Patents by Inventor Farhad Kosari
Farhad Kosari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11667970Abstract: Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. The imaging and/or quantifying may use a nucleic acid amplification technique.Type: GrantFiled: July 27, 2020Date of Patent: June 6, 2023Assignees: The Board of Trustees of the University of Illinois, Mayo Foundation for Medical Education and ResearchInventors: Rashid Bashir, Anurup Ganguli, Farhad Kosari
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Publication number: 20210010079Abstract: Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. The imaging and/or quantifying may use a nucleic acid amplification technique.Type: ApplicationFiled: July 27, 2020Publication date: January 14, 2021Applicants: The Board of Trustees of the University of Illinois, Mayo Foundation for Medical Education and ResearchInventors: Rashid BASHIR, Anurup GANGULI, Farhad KOSARI
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Patent number: 10724089Abstract: Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. The imaging and/or quantifying may use a nucleic acid amplification technique.Type: GrantFiled: October 6, 2017Date of Patent: July 28, 2020Assignees: The Board of Trustees of the University of Illinois, Mayo Foundation for Medical Education and ResearchInventors: Rashid Bashir, Anurup Ganguli, Farhad Kosari
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Patent number: 10494677Abstract: This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome.Type: GrantFiled: December 14, 2016Date of Patent: December 3, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventors: George Vasmatzis, John C. Cheville, Farhad Kosari, Cemile D. Savci-Heijink, Eric W. Klee, Jan Marie A. Willard, Lori S. Tillmans
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Patent number: 10203330Abstract: This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ASCL1 and RET expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided.Type: GrantFiled: March 10, 2017Date of Patent: February 12, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventors: Farhad Kosari, George Vasmatzis, Marie-Christine Aubry, Cristiane M. Ida
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Publication number: 20180119218Abstract: Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. The imaging and/or quantifying may use a nucleic acid amplification technique.Type: ApplicationFiled: October 6, 2017Publication date: May 3, 2018Inventors: Rashid BASHIR, Anurup GANGULI, Farhad Kosari
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Publication number: 20170285034Abstract: This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ASCL1 and RET expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided.Type: ApplicationFiled: March 10, 2017Publication date: October 5, 2017Applicant: Mayo Foundation for Medical Education and ResearchInventors: Farhad Kosari, George Vasmatzis, Marie-Christine Aubry, Cristiane M. Ida
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Publication number: 20170159131Abstract: This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome.Type: ApplicationFiled: December 14, 2016Publication date: June 8, 2017Inventors: George Vasmatzis, John C. Cheville, Farhad Kosari, Cemile D. Savci-Heijink, Eric W. Klee, Jan Marie A. Willard, Lori S. Tillmans
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Patent number: 9534249Abstract: This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome.Type: GrantFiled: November 30, 2012Date of Patent: January 3, 2017Assignee: Mayo Foundation for Medical Education and ResearchInventors: George Vasmatzis, John C. Cheville, Farhad Kosari, Cemile D. Savci-Heijink, Eric W. Klee, Jan Marie A. Willard, Lori S. Tillmans
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Publication number: 20160018399Abstract: This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ASCL1 and RET expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided.Type: ApplicationFiled: March 7, 2014Publication date: January 21, 2016Inventors: Farhad Kosari, George Vasmatzis, Marie-Christine Aubry, Cristiane M. Ida
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Publication number: 20150191789Abstract: This document provides methods and materials related to identifying prostate cancer in male mammals. For example, methods and materials for assessing a benign prostate sample (e.g., benign prostate tissue or cells) to determine whether or not a mammal has prostate cancer are provided.Type: ApplicationFiled: February 6, 2013Publication date: July 9, 2015Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Farhad Kosari, John C. Cheville, R. Jeffrey Karnes, George Vasmatzis
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Publication number: 20150024420Abstract: This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring prostate cancer in mammals are provided herein.Type: ApplicationFiled: October 7, 2014Publication date: January 22, 2015Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: George G. Klee, George Vasmatzis, Farhad Kosari, Eric W. Klee
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Patent number: 8871451Abstract: This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring prostate cancer in mammals are provided herein.Type: GrantFiled: September 7, 2012Date of Patent: October 28, 2014Assignee: Mayo Foundation for Medical Education and ResearchInventors: George G. Klee, George Vasmatzis, Farhad Kosari, Eric W. Klee
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Publication number: 20130004974Abstract: This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring prostate cancer in mammals are provided herein.Type: ApplicationFiled: September 7, 2012Publication date: January 3, 2013Inventors: George G. Klee, George Vasmatzis, Farhad Kosari, Eric W. Klee
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Patent number: 8338109Abstract: This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome.Type: GrantFiled: November 2, 2007Date of Patent: December 25, 2012Assignee: Mayo Foundation for Medical Education and ResearchInventors: George Vasmatzis, John C. Cheville, Farhad Kosari, Cemile Dilara Savci Heijink, Jan-Marie Willard Munz, Eric W. Klee, Lori Tillmans
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Patent number: 8273539Abstract: This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring prostate cancer in mammals are provided herein.Type: GrantFiled: September 25, 2007Date of Patent: September 25, 2012Assignee: Mayo Foundation for Medical Education and ResearchInventors: George G. Klee, George Vasmatzis, Farhad Kosari, Eric W. Klee
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Publication number: 20100130377Abstract: This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome.Type: ApplicationFiled: November 2, 2007Publication date: May 27, 2010Inventors: George Vasmatzis, John C. Cheville, Farhad Kosari, Cemile D. Savci-Heijink, Jan-Marie Willard Munz, Eric W. Klee, Lori Tillmans
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Publication number: 20100028881Abstract: This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring prostate cancer in mammals are provided herein.Type: ApplicationFiled: September 25, 2007Publication date: February 4, 2010Inventors: George G. Klee, George Vasmatzis, Farhad Kosari, Eric W. Klee
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Publication number: 20080119367Abstract: Methods and materials related to determining renal cell carcinoma aggressiveness are provided. For example, methods for determining whether a mammal with renal cell carcinoma will have a good or poor outcome are provided. In addition, nucleic acid arrays that can be used to determine whether a mammal with renal cell carcinoma will have a good or poor outcome are provided.Type: ApplicationFiled: December 16, 2005Publication date: May 22, 2008Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: George Vasmatzis, John C. Cheville, Farhad Kosari, Alexander S. Parker
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Publication number: 20030027178Abstract: The invention provides methods and materials for determining cancer diagnosis and prognosis based on examining the levels of CRISP-3 RNA and polypeptides in biological samples from a patient. The invention also provides kits that can be used to determine a cancer diagnosis or prognosis. The kits contain CRISP-3 antibodies, CRISP-3 nucleic acids, PSA antibodies, PSA nucleic acids, or any combinations of these.Type: ApplicationFiled: March 15, 2002Publication date: February 6, 2003Inventors: George Vasmatzis, Farhad Kosari, Yan Asmann, John Cheville