Patents by Inventor Farhad Parhami

Farhad Parhami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING FIBROTIC DISEASES
    Publication number: 20230381201
    Abstract: Described herein are methods and compositions for treating fibrotic diseases and disorders.
    Type: Application
    Filed: November 4, 2021
    Publication date: November 30, 2023
    Applicant: MAX BioPharma, Inc.
    Inventors: Farhad Parhami, Frank Stappenbeck, Feng Wang
  • METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS
    Publication number: 20230364111
    Abstract: Described herein are methods and compositions for treating viral infections.
    Type: Application
    Filed: October 7, 2021
    Publication date: November 16, 2023
    Applicants: MAX BioPharma, Inc., Japan as represented by Director-General of National Institute of Infectious Diseases
    Inventors: Farhad Parhami, Frank Stappenbeck, Koichi Watashi, Hirofumi Ohashi
  • OXYSTEROL COMPOUNDS AND USES THEREOF
    Publication number: 20230234982
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds for the modulation of Hedgehog signaling.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 27, 2023
    Inventors: Frank STAPPENBECK, Farhad PARHAMI, Feng WANG
  • Oxysterols and Hedgehog signaling
    Patent number: 10869875
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit Hedgehog signaling. Also described herein are methods for using such Hedgehog signaling inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of Hedgehog signaling.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: December 22, 2020
    Assignee: MAX BIOPHARMA, INC.
    Inventors: Frank Stappenbeck, Yi Chiao Fan, Feng Wang, Farhad Parhami
  • Bone-selective osteogenic oxysterol bisphosphonate analogs
    Patent number: 10421773
    Abstract: Oxysterol-bisphosphonate and oxysterol-alendronic acid compounds, compositions including them, and methods using them for the treatment of bone disorders.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: September 24, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Frank Stappenbeck, Brian T. Chamberlain
  • OXYSTEROLS AND HEDGEHOG SIGNALING
    Publication number: 20180311259
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit Hedgehog signaling. Also described herein are methods for using such Hedgehog signaling inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of Hedgehog signaling.
    Type: Application
    Filed: October 25, 2016
    Publication date: November 1, 2018
    Inventors: Frank STAPPENBECK, Yi Chiao FAN, Feng WANG, Farhad PARHAMI
  • Oxysterol analogue OXY133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
    Patent number: 9717742
    Abstract: This invention relates, e.g., to a synthetic compound, Oxy133, having the structure [Formula I] or a bioactive or pharmaceutical composition comprising Oxy133 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 1, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Michael E. Jung, Frank Stappenbeck
  • OXYSTEROLS AND HEDGEHOG SIGNALING
    Publication number: 20170189420
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit Hedgehog signaling. Also described herein are methods for using such Hedgehog signaling inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of Hedgehog signaling.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 6, 2017
    Inventors: Frank STAPPENBECK, Farhad PARHAMI
  • Bone-selective osteogenic oxysterol-bone targeting agents
    Patent number: 9683009
    Abstract: Compounds and compositions for the treatment of bone disorders are presented.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: June 20, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Farhad Parhami, Frank Stappenbeck, Michael E. Jung, William M. Pierce, Jr., Kevyn Merten, K. Grant Taylor
  • Oxysterol compounds and the hedgehog pathway
    Patent number: 9670244
    Abstract: This invention relates, for example, to synthetic oxysterols. Also described are methods for using the compounds, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: June 6, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Michael E. Jung, Jennifer R. Dwyer, Khanhlinh Nguyen
  • BONE-SELECTIVE OSTEOGENIC OXYSTEROL BISPHOSPHONATE ANALOGS
    Publication number: 20170022244
    Abstract: Oxysterol-bisphosphonate and oxysterol-alendronic acid compounds, compositions including them, and methods using them for the treatment of bone disorders.
    Type: Application
    Filed: May 1, 2015
    Publication date: January 26, 2017
    Inventors: Farhad Parhami, Frank Stappenbeck, Brian T. Chamberlain
  • Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
    Patent number: 9532994
    Abstract: The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and methods to treat patients to maintain bone mass, enhance bone formation and/or bone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents, such as bone morphogenic proteins, known to assist in bone formation. The invention further includes medicaments including oxysterols for the treatment of bone disorders and implants to facilitate bone repair.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: January 3, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Farhad Parhami
  • Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
    Patent number: 9526737
    Abstract: Synthetic oxysterols can be made and can be used for the treatment of bone disorders, obesity, cardiovascular disorders, and neurological disorders.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: December 27, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Michael E. Jung, Khanhlinh Nguyen, Dongwon Yoo, Woo-Kyun Kim
  • OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING
    Publication number: 20160206631
    Abstract: This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Application
    Filed: November 18, 2015
    Publication date: July 21, 2016
    Applicants: JOHNS HOPKINS UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad PARHAMI, Michael JUNG, Khanhlinh NGUYEN, Dongwon YOO, William MATSUI
  • BONE-SELECTIVE OSTEOGENIC OXYSTEROL-BONE TARGETING AGENTS
    Publication number: 20160159850
    Abstract: Compounds and compositions for the treatment of bone disorders are presented.
    Type: Application
    Filed: May 2, 2014
    Publication date: June 9, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad PARHAMI, Frank STAPPENBECK
  • NOVEL OXYSTEROL ANALOGUE, OXY149, INDUCES OSTEOGENESIS AND HEDGEHOG SIGNALING AND INHIBITS ADIPOGENESIS
    Publication number: 20150140059
    Abstract: This invention relates, e.g., to a synthetic compound, Oxy149, having the structure (Formula I) or a bioactive or pharmaceutical composition comprising Oxy149 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders. Oxy149 can be delivered either locally or systemically.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 21, 2015
    Inventors: Farhad Parhami, Michael Jung, Frank Stappenbeck, William Pierce, K. Grant Taylor, Kevyn E. Merten
  • OXYSTEROL ANALOGUE OXY133 INDUCES OSTEOGENESIS AND HEDGEHOG SIGNALING AND INHIBITS ADIPOGENESIS
    Publication number: 20150118277
    Abstract: This invention relates, e.g., to a synthetic compound, Oxy133, having the structure [Formula I] or a bioactive or pharmaceutical composition comprising Oxy133 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 30, 2015
    Inventors: Farhad Parhami, Michael E. Jung, Frank Stappenbeck
  • OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING
    Publication number: 20120309730
    Abstract: This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Application
    Filed: February 16, 2011
    Publication date: December 6, 2012
    Applicants: The Johns Hopkins University, The Regents of the University of California
    Inventors: Farhad Parhami, Michael Jung, Khanhlinh Nguyen, Dongwon Yoo, VIncente Meliton
  • Inhibition of PPAR gamma expression by specific osteogenic oxysterols
    Patent number: 8022052
    Abstract: This invention relates to methods for using agents to inhibit peroxisome proliferator activated receptor expression.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: September 20, 2011
    Assignee: The Regents of the University of California
    Inventors: Farhad Parhami, Woo-Kyun Kim, Michael E. Jung, Khanhlinh Nguyen
  • Agents and methods for enhancing bone formation
    Patent number: 7897588
    Abstract: The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and method to treat patients to maintain bone mass, enhance bone formation and/or bone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents known to assist in bone formation. The invention further includes medicaments including oxysterols for the treatment of bone disorders, local injections of oxysterols or cells (206) and implants (202) having agents or cells (203) to facilitate bone repair.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: March 1, 2011
    Assignee: The Regents of the University of California
    Inventor: Farhad Parhami