Patents by Inventor Fateme Sima Sariaslani

Fateme Sima Sariaslani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immobilized TAL biocatalyst for production of para-hydroxycinnamic acid
    Patent number: 8569036
    Abstract: TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: October 29, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Robert Dicosimo, Sharon L. Haynie, Lixuan Lisa Huang, Fateme Sima Sariaslani, Tina K. Van Dyk, Robert J. Trotman
  • Methods for the preparation of para-hydroxycinnamic acid and cinnamic acid at alkaline pH
    Patent number: 8003356
    Abstract: Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: August 23, 2011
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Arie Ben-Bassat, Fateme Sima Sariaslani, Lisa L. Huang, Ranjan Patnaik, David J. Lowe
  • Method for producing an L-tyrosine over-producing bacterial strain
    Patent number: 7700328
    Abstract: An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine production.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: April 20, 2010
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Anthony A. Gatenby, Ranjan Patnaik, Fateme Sima Sariaslani, Wonchul Suh, Tina K. Van Dyk
  • Method for producing an L-tyrosine over-producing bacterial strain
    Publication number: 20080118958
    Abstract: An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine production.
    Type: Application
    Filed: June 7, 2006
    Publication date: May 22, 2008
    Inventors: Anthony A. Gatenby, Ranjan Patnaik, Fateme Sima Sariaslani, Wonchul Suh, Tina K. Van Dyk
  • Immobilized TAL biocatalyst for production of para-hydroxycinnamic acid
    Publication number: 20080032371
    Abstract: TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
    Type: Application
    Filed: July 12, 2006
    Publication date: February 7, 2008
    Inventors: Robert Dicosimo, Sharon L. Haynie, Lixuan Lisa Huang, Fateme Sima Sariaslani, Robert J. Trotman, Tina K. Van Dyk
  • Methods for the production of tyrosine, cinnamic acid and para-hydroxycinnamic acid using recombinant microorganisms
    Patent number: 7303900
    Abstract: Genes encoding phenylalanine ammonia-lyase (PAL), tyrosine ammonia lyase (TAL) and phenylalanine hydroxylase (PAH) have been introduced into a host organism for the production of Para-hydroxycinnamic acid (PHCA). The introduction of these genes results in the redirection of carbon flow in the host, optimizing the flow of carbon from glucose to PHCA. The intermediates, tyrosine and cinnamic acid are also produced.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: December 4, 2007
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Wei Wei Qi, Fateme Sima Sariaslani, Xiao-Song Tang
  • Methods for increasing the resistance of a host cell to aromatic carboxylic acids
    Patent number: 7279321
    Abstract: The invention provides methods of increasing the production of aromatic carboxylic acids from a host cell via manipulation of the yhcRQP operon encoding a family of efflux proteins. Up-regulation of all or a sub-set of the genes in the yhcRQP were additionally found to enhance tolerance to aromatic carboxylic acids toxicity.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: October 9, 2007
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Fateme Sima Sariaslani, Tina K. Van Dyk
  • Microbial conversion of glucose to para-hydroxystyrene
    Patent number: 7229806
    Abstract: An in vivo method for the production of pHS via a recombinant host cell is disclosed. The host cell expresses at least one gene encoding a polypeptide having para-hydroxycinnamic acid decarboxylase activity in combination with either at least one gene encoding a polypeptide having tyrosine ammonia lyase activity or at least one gene encoding a polypeptide having phenylalanine ammonia lyase activity.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: June 12, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Arie Ben-Bassat, Wei Wei Qi, Fateme Sima Sariaslani, Xiao-Song Tang, Todd M. Vannelli
  • Methods for the production of tyrosine, cinnamic acid and para-hydroxycinnamic acid
    Patent number: 7105326
    Abstract: Genes encoding phenylalanine ammonia-lyase (PAL), tyrosine ammonia lyase (TAL) and phenylalanine hydroxylase (PAH) have been introduced into a host organism for the production of Para-hydroxycinnamic acid (PHCA). The introduction of these genes results in the redirection of carbon flow in the host, optimizing the flow of carbon from glucose to PHCA. The intermediates, tyrosine and cinnamic acid are also produced.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: September 12, 2006
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Wei Wei Qi, Fateme Sima Sariaslani, Xiao-Song Tang
  • DNA and amino acid sequences of a tyrosine-inducible tyrosine ammonia lyase enzyme from the yeast Trichosporon cutaneum
    Patent number: 6951751
    Abstract: A novel tyrosine-inducible tyrosine ammonia lyase enzyme was isolated from the yeast Trichosporon cutaneum. This enzyme has a higher activity for tyrosine than for phenylalanine and is useful for the production of para-hydroxycinnamic acid directly from tyrosine. The gene encoding this enzyme was sequenced using 3? and 5? RACE cloning of the TAL cDNA and the gene was expressed in the yeast Saccharomyces cerevisiae and in the bacterium Escherichia coli.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: October 4, 2005
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Sabine Breinig, Wei Wei Qi, Fateme Sima Sariaslani, Todd M. Vannelli, Zhixiong Xue
  • Pet family of efflux proteins
    Publication number: 20040147000
    Abstract: The invention provides methods of increasing the production of aromatic carboxylic acids from a host cell via manipulation of the yhcRQP operon encoding a family of efflux proteins. Up-regulation of all or a sub-set of the genes in the yhcRQP were additionally found to enhance tolerance to aromatic carboxylic acids toxicity.
    Type: Application
    Filed: January 16, 2004
    Publication date: July 29, 2004
    Inventors: Fateme Sima Sariaslani, Tina K. Van Dyk
  • DNA and amino acid sequences of a tyrosine-inducible tyrosine ammonia lyase enzyme from the yeast Trichosporon cutaneum
    Publication number: 20040023357
    Abstract: A novel tyrosine-inducible tyrosine ammonia lyase enzyme was isolated from the yeast Trichosporon cutaneum. This enzyme has a higher activity for tyrosine than for phenylalanine and is useful for the production of para-hydroxycinnamic acid directly from tyrosine. The gene encoding this enzyme was sequenced using 3′ and 5′ RACE cloning of the TAL cDNA and the gene was expressed in the yeast Saccharomyces cerevisiae and in the bacterium Escherichia coli.
    Type: Application
    Filed: May 16, 2003
    Publication date: February 5, 2004
    Inventors: Sabine Breinig, Wei Wei Qi, Fateme Sima Sariaslani, Todd M. Vannelli, Zhixiong Xue
  • Microbial conversion of glucose to para-hydroxystyrene
    Publication number: 20040018600
    Abstract: An in vivo method for the production of pHS via a recombinant host cell is disclosed. The host cell expresses at least one gene encoding a polypeptide having para-hydroxycinnamic acid decarboxylase activity in combination with either at least one gene encoding a polypeptide having tyrosine ammonia lyase activity or at least one gene encoding a polypeptide having phenylalanine ammonia lyase activity.
    Type: Application
    Filed: May 16, 2003
    Publication date: January 29, 2004
    Inventors: Arie Ben-Bassat, Wei Wei Qi, Fateme Sima Sariaslani, Xiao-Song Tang, Todd M. Vannelli
  • Methods for the production of tyrosine, cinnamic acid and para-hydroxycinnamic acid
    Publication number: 20030079255
    Abstract: Genes encoding phenylalanine ammonia-lyase (PAL), tyrosine ammonia lyase (TAL) and phenylalanine hydroxylase (PAH) have been introduced into a host organism for the production of Para-hydroxycinnamic acid (PHCA). The introduction of these genes results in the redirection of carbon flow in the host, optimizing the flow of carbon from glucose to PHCA. The intermediates, tyrosine and cinnamic acid are also produced.
    Type: Application
    Filed: May 3, 2002
    Publication date: April 24, 2003
    Inventors: Wei Wei Qi, Fateme Sima Sariaslani, Xiao-Song Tang