Abstract: The present invention provides a stable and reliable biosensor (GO-TNA) composed of chemically modified TNA capture probes onto graphene oxide (GO) for detecting and imaging of target nucleic acids in vitro and in vivo, discriminating single nucleobase mismatch and monitoring target miRNA dynamic changes. The TNA capture probes in the invention brings significant improvement by 1000 times in the detection limit when compared to TNA probes itself. This detection platform is facile and cost-effective to prepare, which are critical advantages for real-time analysis, and thus brings new opportunities in the field of disease diagnosis for rapid and accurate detecting and imaging of a variety of disease-related nucleic acid molecules at the in vivo level. Apart from healthcare, they may also lead to potential applications in the areas of environmental analysis and food safety through detection of pesticides, antibiotics, or even foodborne pathogenic agents.

Abstract: Provided is a display device. The display device includes a display substrate and a drive assembly; wherein the display substrate has a first bonding region, and the drive assembly has a second bonding region corresponding to the first bonding region; and the display substrate includes a first limiting assembly disposed outside the first bonding region, and the drive assembly includes a second limiting assembly disposed outside the second bonding region and engaged with the first limiting assembly; wherein the first limiting assembly is configured to engage with the second limiting assembly to restrict relative movement between the drive assembly and the display substrate during bonding the first bonding region to the second bonding region.

Abstract: A display module includes a display panel and a support backplane located on a side of the display panel where a non-display surface of the display panel is located. The support backplane has a first region and a second region disposed on a periphery of the first region. At least a portion of a portion, located in the second region, of the support backplane is etched away to form at least one groove.

Abstract: Provided are a printing device and a method for an LED retaining wall of a display panel. The device includes a motion control system, an adsorption apparatus, a measuring system, a Z-axis controller, a target multi-needle module and a target station. The motion control system is configured to control printing of a target LED retaining wall on an upper surface of a target substrate on the target station. The adsorption apparatus is configured to make a lower surface of the target substrate adsorbed onto a sucker by a vacuum pump. The measuring system includes a sensor and a sensor controller, and the sensor is configured to measure flatness data of the target substrate. The Z-axis controller is configured to control a printing receiving distance between the target multi-needle module and the upper surface of the target substrate.

Abstract: A synthesis and an application of a phosphatase degrader are provided. The phosphatase degrader is a compound represented by formula I, or a salt thereof, or a deuterated compound thereof, or a stereoisomer thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof. The compound can be used as a phosphatase degrader, especially as an SHP2 protein degrader, can treat malignant diseases such as tumors, and has good application prospects.

Abstract: Disclosed are a compound as represented by general formula (I) or a stereoisomer, deuterated compound, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, and an intermediate thereof, and the use thereof in AR or AR splicing mutant-related diseases such as cancer.

Abstract: A short contact reaction system for preparing ethylene and propylene from methanol includes an MTO short contact reactor, a riser reactor, a dense bed, and a stripper. The MTO short contact reactor has the following components coaxially distributed from inside to outside: a methanol feeding pipeline, a filter pipe wall, a product gas channel, and a catalyst distributor arranged at the top of the reactor, and a seal pipe arranged at the bottom of the reactor. The seal pipe is located in the stripper. The diameter at the top of the product gas channel is smaller than the diameter at the bottom of the product gas channel. Methanol is in crossflow contact with the descending coked catalyst II in the MTO short contact reactor.

Abstract: A semiconductor device and a display panel are disclosed. The semiconductor device includes an insulating substrate and a thin film transistor on the insulating substrate. The thin film transistor includes a protrusion and an active layer. The protrusion includes a first sub-protrusion on the insulating substrate, and a second sub-protrusion on the first sub-protrusion. The second sub-protrusion completely covers a side of the first sub-protrusion away from the insulating substrate. The active layer includes a first ohmic contact portion, a channel portion connected to the first ohmic contact portion, and a second ohmic contact portion connected to the channel portion. The first ohmic contact portion is at least partially disposed on the insulating substrate. The channel portion is fitted to a side surface of the first sub-protrusion and a side surface of the second sub-protrusion.

Abstract: The present disclosure provides an LED lamp with a double-segment-nested cup design, the LED lamp comprising a power module and a light source module assembled together; wherein the light source module comprises a first cylindrical cup segment, an LED board and an optical lens module installed inside the first cylindrical cup segment; wherein the power supply module comprises a second cylindrical cup segment, an LED driver and an external power supply connector installed inside the second cylindrical cup segment, and wherein the second cylindrical cup segment is provided with an open end and an opposite convergent end.

Abstract: The present disclosure provides a battery pack, including: a battery box, a plurality of battery modules, a cooling plate, and a buffering member. Each battery module includes a plurality of battery cells and a plurality of busbars. Each battery cell includes an electrode assembly and a battery housing. The battery cells are laid flat. When the electrode assembly is of a wound structure and is flat, and outer surfaces of the electrode assembly include two flat surfaces. The two flat surfaces are opposite to each other in a vertical direction. Alternatively, when the electrode assembly is of a laminated structure, a first electrode plate, a separator, and a second electrode plate are stacked in a vertical direction. Therefore, the electrode assembly of the battery cells applies a greatest expansion force in the vertical direction during charge and discharge.

Abstract: Systems and methods are provided for notifying users about videos in a playback sequence. The systems and methods determine that a video that meets a criterion is currently available on a video server associated with a messaging client. In response to determining that the video that meets the criterion is currently available, the messaging client on the client device prefetches a sequence of videos from a recommendation engine that match a profile of a user associated with the messaging client. The recommendation engine is being used to provide sequence of videos to a video playback graphical user interface (GUI) that automatically plays back the videos in the sequence. The systems and methods determine that the video that meets the criterion is in a first position in the sequence of videos and, in response, present a notification that indicates the availability of the video on the video playback GUI.

Abstract: Disclosed is a LATCH connector. A rotating piece is linked to an unlocking assembly, which is provided with an unlocking button, an unlocking insert and green display parts; the unlocking insert is inserted into a front portion of the unlocking button, and button parts and the green display parts are disposed in a rear portion of the unlocking button; and a first latch hook which bends inwards with the rotation of the rotating piece is disposed on a front portion of the rotating piece, and a second latch hook which is in contact with the unlocking insert is disposed on a rear portion of the rotating piece. The LATCH connector can be installed smoothly and rapidly, and can be locked and unlocked quickly; and the state of the LATCH connector can be displayed more visually, and the safety in use is guaranteed.

Abstract: This application provides a communication method and apparatus. The method includes: A first node receives a beam set and first indication information from a second node, where the beam set includes at least one beam. The first node determines, based on the first indication information, identification information of at least one beam that needs to be forwarded by the first node in the beam set. The first node forwards, based on the identification information of the at least one beam that needs to be forwarded by the first node in the beam set and receiving time information of the at least one beam that needs to be forwarded by the first node, the at least one beam that needs to be forwarded by the first node. The method is applied to a smart repeater, to implement smart beam forwarding by the repeater.

Abstract: A humidifying apparatus, including a water tank, a water pump, a wet curtain assembly, and a water passage structure. The water tank has a water storage chamber. A water inlet of the water pump is adapted to communicate with the water storage chamber. The wet curtain assembly is disposed above the water storage chamber and has a water supply port and a drainage port. The water passage structure is an integrated structure and includes a water inlet channel and a return water channel spaced apart from each other. An upper end of the water inlet channel is connected to the water supply port, and an upper end of the return water channel is connected to the drainage port.

Abstract: Provided are a vacuum distillation furnace, and a method for preparing high-purity copper particles. In view of the fact that high-purity copper prepared by the traditional method in the current industrial production has an unsatisfactory purity, a high impurity content, and a complicated composition, a vacuum distillation method is adopted. During the vacuum distillation method, most of valuable metals in a copper matrix are volatilized and enter into a gas phase, such that the metals are separated from the copper matrix, thereby allowing the purification of copper; and copper powder particles volatilized to a condensation plate have a smooth surface and a purity of 5 N grade or more.

Abstract: Disclosed is a method for removing impurity mercury from crude selenium. The method includes: mixing a vulcanizing agent with a crude selenium slag that is crushed to not more than 200 mesh uniformly, and performing briquetting to obtain a mixed material; adding the mixed material into a sealed furnace, and subjecting the mixed material to vulcanization by heating under an inert atmosphere to obtain a vulcanized selenium; subjecting the vulcanized selenium to primary vacuum distillation, such that selenium is converted into a gas phase and collected in a form of a volatile, and generated mercury sulfide and valuable elements are enriched in a resulting residue; and subjecting the selenium to secondary distillation to further remove mercury.

Abstract: A touch display substrate and a touch display apparatus are provided. The touch display substrate including: a display region and a non-display region, the display region including a first display region and a second display region, the first display region surrounding at least one side of the second display region; the touch display substrate includes a base substrate and a display structure layer and a touch structure layer disposed on the base substrate sequentially; the first display region includes a first touch assembly, and the second display region includes a second touch assembly; the display structure layer includes multiple pixel circuits located in the first display region and multiple light emitting elements located in the first display region and second display region; the first touch assembly is located in the touch structure layer, and the second touch assembly is located in the display structure layer and/or the touch structure layer.

Abstract: A method for inverting a formation wave impedance using DAS borehole seismic data, including: acquiring an initial magnitude at a time window after the initial arrival time of seismic wavefield data in a well; mapping the initial magnitude to a relative wave impedance; and correcting the relative wave impedance to obtain an inverted wave impedance. Also provided are an apparatus for inverting a formation wave impedance using DAS borehole seismic data, a device, and a computer-readable storage medium.

Abstract: A gate-all-around transistor and a method for manufacturing the same. The gate-all-around transistor comprises: a semiconductor substrate; an active structure disposed on the semiconductor substrate, where the active structure comprises a source, a drain, and a channel between the source and the drain; a doped epitaxial structure, where a portion of the semiconductor substrate beneath the channel is recessed to form a first groove, the first groove is fully filled with the doped epitaxial structure, and primary carriers of the doped epitaxial structure are opposite in polarity to primary carriers of the source and the drain; and a gate stack structure surrounding the channel, where a portion of the gate stack structure beneath the channel is disposed between the doped epitaxial structure and the channel.

Abstract: A display substrate includes: a base substrate; a first conducting layer; a first insulating layer, where the first insulating layer is provided with a first opening; a second conducting layer, connected to the first conducting layer through the first opening, and including a first portion and a second portion, where the first portion is located within the first opening, and the second portion is located outside the first opening and located on the side of the first insulating layer facing away from the base substrate; and an inorganic protective layer including at least a first inorganic protective layer portion located between the second portion and the first insulating layer; in a direction perpendicular to the base substrate, the thickness h1 of the first inorganic protective layer portion and the thickness h2 of the second portion satisfy the following relationship: h2=K*h1, wherein 12?K?18.