Abstract: The present invention relates to a method (100) of producing solid microneedles with a desired geometry, base width, height, height/base width ratio, tip angle and number of needles by means of photolithography and dry etching techniques.

Abstract: The present disclosure advantageously provides a heterogenous system, and a method for generating an artificial neural network (ANN) for a heterogenous system. The heterogenous system includes a plurality of processing units coupled to a memory configured to store an input volume. The plurality of processing units includes first and second processing units. The first processing unit includes a first processor and is configured to execute a first ANN, and the second processing unit includes a second processor and is configured to execute a second ANN. The first and second ANNs respectively include an input layer, at least one processor-optimized hidden layer and an output layer. The second ANN hidden layers are different than the first ANN hidden layers.

Abstract: Embodiments of the present disclosure relate to a magnetic bead platform for isolating sperm cells from biological samples. In some embodiments, such magnetic bead platforms integrate recognition reagents to its surface to bind target cells, such as sperm cells. Such embodiments provide the ability to at least one of rapidly isolate and quantitate sperm cells from biological samples as occur in sexual assault evidence, for example, thereby enhancing identification of suspects in these cases and contributing to the safety of society.

Abstract: The present disclosure advantageously provides a heterogenous system, and a method for generating an artificial neural network (ANN) for a heterogenous system. The heterogenous system includes a plurality of processing units coupled to a memory configured to store an input volume. The plurality of processing units includes first and second processing units. The first processing unit includes a first processor and is configured to execute a first ANN, and the second processing unit includes a second processor and is configured to execute a second ANN. The first and second ANNs respectively include an input layer, at least one processor-optimized hidden layer and an output layer. The second ANN hidden layers are different than the first ANN hidden layers.

Abstract: Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.

Abstract: Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.

Abstract: Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.

Abstract: A nanoplasmonic platform can be used for the detection and quantification of multiple HIV subtypes in whole blood with localized surface plasmon resonance. Among other things, this nanoplasmonic platform provides a viable way to detection and quantification of viral load at a point of care with significantly less cost, time, and laboratory resources than existing methods of detection. Although an example of HIV detection in whole blood is provided, the nanoplasmonic platform is adaptable to detect other pathogens and infectious agents or macromolecules.

Abstract: Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.

Abstract: Embodiments of the present disclosure relate to a platform for at least one of capturing, identifying and studying biological materials, and more particularly, to microfluidic channel platforms (for example) for detecting and/or identifying samples containing sperm cells, and isolating and analyzing captured sperm cells for DNA analysis (for example). In some embodiments, such microfluidic platforms integrate imaging technology. Such embodiments provide the ability to at least one of rapidly isolate and quantitate sperm cells from biological mixtures as occur in sexual assault evidence, for example, thereby enhancing identification of suspects in these cases and contributing to the safety of society.

Abstract: A nanoplasmonic platform can be used for the detection and quantification of multiple HIV subtypes in whole blood with localized surface plasmon resonance. Among other things, this nanoplasmonic platform provides a viable way to detection and quantification of viral load at a point of care with significantly less cost, time, and laboratory resources than existing methods of detection. Although an example of HIV detection in whole blood is provided, the nanoplasmonic platform is adaptable to detect other pathogens and infectious agents or macromolecules.