Abstract: The present invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts particulary suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles.Said salts correspond to the general formula:SAMe.n(CH.sub.2).sub.m (SO.sub.3 H).sub.2 (I)where n can vary from 1 to 2 and m can vary from 3 to 12.The process for producing said salts consists of the following stages: a) enriching the starting yeast with SAMe; b) lysing the cells and recovering a solution rich in SAMe (cell lysate); c) prepurifying the cell lysate by ultrafiltration; d) passing the prepurified lysate through a column of weak acid ion exchange resin and eluting with the required disulphonic acid; e) passing the eluate of said column through a colum of absorption resin and washing with the required disulphonic acid; f) concentrating the eluate of the later column by reverse osmosis; g) drying the concentrated solution.

Abstract: The present invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts particularly suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles.Said salts correspond to the general formula:SAMe.n(CH.sub.2).sub.m (SO.sub.3 H).sub.2 (I)where n can vary from 1 to 2 and m can vary from 3 to 12.The process for producing said salts consists of the following stages: (a) enriching the starting yeast with SAMe; (b) lysing the cells and recovering a solution rich is SAMe (cell lysate); (c) prepurifying the cell lysate by ultrafiltration; (d) passing the prepurified lysate through a column of weak acid ion exchange resin and eluting with the required disulphonic acid; (e) passing the eluate of said column through a column of absorption resin and washing with the required disulphonic acid; (f) concentrating the eluate of the latter column by reverse osmosis; (g) drying the concentrated solution.