Patents by Inventor Federico PIETROCOLA

Federico PIETROCOLA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and pharmaceutical compositions for modulating autophagy in a subject in need thereof
    Patent number: 11040052
    Abstract: The present invention provides novel methods for the modulation of autophagy and the treatment of autophagy-related diseases, including cancer, neurodegenerative diseases, liver diseases, muscle diseases and pancreatitis.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: June 22, 2021
    Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Guido Kroemer, Guillermo Marino, Federico Pietrocola
  • USE OF TRIETHYLENETETRAMINE (TETA) FOR THE THERAPEUTIC INDUCTION OF AUTOPHAGY
    Publication number: 20200360305
    Abstract: Autophagy is a universal anti-aging mechanism the chronic induction of which can extend the health span and lifespan of mammals Here the inventors show that triethylenetetramine (TETA), also called trientine, a drug that is approved for the treatment of Wilson disease, can induce autophagy in mouse tissues in vivo. In particular, chronic autophagy stimulation by TETA can improve the metabolic characteristics of mice kept on a high-fat or high-sugar diet without reducing their food uptake, yet attenuating their weight gain. TETA attenuates adioposity, signs of obesity related type-2 diabetes and hepatosteatosis. TETA also mediates hepatoprotective effects against acute ethanol intoxication. Hence, TETA can be considered as a novel autophagy-inducing agent and thus can be used for the treatment of various diseases and in particular for the treatment of obesity, as well as obesity-related comorbidities.
    Type: Application
    Filed: November 30, 2018
    Publication date: November 19, 2020
    Inventors: Guido KROEMER, Federico PIETROCOLA
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING AUTOPHAGY IN A SUBJECT IN NEED THEREOF
    Publication number: 20190008884
    Abstract: The present invention provides novel methods for the modulation of autophagy and the treatment of autophagy-re lated diseases, including cancer, neurodegenerative diseases, liver diseases, muscle diseases and pancreatitis.
    Type: Application
    Filed: June 19, 2018
    Publication date: January 10, 2019
    Inventors: Guido KROEMER, Guillermo MARINO, Federico PIETROCOLA
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING AUTOPHAGY IN A SUBJECT IN NEED THEREOF
    Publication number: 20160250249
    Abstract: The present invention provides novel methods for the modulation of autophagy and the treatment of autophagy-related diseases, including cancer, neurodegenerative diseases, liver diseases, muscle diseases and pancreatitis.
    Type: Application
    Filed: October 3, 2014
    Publication date: September 1, 2016
    Inventors: Guido KROEMER, Guillermo MARINO, Federico PIETROCOLA