Patents by Inventor Federico Sesti

Federico Sesti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SCREENING FOR AGENTS THAT TARGET THE ACTIN CYTOSKELETON USING C. ELEGANS EXPOSED TO HEAT SHOCK
    Publication number: 20200080991
    Abstract: Provided herein are screening methods that utilize transgenic nematodes exposed to heat shock conditions, such as agents that increase stability of F-actin. The transgenic nematodes used can be in a wild-type background, functionally deleted for OSG-1, or express human ARHGEF10 in an OSG-1 background. Such transgenic nematodes also express a fluorescent protein, such as GFP. Such methods are in some examples high throughput and automated. Also provided are recombinant nematodes and kits that can be used with such methods.
    Type: Application
    Filed: January 19, 2018
    Publication date: March 12, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Federico Sesti, Rahul Patel
  • MinK-related genes, formation of potassium channels and association with cardiac arrhythmia
    Patent number: 6864364
    Abstract: The present invention is directed to genes and gene products related to Min-K which form ion channels and to a process for diagnosis of ion channel disorders, including long QT syndrome (LQT). For example, KCNE2 forms IKr potassium channels and is associated with LQT. LQT is diagnosed in accordance with the present invention by analyzing the DNA sequence of KCNE2 of an individual to be tested and comparing the respective DNA sequence to the known DNA sequence of a normal KCNE2 gene. Alternatively, these MinK-related genes of an individual to be tested can be screened for mutations which cause ion channel disorders, including LQT. Prediction of ion channel disorders, including LQT, will enable practitioners to prevent the disorders using existing medical therapy. This invention is further directed to the discovery that the HERG and KCNE2 (also known as MiRP1) proteins coassemble to form a cardiac IKr potassium channel.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: March 8, 2005
    Assignees: University of Utah Research Foundation, Yale University
    Inventors: Igor Splawski, Mark T. Keating, Geoffrey W. Abbott, Federico Sesti, Steve A. N. Goldstein
  • MinK-related genes, formation of potassium channels and association with cardiac arrhythmia
    Publication number: 20040197818
    Abstract: The present invention is directed to genes and gene products related to Min-K which form ion channels and to a process for diagnosis of ion channel disorders, including long QT syndrome (LQT). For example, KCNE2 forms IKr potassium channels and is associated with LQT. LQT is diagnosed in accordance with the present invention by analyzing the DNA sequence of KCNE2 of an individual to be tested and comparing the respective DNA sequence to the known DNA sequence of a normal KCNE2 gene. Alternatively, these MinK-related genes of an individual to be tested can be screened for mutations which cause ion channel disorders, including LQT. Prediction of ion channel disorders, including LQT, will enable practitioners to prevent the disorders using existing medical therapy. This invention is further directed to the discovery that the HERG and KCNE2 (also known as MiRP1) proteins coassemble to form a cardiac IKr potassium channel.
    Type: Application
    Filed: May 11, 2004
    Publication date: October 7, 2004
    Applicants: The University of Utah Research Foundation, Yale University
    Inventors: Igor Splawski, Mark T. Keating, Geoffrey W. Abbott, Federico Sesti, Steve A. N. Goldstein