Abstract: A device for occluding a patient's left atrial appendage (LAA) device includes a self-expanding closure disc and an anchor. The self-expanding closure disc has an atrial side, an appendage side, and a peripheral edge configured to engage tissue on both an atrial side and an appendage side of an opening between the left atrium and the left atrial appendage. The self-expanding anchor extends from the appendage side of the self-expanding closure disc, and an annular sealing skirt extends about at least a portion of the appendage side of the self-expanding closure disc. the annular sealing skirt is more compliant than the self-expanding closure disc to seal over the left appendage side of the opening after implantation of the device in the LAA.

Abstract: An endoluminal prosthesis includes a stent-graft and a temporary aortic valve, typically combined in an integrated assembly suitable for transfemoral or other endoluminal placement in a patient's ascending aorta, aortic root, and aortic valve. The stent-graft has a base end configured to be positioned into over the patient's aortic root and over the aortic annulus. The temporary aortic valve assembly is attached to the base end of the stent-graft and comprises a scaffold configured to be anchored in the patient's aortic annulus and valve leaflets configured to function temporarily after the endoluminal prosthesis has been implanted. At least one fenestration suitable for receiving a guidewire and/or a coronary stent graft is located near a junction between the base end of the stent graft and the temporary aortic valve, wherein said at least one fenestration is disposed on the endoluminal prosthesis to be aligned with one of the patient's coronary ostia after the endoluminal prosthesis has been implanted.