Patents by Inventor Federico Izzia
Federico Izzia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11313720Abstract: This invention relates to a system and method to improve the signal to noise ratio (SNR) of optical spectrometers that are limited by nonrandom or fixed pattern noise. A signal from a sample is collected using a short test exposure, a total observation time to maximize SNR is calculated, and the total observation time is achieved by averaging multiple exposures whose time is selected based on the time dependent noise structure of the detector. Moreover, with a priori knowledge of the time dependent noise structure of the spectrometer, this method is easily automatable and can maximize SNR for a spectrum of an unknown compound without any user input.Type: GrantFiled: January 22, 2016Date of Patent: April 26, 2022Assignee: Rigaku Raman Technologies, Inc.Inventors: Eric Roy, Jason Booth, Claude Robotham, Federico Izzia
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Publication number: 20160290864Abstract: This invention relates to a system and method to improve the signal to noise ratio (SNR) of optical spectrometers that are limited by nonrandom or fixed pattern noise. A signal from a sample is collected using a short test exposure, a total observation time to maximize SNR is calculated, and the total observation time is achieved by averaging multiple exposures whose time is selected based on the time dependent noise structure of the detector. Moreover, with a priori knowledge of the time dependent noise structure of the spectrometer, this method is easily automatable and can maximize SNR for a spectrum of an unknown compound without any user input.Type: ApplicationFiled: January 22, 2016Publication date: October 6, 2016Inventors: Eric Roy, Jason Booth, Claude Robotham, Federico Izzia
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Patent number: 9121755Abstract: A novel emission and transmission optical spectrometer is introduced herein, which is capable of optically interrogating solid or liquid samples of organic, inorganic or polymeric chemistry, for pharmaceutical research, forensic and liquid analyses, used for identification, purity check, and/or structural study of chemicals. The beneficial aspects of the system are a single sample compartment as confined within the walls of the spectrometer housing, a more compact accessory, and the capability of making both emission (e.g., Raman and Fluorescence) and Infrared (IR, NIR) transmission measurements at designed sample points.Type: GrantFiled: September 10, 2012Date of Patent: September 1, 2015Assignee: THERMO ELECTRON SCIENTIFIC INSTRUMENTS LLCInventors: Federico Izzia, Michael S. Bradley
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Patent number: 8547555Abstract: The present application is directed to a novel spectrometer configured with a built-in attenuated total reflectance (ATR) and accessory compartment. In particular, an arranged sample analysis compartment provided by the spectrometer performs attenuated total reflectance analysis of a sample and includes a crystal, a tip configured to press the sample against the crystal, and a detector configured to detect light after reflection within the crystal. As part of the configuration, an actuator moves an optical element between a first position wherein the optical element receives modulated light and reflects the modulated light toward the crystal and a second position wherein the optical element does not receive the modulated light so as to instead allow an additionally configured optical component to receive the modulated light.Type: GrantFiled: April 27, 2012Date of Patent: October 1, 2013Assignee: Thermo Electron Scientific Instruments LLCInventors: Michael S. Bradley, Federico Izzia, John M. Coffin
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Patent number: 8521491Abstract: A method and corresponding apparatus provide correction of chemical images collected with a germanium hemisphere ATR microscope. A model is developed for rays passing through a simulated germanium (Ge) hemisphere attenuated total reflection (ATR) microscope. The model determines a data set for rays reaching the detector plane. Movement of the hemisphere is simulated along a first axis between each data set determination. A calculated background spectrum is produced by multiplying the percentage of rays by a background spectrum to produce a calculated background spectrum. A real Ge hemisphere ATR microscope having parameters that substantially match those of the simulated Ge hemisphere microscope is then used to collect a chemical image of a sample that is in contact with the Ge hemisphere. The collected image is then corrected to produce a corrected chemical image.Type: GrantFiled: April 11, 2011Date of Patent: August 27, 2013Assignee: Thermo Electron Scientific Instruments LLCInventors: Francis J. Deck, Koichi Nishikida, Federico Izzia
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Publication number: 20130063714Abstract: A novel emission and transmission optical spectrometer is introduced herein, which is capable of optically interrogating solid or liquid samples of organic, inorganic or polymeric chemistry, for pharmaceutical research, forensic and liquid analyses, used for identification, purity check, and/or structural study of chemicals. The beneficial aspects of the system are a single sample compartment as confined within the walls of the spectrometer housing, a more compact accessory, and the capability of making both emission (e.g., Raman and Fluorescence) and Infrared (IR, NIR) transmission measurements at designed sample points.Type: ApplicationFiled: September 10, 2012Publication date: March 14, 2013Inventors: Federico IZZIA, Michael S. BRADLEY
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Publication number: 20120306998Abstract: A novel arrangement of Schwarzschild Cassegrainian objective coupled with a far-field visible imaging system that does not interfere with the interrogating (IR) beam is introduced. Typical (IR) microscopes that incorporate a Cassegrainian objective have difficulty in locating desired target sample regions based on the inherent limited field-of-view. Because commonly applied visible imaging accessories upstream must use the same numerical aperture based on the reflective geometry, such systems also suffer a limited field of view. To overcome such difficulties, the novel embodiments herein involve placing a visible camera with its optical axis collinear with the IR and primary visible beampath of the microscope but outside the optical path that provides the (IR) image magnification.Type: ApplicationFiled: June 1, 2011Publication date: December 6, 2012Inventors: Dennis E. Merrill II, Federico Izzia
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Publication number: 20120259599Abstract: A method and corresponding apparatus provide correction of chemical images collected with a germanium hemisphere ATR microscope. A modeled is developed for rays passing through a simulated germanium (Ge) hemisphere attenuated total reflection (ATR) microscope. The model determines a data set for rays reaching the detector plane. Movement of the hemisphere is simulated along a first axis between each data set determination. A calculated background spectrum is produced by multiplying the percentage of rays by a background spectrum to produce a calculated background spectrum. A real Ge hemisphere ATR microscope having parameters that substantially match those of the simulated Ge hemisphere microscope is then used to collect a chemical image of a sample that is in contact with the Ge hemisphere. The collected image is then corrected to produce a corrected chemical image.Type: ApplicationFiled: April 11, 2011Publication date: October 11, 2012Inventors: Francis J. DECK, Federico IZZIA, Koichi Nishikida
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Patent number: 7698098Abstract: An unknown spectrum obtained from infrared or other spectroscopy can be compared to spectra in a reference library to find the best matches. The best match spectra can then each in turn be combined with the reference spectra, with the combinations also being screened for best matches versus the unknown spectrum. These resulting best matches can then also undergo the foregoing combination and comparison steps. The process can repeat in this manner until an appropriate stopping point is reached, for example, when a desired number of best matches are identified, when some predetermined number of iterations has been performed, etc. This methodology is able to return best-match spectra (and combinations of spectra) with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.Type: GrantFiled: February 18, 2008Date of Patent: April 13, 2010Assignee: Thermo Electron Scientific Instruments LLCInventors: Gary L. Ritter, William J. McCarthy, Kathleen A. Larson, Alexander I. Grenov, Federico Izzia
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Publication number: 20090210194Abstract: An unknown spectrum obtained from infrared or other spectroscopy can be compared to spectra in a reference library to find the best matches. The best match spectra can then each in turn be combined with the reference spectra, with the combinations also being screened for best matches versus the unknown spectrum. These resulting best matches can then also undergo the foregoing combination and comparison steps. The process can repeat in this manner until an appropriate stopping point is reached, for example, when a desired number of best matches are identified, when some predetermined number of iterations has been performed, etc. This methodology is able to return best-match spectra (and combinations of spectra) with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.Type: ApplicationFiled: February 18, 2008Publication date: August 20, 2009Inventors: Garry L. Ritter, William J. McCarthy, Kathleen A. Larson, Alexander I. Grenov, Federico Izzia
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Patent number: 7496220Abstract: In a spectroscopic microscope, a video image of a specimen is analyzed to identify regions having different appearances, and thus presumptively different properties. The sizes and locations of the identified regions are then used to position the specimen to align each region with an aperture, and to set the aperture to a size appropriate for collecting a spectrum from the region in question. The spectra can then be analyzed to identify the substances present within each region of the specimen. Information on the identified substances can then be presented to the user along with the image of the specimen.Type: GrantFiled: August 28, 2007Date of Patent: February 24, 2009Assignee: Thermo Electron Scientific Instruments LLCInventors: Federico Izzia, Kathleen J. Schulting, Alexander Grenov
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Publication number: 20080049220Abstract: In a spectroscopic microscope, a video image of a specimen is analyzed to identify regions having different appearances, and thus presumptively different properties. The sizes and locations of the identified regions are then used to position the specimen to align each region with an aperture, and to set the aperture to a size appropriate for collecting a spectrum from the region in question. The spectra can then be analyzed to identify the substances present within each region of the specimen. Information on the identified substances can then be presented to the user along with the image of the specimen.Type: ApplicationFiled: August 28, 2007Publication date: February 28, 2008Inventors: Federico Izzia, Kathleen J. Schulting, Alexander Grenov