Abstract: Methods and systems described herein enable robust and facile multi-site base editing through pooled editing, suitable for one-step encoding of information. gRNAs show robust editing in pools and demonstrate simultaneous multi-site editing across >100 genomic sites. Additionally, individual stem cells with more than two dozen edits can be obtained with minimal screening.

Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.

Abstract: The present application relates to a cell detection method and apparatus, a device, a readable storage medium, and a program product. The method may include: obtaining a first image, where the first image includes a first area where a cell is located; determining a first edge line of the cell based on the first area; and determining a detection result of the cell based on grayscale values corresponding to pixels in a preset area in the first image, where the detection result is used to indicate whether the cell includes a bottom support sheet, and the preset area is an area within a preset range from the first edge line.

Abstract: The present disclosure provides a light-emitting device and a manufacturing method thereof, a taillight and a vehicle. The light-emitting device includes at least one light-emitting element located on one side of a backplane, wherein a wavelength of a first light emitted by each light-emitting element is 500 nm to 580 nm; a wavelength conversion layer located on one side of the at least one light-emitting element away from the backplane and configured to emit a second light with a different color from the first light under the excitation of the first light; and a first optical structure located on one side of the wavelength conversion layer away from the backplane, and including one or more optical elements, each of which is configured to focus the second light along a direction perpendicular to the backplane.

Abstract: The present application provides a treatment method and device for a waste plastic. A first aspect of the present application provides a treatment method for a waste plastic, including: firstly subjecting the waste plastic to a first pre-treatment to remove impurity and grease on a surface of the waste plastic, then subjecting the waste plastics to a second pre-treatment to convert a solid waste plastic into one in flow state; and finally, subjecting the waste plastic in flow state to a first cracking treatment and a second cracking treatment in sequence. Through the method provided in the present application, while cracking the waste plastic, chlorine element in the waste plastic may be removed by a multi-stage adsorption, which reduces chlorine content in the cracked oil, reduces pressure and burden in subsequent refining, and meets the limitation of the chlorine content in cracked products in downstream processes.

Abstract: An energy storage all-in-one machine and an energy storage system are provided. The energy storage all-in-one machine includes a battery, a switch box, and at least two connectors. The switch box is electrically connected to the battery; and the connectors are used for achieving capacity expansion of the energy storage all-in-one machine.

Abstract: A display panel includes a pixel definition layer on a base substrate, having a plurality of first apertures extending there-through; a light emitting layer at least partially in the plurality of first apertures; an encapsulating layer on a side of the pixel definition layer and the light emitting layer away from the base substrate; a bank layer on a side of the encapsulating layer away from the base substrate, having a plurality of second apertures extending there-through; and a color conversion layer at least partially in the plurality of second apertures. The color conversion layer comprises a plurality of color conversion blocks. A minimum height of a bottom of the bank layer with respect to a surface of the base substrate is greater than a minimum height of a bottom of a respective color conversion block with respect to the surface of the base substrate.

Abstract: Provided are an antibody targeting BCMA, a bispecific antibody targeting BCMA and CD3, and applications thereof. The antibody targeting BCMA comprises two heavy chain variable regions, the heavy chain variable regions comprising HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 22, SEQ ID NO: 33 and SEQ ID NO: 42, or HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 37 and SEQ ID NO: 41. The antibody effectively targets human BCMA and binds to cynomolgus BCMA; the bispecific antibody effectively targets both human BCMA and human CD3, and can bind to cynomolgus BCMA and cynomolgus CD3.

Abstract: In some embodiments, the techniques described herein relate to a method including: reading, by a generative artificial intelligence (AI) agent executed by one or more processors, a property file including one or more current configurations of a configurable environment, the property file comprising one or more text entries describing an application of the configurable environment and one or more related secret entities; identifying, by the generative artificial intelligence (AI) agent, changes to the one or more current configurations; and implementing the identified changes.

Abstract: Provided is a display panel. The display panel has a display region, and includes: a base substrate; and a plurality of pixel circuits arrayed on a side of the base substrate, wherein the plurality of pixel circuits include a plurality of first pixel circuits and a plurality of dummy pixel circuits; a plurality of light-emitting devices on a side of the plurality of pixel circuits away from the base substrate, wherein the plurality of light-emitting devices are electrically connected to the plurality of first pixel circuits in one-to-one correspondence; and a plurality of data signal lines and a plurality of redundant signal lines that are disposed in the display region, wherein an extension direction of the plurality of data signal lines is coincident with an extension direction of the plurality of redundant signal lines.

Abstract: An insoluble substance measurement system and an insoluble substance content measurement method are disclosed. The system comprises a box body, and a leaching system, a sample injection system, and a separation system that are located in the box body; the leaching system comprises a first leaching bottle and a second leaching bottle; the sample injection system comprises at least one sample injection tube; the separation system comprises at least one separation column; the outlet of the first leaching bottle is connection with the sample injection tube, and the outlet of the first leaching bottle is further connection with the opening of the upper end of the separation column; the sample injection pipe is connection with the opening of the upper end of the separation column; and the outlet of the second leaching bottle is connection with the opening of the upper end of the separation column.

Abstract: The present disclosure relates to a howling suppression method. The method includes obtaining audio data and obtaining a first sub-band signal of frame signal in the audio data. The method further includes obtaining a second sub-band signal of the first howling sub-band signal according to the first howling sub-band signal in response that the first sub-band signal is the first howling sub-band signal, and suppressing the howling frame signal in response that the second sub-band signal is the second howling sub-band signal and in response that the frame signal is the howling frame signal.

Abstract: A display substrate includes conductive layers including data lines, connection lines and fan-out lines. A connection line crosses at least one data line and is insulated from the crossed data line(s). A first fan-out line is electrically connected to the connection line, and a second fan-out line is electrically connected to an end of a second data line proximate to a fan-out region. The first fan-out line includes a transfer line. The fan-out region includes a first fan-out region and a second fan-out region, and the transfer line is located in the second fan-out region. The transfer line and second fan-out lines are located in different conductive layers, and crosses at least one second fan-out line. The transfer line includes a main body and two connection ends, and the main body is located on a side of the two connection ends proximate to the display region.

Abstract: Methods, systems, and devices for increased file loads using file based optimization (FBO) and prefetch within a memory system are described. A system may support using a prefetch command to prioritize prefetching for artificial intelligence (AI) related data (or other high priority data). A host system may transmit a prefetch command for the AI-related data before performing one or more AI operations that use the data. In response, the memory system may prefetch the AI-related data and store the data in a cache. The storage of the AI-related data in the cache may be prioritized over other data types associated with lower priorities. The host system may transmit an FBO command to defragment the AI-related data in the memory system prior to the prefetch, which may reduce latency of the prefetch.

Abstract: Methods, systems, and devices for techniques for a sequential write protection mode in a memory system are described. A memory system may receive one or more commands to write data to associated sequential memory addresses using a write automation block (WAB) while monitoring the addresses of the data. In the case that a write command may be associated with a non-sequential memory address, the memory system may store an associated pointer to a cache. The memory system may continue to write data indicated via incoming commands using the WAB until the memory system detects and writes the sequential command or a threshold quantity of commands have been received. If the threshold is reached prior to receiving the missing command, the memory system may disable the WAB and transmit an error message. The memory system may block and return error messages to any subsequent commands until the missing command is received.

Abstract: An implementation of the present disclosure provides a memory controller, a memory system, a system and its operating method, and a storage medium; wherein the memory controller is configured to obtain a first result based on a first set of read data and a second set of read data; obtain a second result based on a third set of read data and a fourth set of read data; perform a logical operation on the first result and the second result to obtain first flip information; perform a decoding operation based on the first flip information.

Abstract: A display panel which includes a substrate; a functional layer, the functional layer having a body portion and a groove formed by a recess in a surface of the body portion away from the substrate; and an insulating layer, located on one side of the functional layer away from the substrate, the insulating layer having a first sub-layer and a second sub-layer which are stacked, the second sub-layer having a first hole penetrating therethrough, and an orthographic projection of the groove on the substrate being located within an orthographic projection of the first hole on the substrate.