Abstract: Disclosed are systems, devices and methods for continuous and simultaneous monitoring of multiple analytes within interstitial fluid by an integrated system for a microneedle array sensor platform. In some aspects, the device includes a microneedle array sensor unit, an electronics unit and a housing structure. The electronics unit is in electrical communication with an array of electrode probe structures via an array of surface-mount, spring loaded pins, and the electronics unit includes a power source, a data processing unit, and a wireless transmitter. The housing structure is configured to encase, at least partially, the microneedle array sensor unit and the electronics unit, where the array of microneedles is exposed from a side of the housing structure. The device can be configured as a patch worn on skin of a patient user.