Patents by Inventor Fei Mao

Fei Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small volume in vitro analyte sensor and methods of making
    Patent number: 8083928
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: December 27, 2011
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Small volume in vitro sensor and methods of making
    Patent number: 8083929
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: December 27, 2011
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Small volume in vitro analyte sensor and methods of making
    Patent number: 8083924
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: December 27, 2011
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Redox Polymers
    Publication number: 20110306111
    Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
    Type: Application
    Filed: August 22, 2011
    Publication date: December 15, 2011
    Inventors: Fei Mao, Adam Heller
  • Redox Polymers
    Publication number: 20110303537
    Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
    Type: Application
    Filed: August 22, 2011
    Publication date: December 15, 2011
    Inventors: Fei Mao, Adam Heller
  • Redox Polymers
    Publication number: 20110303538
    Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
    Type: Application
    Filed: August 22, 2011
    Publication date: December 15, 2011
    Inventors: Fei Mao, Adam Heller
  • Transition metal complexes with (pyridyl)imidazole ligands
    Patent number: 8070934
    Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme-based electrochemical sensors. The transition metal complexes include substituted or unsubstituted (pyridyl)imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: December 6, 2011
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Fei Mao, Adam Heller
  • Life Saving Device That Can Be Inflated Automatically
    Publication number: 20110284127
    Abstract: A life saving device includes a barrel, an air bottle having a mouth mounted on the barrel, an inflation nozzle having a first end connected to the mouth and a second end connected to a life saving equipment, a breaking mechanism operable to break the mouth, a stop bar movable to abut the breaking mechanism, a control handle pivotally mounted on the barrel and connected with the stop bar, an elastic member biased between the barrel and the control handle, and at least one water-soluble cord enclosing the air bottle and the control handle. Thus, the water-soluble cord is dissolved in the water quickly so that the life saving equipment can be inflated automatically without needing a manual operation, thereby facilitating the user employing the life saving equipment during an emergency.
    Type: Application
    Filed: August 11, 2010
    Publication date: November 24, 2011
    Inventors: Tso-Fei Mao, Sen-Bin Lan
  • COMPOSITIONS AND METHODS FOR THE PROTECTION OF NUCLEOPHILIC GROUPS
    Publication number: 20110201010
    Abstract: The present invention provides compositions, methods, and kits relating to the protection and deprotection of molecules comprising nucleophilic groups, such as the protection and deprotection of thermostable polymerases. Also provided are methods of performing nucleic acid amplification using polymerases protected according to the invention.
    Type: Application
    Filed: July 2, 2009
    Publication date: August 18, 2011
    Inventors: Fei Mao, Xing Xin, Wai-Lee Leung
  • HETEROCYCLE-SUBSTITUTED XANTHENE DYES
    Publication number: 20110136201
    Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
    Type: Application
    Filed: August 4, 2010
    Publication date: June 9, 2011
    Applicant: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung, Hye Eun Hoover
  • FLUORESCENT PYRENE COMPOUNDS
    Publication number: 20110097735
    Abstract: The present invention relates to fluorescent pyrene dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
    Type: Application
    Filed: October 28, 2009
    Publication date: April 28, 2011
    Applicant: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung
  • Transition metal complexes with bidentate ligand having an imidazole ring
    Patent number: 7918976
    Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: April 5, 2011
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Fei Mao, Adam Heller
  • Biosensor Membranes Composed Of Polymers Containing Heterocyclic Nitrogens
    Publication number: 20110066019
    Abstract: Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.
    Type: Application
    Filed: November 18, 2010
    Publication date: March 17, 2011
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Fei Mao, Hyun Cho
  • Biosensor Membranes Composed of Polymers Containing Heterocyclic Nitrogens
    Publication number: 20110021896
    Abstract: Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.
    Type: Application
    Filed: September 30, 2010
    Publication date: January 27, 2011
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Fei Mao, Hyun Cho
  • SLOW RELEASE MAGNESIUM COMPOSITION AND USES THEREOF
    Publication number: 20110020443
    Abstract: The present invention provides compositions that contain magnesium and threonate, or a threonate precursor molecule, formulated for extended or modified release to provide physiological concentrations over a desired time period. The extended release or modified release form is particularly useful in providing Mg to a subject while avoiding adverse side effects such as diarrhea.
    Type: Application
    Filed: July 1, 2010
    Publication date: January 27, 2011
    Applicant: Magceutics, Inc.
    Inventors: Guosong LIU, Fei MAO
  • Biosensor Membranes Composed of Polymers Containing Heterocyclic Nitrogens
    Publication number: 20110017595
    Abstract: Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.
    Type: Application
    Filed: September 29, 2010
    Publication date: January 27, 2011
    Inventors: Fei Mao, Hyun Cho
  • Methods of Using Dyes in Association with Nucleic Acid Staining or Detection and Associated Technology
    Publication number: 20100323453
    Abstract: Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.
    Type: Application
    Filed: August 11, 2010
    Publication date: December 23, 2010
    Applicant: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung
  • DYES AND LABELED MOLECULES
    Publication number: 20100317016
    Abstract: Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.
    Type: Application
    Filed: June 22, 2010
    Publication date: December 16, 2010
    Applicants: Biotium, Inc., Allelogic Biosciences Corporation
    Inventors: Fei Mao, Wai-Yee Leung, Xing Xin
  • Transition Metal Complexes with Bidentate Ligand Having an Imidazole Ring
    Publication number: 20100288634
    Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
    Type: Application
    Filed: July 26, 2010
    Publication date: November 18, 2010
    Inventors: Fei Mao, Adam Heller
  • Small Volume In Vitro Analyte Sensor and Methods of Making
    Publication number: 20100243478
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Application
    Filed: September 29, 2009
    Publication date: September 30, 2010
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan