytes, metabolites, and proteins, and body physiological parameters. The structure protects from body fluids devices that interface with the biosensor electrodes for electronic data processing, powering, and wireless communication. Biosensor electrodes are electrically connected to various electronic, optoelectronic, MEM devices using novel partial silicon vias (PSVs) that prevents leakage of body fluids. Various devices are located on different substrates which are stacked to save surface area. One of the substrate forms the cover plate which permits light for powering as well as sending receiving coded data including the analyte levels.

Abstract: Disclosed herein is an analyte sensing device capable of continuously monitoring metabolic levels of a plurality of analytes. The device comprises an external unit, which, for example, could be worn around the wrist like a wristwatch or could be incorporated into a cell phone or PDA device, and an implantable sensor platform that is suitable, for example, for implantation under the skin. The external device and the internal device are in wireless communication. In one embodiment, the external device and the internal device are operationally linked by a feedback system. In one embodiment, the internal device is encapsulated in a biocompatible coating capable of controlling the local tissue environment in order to prevent/minimize inflammation and fibrosis, promote neo-angiogenesis and wound healing and this facilitate device functionality.

Abstract: Disclosed herein is an analyte sensing device capable of continuously monitoring metabolic levels of a plurality of analytes. The device comprises an external unit, which, for example, could be worn around the wrist like a wristwatch or could be incorporated into a cell phone or PDA device, and an implantable sensor platform that is suitable, for example, for implantation under the skin. The external device and the internal device are in wireless communication. In one embodiment, the external device and the internal device are operationally linked by a feedback system. In one embodiment, the internal device is encapsulated in a biocompatible coating capable of controlling the local tissue environment in order to prevent/minimize inflammation and fibrosis, promote neo-angiogenesis and wound healing and this facilitate device functionality.

Abstract: This invention describes a hermetically sealed package which can be implanted in the body. The package comprise of stacked substrates where surface of one substrate hosts biosensors which are exposed to body fluids to monitor concentrations of substances selected from analytes, metabolites, and proteins, and body physiological parameters. The structure protects from body fluids devices that interface with the biosensor electrodes for electronic data processing, powering, and wireless communication. Biosensor electrodes are electrically connected to various electronic, optoelectronic, MEM devices using novel partial silicon vias (PSVs) that prevents leakage of body fluids. Various devices are located on different substrates which are stacked to save surface area. One of the substrate forms the cover plate which permits light for powering as well as sending receiving coded data including the analyte levels.

Abstract: An implantable, miniaturized platform and a method for fabricating the platform is provided, where the e platform includes a top cover plate and a bottom substrate, top cover plate including an epitaxial, Si-encased substrate and is configured to include monolithically grown devices and device contact pads, the Si-encased substrate cover plate including a gold perimeter fence deposited on its Si covered outer rim and wherein the bottom substrate is constructed of Si and includes a plurality of partial-Si-vias (PSVs), electronic integrated circuits, device pads, pad interconnects and a gold perimeter fence, wherein the device pads are aligned with a respective device contact pad on the top cover plate and includes gold bumps having a predetermined height, the top cover plate and the bottom substrate being flip-chip bonded to provide a perimeter seal and to ensure electrical connectivity between the plurality of internal devices and at least one external component.

Abstract: Disclosed herein is an analyte sensing device capable of continuously monitoring metabolic levels of a plurality of analytes. The device comprises an external unit, which, for example, could be worn around the wrist like a wristwatch or could be incorporated into a cell phone or PDA device, and an implantable sensor platform that is suitable, for example, for implantation under the skin. The external device and the internal device are in wireless communication. In one embodiment, the external device and the internal device are operationally linked by a feedback system. In one embodiment, the internal device is encapsulated in a biocompatible coating capable of controlling the local tissue environment in order to prevent/minimize inflammation and fibrosis, promote neo-angiogenesis and wound healing and this facilitate device functionality.

Abstract: The invention decribes an apparatus, Scanning Localized Evaporation Methodology (SLEM) for the close proximity deposition of thin films with high feature definition, high deposition rates, and significantly improved material economy. An array of fixed thin film heating elements, each capable of being individually energized, is mounted on a transport mechanism inside a vacuum chamber. The evaporable material is deposited on a heating element. The SLEM system loads the surface of heating elements, made of foils, with evaporable material. The loaded thin film heating element is transported to the substrate site for re-evaporation. The re-evaporation onto a substrate, which is maintained at the desired temperature, takes place through a mask. The mask, having patterned openings dictated by the structural requirements of the fabrication, may be heated to prevent clogging of the openings. The translation of the substrate past the evaporation site permits replication of the pattern over its entire surface.

Abstract: Scanning localized evaporation and deposition of an evaporant on a substrate utilizes a mask assembly comprised of a series of mask elements with openings thereon and spaced apart in a stack. The openings are aligned so as to direct the evaporant therethrough onto the substrate. The mask elements are heated and the stack may include a movable shutter element to block openings in adjacent mask elements. The evaporant streams are usually vertical but some may be oblique to the substrate, and they may be of different materials.

Abstract: This invention discloses novel device structures for full color flat panel displays utilizing pseudomorphically cladded quantum dot nanocrystals. Different colors are obtained by changing the core size and composition of the quantum dots while maintaining a nearly defect-free lattice at the core-cladding interface. Light emission from the quantum dot core is obtained either by injection or by avalanche electroluminescence. A nanotip emitter device is also presented. These generic devices can be addressed using a variety of conventional display drivers, including active and passive matrix configurations.

Abstract: Scanning localized evaporation and deposition of an evaporant on a substrate utilizes a mask assembly comprised of a series of mask elements with openings thereon and spaced apart in a stack.

Abstract: This invention describes an apparatus, Scanning Localized Evaporation Methodology (SLEM), for the close proximity deposition of thin films with high feature definition, high deposition rates, and significantly improved material economy. An array of heating elements, each capable of being individually energized, is mounted on a transport mechanism inside a vacuum chamber. The evaporable material is deposited on a heating element. The SLEM system loads the surface of heating elements, made of foils, with evaporable material. The loaded heating element is transported to the substrate site for re-evaporation. The re-evaporation onto a substrate, which is maintained at the desired temperature, takes place through a mask. The mask, having patterned openings dictated by the structural requirements of the fabrication, may be heated to prevent clogging of the openings. The translation of the substrate past the evaporation site permits replication of the pattern over its entire surface.

Abstract: A multiple quantum well birefringent spatial light modulator has a substrate, multiple quantum well layers thereon, contacts for applying a biasing electric field across the multiple quantum well layers; and a component for varying the biasing electric field to produce birefringence in the multiple quantum well layer enhanced by the Stark effect and thereby effecting modulation of light exiting therefrom. The electric field may be varied directly by varying the voltage applied across the contacts or by providing a photodetector in series with the multiple quantum well layers and using a writing beam impinging on a photodetector to vary the field.