Abstract: A first set of embodiments relates to an apparatus comprising one or more processors configured to: access three-dimensional (3D) ultrasound imaging of an eye; generate at least one segmented ocular structure by segmenting at least one ocular structure represented in the 3D ultrasound imaging using at least one deep learning ocular structure segmentation model configured to generate a predicted segmentation volume of the at least one ocular structure based on at least one portion of the 3D ultrasound imaging; compute at least one clinical metric associated with the at least one segmented ocular structure based on the at least one segmented ocular structure; and display at least one of: the at least one segmented ocular structure, the at least one clinical metric, the 3D ultrasound imaging, or at least one portion of the 3D ultrasound imaging.

Abstract: A bypass device can be implanted into a body tissue to provide fluid channels through the body tissue. The bypass device includes an open tubular base, and a plurality of pronged features attached to the open tubular base, the pronged features being reconfigurable from a first position to a second position. In the first position the pronged features extend longitudinally along a plane of the open tubular base, and the pronged features are reconfigurable to the second position by flexing the pronged features relative to the tubular base, such that in the second position the pronged features are configured for insertion through the body tissue. The pronged features may be configured as opposing arrow-shaped tangs that are flexed to form tent structures that are insertable through the body tissue.

Abstract: A method of promoting wound healing and/or treating wounds in a subject in need thereof includes administering to cells proximate or about the periphery of the wound at least one agent that enhances C3aR and/or C5aR signaling of the cells.

Abstract: In one or more embodiments the present invention provides a three layer bimodal amphiphilic co-network (?-APCN) based drug delivery device and methods for its making and use. In various embodiments, the system is based on a three-layer scheme. A center layer is composed of a ?-APCN matrix containing a high drug loading and exhibiting high drug diffusivity and two outer layers which are also ?-APCN-based, contain no-drug and are instead loaded with a diffusional barrier such as vitamin E, which considerably slows drug diffusion through these outer layers. Both modeling and experimental data demonstrates that the combined effect of non-uniform distribution of drug loading and diffusion constants within the three-layer systems of various embodiments of the present invention is capable of maintaining a low local drug concentration at the polymer-fluid interface, thus achieving zero-order kinetics.

Abstract: A fluid communication device is configured to provide fluid flow between first and second chambers separated by tissue. The fluid communication device includes a member configured for insertion through and engagement of the tissue. The member includes a first opening near a first end of the member for fluidic communication with the first chamber and a second opening near a second end of the member for fluidic communication with the second chamber, the fluid member including a fluid passage that provides fluidic communication between the first and second chambers. The fluid communication device is configured to be positioned with the eye to provide fluid communication between an anterior chamber of the eye and Schlemm's canal.

Abstract: A fluid communication device is configured to provide fluid flow between first and second chambers separated by tissue. The fluid communication device includes a member configured for insertion through and engagement of the tissue. The member includes a first opening near a first end of the member for fluidic communication with the first chamber and a second opening near a second end of the member for fluidic communication with the second chamber, the fluid member including a fluid passage that provides fluidic communication between the first and second chambers. The fluid communication device is configured to be positioned with the eye to provide fluid communication between an anterior chamber of the eye and Schlemm's canal.