Patents by Inventor Fatih Ozsolak

Fatih Ozsolak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180311176
    Abstract: Aspects of the disclosure relate to particle formulations, e.g., nanoparticle formulations, methods of making particle formulations, and methods for delivery of oligonucleotides and/or synthetic RNA, e.g., for increasing gene expression in a targeted manner. In some embodiments, compositions and methods are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the disclosure described herein provide compositions and methods that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: October 26, 2016
    Publication date: November 1, 2018
    Applicant: Translate Bio MA, Inc.
    Inventors: Fatih Ozsolak, Balkrishen Bhat
  • Patent number: 10041074
    Abstract: Provided herein are oligonucleotides complementary to euchromatic regions of target genes that are useful for increasing expression of the target genes; related compositions and methods are also provided.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: August 7, 2018
    Assignee: Translate Bio MA, Inc.
    Inventor: Fatih Ozsolak
  • Publication number: 20180055869
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods are provided for increasing expression of a gene expressed in a liver cell. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: February 12, 2016
    Publication date: March 1, 2018
    Applicant: Translate Bio MA, Inc.
    Inventor: Fatih Ozsolak
  • Publication number: 20180030452
    Abstract: Aspects of the invention provide single stranded oligonucleotides for modulating expression of genes based on targeting of low abundance non-coding RNA transcripts. Further aspects provide compositions and kits comprising single stranded oligonucleotides for modulating expression of genes. Methods for modulating expression of genes using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for modulating expression of genes.
    Type: Application
    Filed: February 12, 2016
    Publication date: February 1, 2018
    Applicant: Translate Bio MA, Inc.
    Inventor: Fatih Ozsolak
  • Publication number: 20180028557
    Abstract: Provided herein are hybrid oligonucleotides comprising a region that promotes cleavage of a nucleic acid and a region that protects a nucleic acid from exonuclease activity. Such hybrid oligonucleotides are useful for modulating the expression of genes. Related compositions and methods are also provided. In some embodiments, methods are provided for treating a disease, such as by administering a hybrid oligonucleotide.
    Type: Application
    Filed: February 12, 2016
    Publication date: February 1, 2018
    Applicant: Translate Bio MA, Inc
    Inventor: Fatih Ozsolak
  • Publication number: 20170152511
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: April 30, 2015
    Publication date: June 1, 2017
    Applicant: RaNA Therapeutics, Inc.
    Inventor: FATIH OZSOLAK
  • Publication number: 20160201063
    Abstract: Provided herein are methods for increasing Frataxin (FXN) expression that involve targeting or expressing regulatory factors that modulate the epigenetic state of FXN genes. Also provided herein are methods for increasing FXN expression using inhibitors of a negative epigenetic regulator of FXN. Compositions and methods for treating Friedrich's ataxia are also provided.
    Type: Application
    Filed: August 15, 2014
    Publication date: July 14, 2016
    Applicant: RaNA Therapeutics, Inc.
    Inventor: Fatih Ozsolak
  • Publication number: 20160201064
    Abstract: Provided herein are compositions and methods for increasing Frataxin (FXN) expression. Compositions and methods for treating Friedrich's ataxia are also provided.
    Type: Application
    Filed: August 15, 2014
    Publication date: July 14, 2016
    Applicant: RaNA Therapeutics, Inc.
    Inventor: Fatih Ozsolak
  • Publication number: 20150307932
    Abstract: The invention generally relates to methods for analyzing cellular nucleic acid. Methods of the invention involve capturing RNA from a lysed cell onto a substrate, producing a cDNA/RNA duplex, removing the RNA from the cDNA/RNA duplex, priming the cDNA to produce a primer/cDNA duplex, exposing the primer/cDNA duplex to at least one detectably labeled nucleotide in the presence of a polymerase capable of catalyzing addition of the nucleotide to the primer/cDNA duplex, detecting incorporation of the nucleotide into the primer portion, and repeating the exposing and detecting steps at least once.
    Type: Application
    Filed: January 17, 2014
    Publication date: October 29, 2015
    Inventors: Fatih Ozsolak, Patrice M. Milos
  • Publication number: 20150247144
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: April 30, 2015
    Publication date: September 3, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: FATIH OZSOLAK
  • Publication number: 20150247145
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: April 30, 2015
    Publication date: September 3, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: FATIH OZSOLAK
  • Publication number: 20150232858
    Abstract: Provided herein are oligonucleotides complementary to euchromatic regions of target genes that are useful for increasing expression of the target genes; related compositions and methods are also provided.
    Type: Application
    Filed: April 30, 2015
    Publication date: August 20, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: Fatih Ozsolak
  • Publication number: 20150232846
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: April 30, 2015
    Publication date: August 20, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: FATIH OZSOLAK
  • Publication number: 20150232845
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: April 30, 2015
    Publication date: August 20, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: FATIH OZSOLAK
  • Publication number: 20150232847
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: April 30, 2015
    Publication date: August 20, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: FATIH OZSOLAK
  • Publication number: 20150232844
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: April 30, 2015
    Publication date: August 20, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: FATIH OZSOLAK
  • Publication number: 20150225722
    Abstract: Provided herein are oligonucleotides that are useful for modulating the heterochromatin state of genes; related compositions and methods are also provided. In some embodiments, methods are provided for treating a disease associated with heterochromatin formation, including diseases associated with repeat expansion within genes.
    Type: Application
    Filed: April 29, 2015
    Publication date: August 13, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: Fatih Ozsolak
  • Publication number: 20150225715
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: April 30, 2015
    Publication date: August 13, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventor: FATIH OZSOLAK
  • Publication number: 20150050738
    Abstract: Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation).
    Type: Application
    Filed: August 15, 2014
    Publication date: February 19, 2015
    Applicant: RaNA Therapeutics, Inc.
    Inventors: Fatih Ozsolak, Caroline Woo
  • Publication number: 20120028822
    Abstract: A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule analysis are also provided.
    Type: Application
    Filed: November 4, 2009
    Publication date: February 2, 2012
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Richard Joseph, James Dimeo, Mirna Jarosz, John F. Thompson, Jayson Bowers, Scott Chouinard, Philipp Kapranov, William J. Efcavitch, Christopher Hart, Fatih Ozsolak