Abstract: The present disclosure introduces intranasal (IN) pharmaceutical formulations having naloxone or an opioid antagonist as the active agent, and an absorption enhancer, such as a bile acid, or a salt thereof, for IN delivery. The bile acid, or salt thereof, enhances absorption of naloxone or an opioid antagonist into the bloodstream of a human subject.

Abstract: A high-efficiency particle analysis method includes the following steps: taking representative air-dried samples and measuring a moisture content; boiling, sieving, weighing and adding a dispersant; conducting a particle analysis test; reading four readings of 1st to 59th and 60th to 90th samples; and drawing a particle size distribution curve showing the relationship between the particle size and the percentage of below a certain diameter. According to the method, a time difference is used to change the measurement mode, and the four readings of the 59th and 90th samples are read in a cycling manner; and a novel test method is provided on the premise of ensuring quality, thus greatly improving the efficiency of a particle analysis test and meeting production requirements.

Abstract: A multi-disulfide-bond long-chain peptide with neuroprotective activity can reduce cellular calcium influx by inhibiting glutamate receptors to protect cortical neurons from excitotoxicity induced by glutamate. It can be an effective neuroprotective agent.

Abstract: Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg/mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg/mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg/mL sodium citrate dihydrate, 3.3 mg/mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg/mL of sodium metabisulfite, and 4 ?g/mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg/mL of epinephrine and other ingredients.

Abstract: Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg/mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg/mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg/mL sodium citrate dihydrate, 3.3 mg/mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg/mL of sodium metabisulfite, and 4 ?g/mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg/mL of epinephrine and other ingredients.

Abstract: The present disclosure provides NMR relaxation methods for characterizing iron carbohydrate drug products. The methods measure 13C and 1H nuclei relaxation parameters such as T1 and PWHH include performing 2D T1 NMR, 1D 13C NMR and 1H NMR to characterize certain physiochemical properties of iron sucrose drug products, for purposes of assessing bioequivalence between a tested iron sucrose product and a comparator product. The disclosure further provides a novel Fe(III)/Fe(II) reduction method using a new reducing agent Na2S2O5 and an 1H NMR method to monitor the Fe(III)/Fe(II) reduction process.

Abstract: An apparatus comprising a first substrate comprising a nanostructured surface, thereby forming an optical metasurface; a mirror formed on a second substrate; and a mechanism arranged to move the first and second substrates relative to one another. The mechanism alters a separation between the first and second substrates between a first separation distance and at least a second separation distance. At the first separation distance the optical metasurface performs a first manipulation of incident light and at the second separation distance the optical metasurface does not perform the first manipulation of incident light. An optical system and a method are also described.

Abstract: Disclosed herein are pharmaceutical formulations including epinephrine that have increased epinephrine retention over long-term storage, e.g., 30-months. In one aspect, a formulation includes: one or more of 0.1 mg/mL of epinephrine or a pharmaceutically acceptable salt thereof provided without any overage, a tonicity regulating agent including 8.2 mg/mL of sodium chloride, a pH adjusting agent including a mixture of 1.5 mg/mL sodium citrate dihydrate, 3.3 mg/mL of citric acid monohydrate, and, optionally, an as-needed amount of sodium hydroxide to maintain the pH level of the formulation within a range of 3.6 to 4.0, 0.075 mg/mL of sodium metabisulfite, and 4 ?g/mL of ethylene diamine tetra-acetate disodium. The formulation has an API recovery of 94.5% or more after at least 30 months of storage at long-term storage conditions defined as 25° C.±2° C. at 1 atmosphere. In addition, in another aspect, a formulation includes 1 mg/mL of epinephrine and other ingredients.

Abstract: Disclosed are a compound preparation for neuranagenesis, and a preparation method therefor and the use thereof. The compound preparation for neuranagenesis comprises the raw medicinal materials in parts by weight: 10-20 parts of raw Astragali radix, 10-20 parts of Rehmaimiae Radix praeparata, 10-20 parts of Actyranthes bidentata, 6-15 parts of Jujubae fructus, 6-15 parts of Lycii fructus, 6-15 parts of parched Ziziphi spinosae semen, 6-12 parts of Angelicae smensis radix, 3-9 parts of Carthami flos, 6-15 parts of Poria, 6-15 parts of parched Atractylodis macrocephalae rhizoma and 10-20 parts of Zaocys. The compound preparation can be used for preparing drugs to treat nerve damage diseases, and can be prepared into oral liquids, granules, dissolved granules and tablets.

Abstract: Disclosed is a device for evaluating damage of fracturing fluid to reservoir and operation method thereof, the device includes a liquid storage tank, a suction tube, a chromatography device, a bracket, a receiving container and a height adjuster; the disclosure has the following beneficial effects: since different liquids pass through the porous medium at different time and speed and the silica gel particles will not expand when immersed in the liquid, a porous structure is formed by placing silica gel particles of different sizes to simulate the pore-throat structure of unconventional oil and gas reservoirs, hence removing the influence of fracturing fluid on the hydration and expansion damage of the reservoir matrix, by testing the time and flow rate of different fracturing fluids flowing through the silica gel pores, the degree of damage caused by fracturing fluids to unconventional oil and gas reservoirs is evaluated.

Abstract: Methods are disclosed for producing highly purified recombinant human insulin (RHI) having a purity of 99.0% (w/w) or greater, a Total Impurity (not including the related substance desamido AsnA21-RHI, as specified by USP) of 0.8% (w/w) or less, and an impurity C of 0.1% (w/w) or less. Also disclosed are API compositions of highly purified RHI having a purity of 99.0% (w/w) or greater, a Total Impurity of 0.8% (w/w) or less, and an impurity C of 0.1% (w/w) or less.

Abstract: Disclosed is a method for determining three-dimensional in-situ stress based on displacement measurement of borehole wall, including the following steps: pumping the prefluid and the sand-carrying fluid into the target interval, and injecting the biological oil displacement agent into the target interval in sequence; pumping temporary plugging agent into the target layer to implement crack plugging diverting; pumping the sand-carrying liquid into the target interval, and injecting the biological oil displacement agent into the target interval. The beneficial effect of the technical scheme proposed in this disclosure is: by injecting oil displacement agent to fracturing fluid, the temporary plugging diverting fracturing is integrated constructed with enhanced oil recovery, at the same time, it can overcome the incomplete removal of temporary plugging agent and the water lock effect of fracturing fluid caused by diverting fracturing.

Abstract: Some embodiments of the invention provide methods that can create large area complex patterns for nanoimprint molds without or with very litter of the use of the charged beam or photon beam direct-writing of nanostructures. Some embodiments of the invention use (i) Fourier nanoimprint patterning (FNP), (ii) edge-guided nanopatterning (EGN), and (iii) nanostructure self-perfection, and their combinations.

Abstract: An enhanced oil recovery method includes: screening out implementation well that meet the requirements of a preset standard; selecting the target interval that can be used for enhanced oil recovery in the implementation well; obtaining the reservoir parameters and perforation parameters of the target interval, so as to divide the target interval into several groups of swallowing and exhaling segments, injecting the infection liquid containing and simmer the well for a period of time; and after the well simmering, the oil-water mixture replaced by the injection fluid is produced from each exhaling segment.

Abstract: A control method for data transmission and a terminal are provided. The control method for data transmission includes: determining, when a terminal has established a user-plane bearer link with a network and before transmitting data to be transmitted, whether or not a destination address of the data to be transmitted is recorded in a pre-created address whitelist; acquiring, if the destination address of the data to be transmitted is not recorded in the address whitelist, an application identifier corresponding to the data to be transmitted, and conducting access control decision based on the application identifier to obtain a decision result; and transmitting, when the decision result indicates that transmission of the data to be transmitted is permitted, the data to be transmitted through the user-plane bearer link.

Abstract: A vehicle clustering method includes: acquiring vehicle dynamic information, the vehicle dynamic information including vehicle positions and vehicle speeds; clustering vehicles based on the vehicle dynamic information; calculating, based on the vehicle dynamic information, a link reliability and a link stability of the vehicles in a cluster; calculating, based on the link reliability and the link stability, a selection priority index for a cluster head; and selecting a vehicle with a largest selection priority index in the cluster as a cluster head.

Abstract: Disclosed is a method for determining three-dimensional in-situ stress based on displacement measurement of borehole wall, including the following steps: pumping the prefluid and the sand-carrying fluid into the target interval, and injecting the biological oil displacement agent into the target interval in sequence; pumping temporary plugging agent into the target layer to implement crack plugging diverting; pumping the sand-carrying liquid into the target interval, and injecting the biological oil displacement agent into the target interval. The beneficial effect of the technical scheme proposed in this disclosure is: by injecting oil displacement agent to fracturing fluid, the temporary plugging diverting fracturing is integrated constructed with enhanced oil recovery, at the same time, it can overcome the incomplete removal of temporary plugging agent and the water lock effect of fracturing fluid caused by diverting fracturing.

Abstract: A control method for data transmission and a terminal are provided. The control method for data transmission includes: determining, when a terminal has established a user-plane bearer link with a network and before transmitting data to be transmitted, whether or not a destination address of the data to be transmitted is recorded in a pre-created address whitelist; acquiring, if the destination address of the data to be transmitted is not recorded in the address whitelist, an application identifier corresponding to the data to be transmitted, and conducting access control decision based on the application identifier to obtain a decision result; and transmitting, when the decision result indicates that transmission of the data to be transmitted is permitted, the data to be transmitted through the user-plane bearer link.

Abstract: Disclosed in the invention is an emergency message transmission method based on D2D communication in IoV. Firstly, priority indexes are established for a set of vehicles within a safety range of a certain vehicle, and D2D connection pairs are established in ascending order of the priority indexes to transmit messages; and then, distance prediction is performed on the set of vehicles outside the safety range, priority indexes are established according to predicted distances, and D2D connection pairs are established in ascending order of the priority indexes to transmit messages. If same priority indexes appear, vehicles on the same lane are selected first. The invention implements timely transmission of safety warning information on basis of D2D communication, and performs safety warning, thereby solving the technical problem of inability to transmit safety information in time, and improving transmission performance of traffic messages. Therefore, the invention has high reliability and real-time properties.