Patents by Inventor Fei RAN

Fei RAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250101468
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues of organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provide dare methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
    Type: Application
    Filed: June 11, 2024
    Publication date: March 27, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng ZHANG, Le CONG, Fei RAN
  • Patent number: 12258595
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: December 27, 2022
    Date of Patent: March 25, 2025
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTIT JTE OF TECHNOLOGY, UNIVERSITY OF TOKYO, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Silvana Konermann, Alexandro Trevino, Mark Brigham, Fei Ran, Patrick Hsu, Chie-Yu Lin, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani, Feng Zhang
  • Patent number: 12225764
    Abstract: A display panel, a display device, and a method for manufacturing the display panel, mitigating the problem that display panels in the prior art still have wide bezels. The display panel comprises: a display module (1); a polarizer (2) located on a light exit surface of the display module (1), at least one outer edge of the polarizer (2) being flush with an outer edge of the display module (1); and a cover plate (3) located on the surface of the polarizer (2) far away from the display module (1), the outer edges of the cover plate (3) except a binding side being flush with the outer edges of the display module (1) except the binding side.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: February 11, 2025
    Assignees: Chengdu BOE Optoelectronics Technology Co., Ltd., BOE Technology Group Co., Ltd.
    Inventors: Jiaxiang Wang, Yonghui Luo, Binfeng Feng, Zijie Zhang, Hailong Ran, Fei Li
  • Patent number: 12168789
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: January 26, 2023
    Date of Patent: December 17, 2024
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, UNIVERSITY OF TOKYO
    Inventors: Feng Zhang, Winston Yan, Osamu Nureki, Kaijie Zheng, Le Cong, Hiroshi Nishimasu, Fei Ran, Yinqing Li
  • Publication number: 20240376468
    Abstract: The present invention provides, among other things, circular guide RNA (cgRNA) compositions and methods for making same. For example, in some aspects, a method of making egRN A is provided comprising enzymatically ligating two ends of a linear guide RNA, creating a cgRNA. In some aspects, a. method is provided for making cgRNA comprising contacting a linear guide RNA with a ligating enzyme, wherein the contacting brings together a first end and a second end of the guide RN A. and wherein the ligating enzyme ligates the first and the second end of the guide RNA thus creating a cgRNA. In some aspects, circularization is carried out by self-splicing introns. In some aspects, provided are circular RNA compositions, for example, circular messenger RNA, and methods for making same.
    Type: Application
    Filed: December 1, 2023
    Publication date: November 14, 2024
    Inventors: Brian CAFFERTY, Fei RAN, Bernd ZETSCHE, Justin THOMAS, Maria MONTIEL, Krishna SAPKOTA
  • Patent number: 12110490
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: October 8, 2024
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Bernd Zetsche, Fei Ran, James E. Dahlman
  • Publication number: 20240327802
    Abstract: Provided herein are chimeric pseudotyped recombinant RABV particles, wherein the chimeric envelope protein comprises, from N-terminus to C-terminus, a non-RABV envelope protein ectodomain, a non-RABV envelope protein transmembrane domain, and a RABV C-terminal domain. Also provided are methods for their use in delivering a transgene into a target cell.
    Type: Application
    Filed: January 31, 2024
    Publication date: October 3, 2024
    Inventors: ChieYu Lin, Fei Ran, Apurva Govande
  • Publication number: 20240287532
    Abstract: The present disclosure provides genetic constructs comprising a recombinant internal ribosome entry site (IRES), which may be used as riboswitches to modulate translation of an operably-mRNA sequence encoding a protein of interest in a plant. In other aspects, the disclosure provides recombinant plant cells, methods, kits and systems that utilize the same, e.g., to provide a platform for modulating the expression of essentially any protein of interest in a plant cell.
    Type: Application
    Filed: June 11, 2021
    Publication date: August 29, 2024
    Inventors: Yanshun LIU, Brody John DEYOUNG, Shirong ZHANG, Laura SCHOUTEN, Peifeng REN, Joerg BAUER, Evan M. ZHAO, James J. COLLINS, Xiao TAN, Fei RAN, Angelo S. MAO, Helena DE PUIG GUIXE, Emma J. CHORY
  • Patent number: 12018275
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues of organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provide dare methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: June 25, 2024
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Le Cong, Fei Ran
  • Publication number: 20240035007
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Application
    Filed: December 27, 2022
    Publication date: February 1, 2024
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, University of Tokyo, President and Fellows of Harvard College
    Inventors: Silvana KONERMANN, Alexandro TREVINO, Mark BRIGHAM, Fei RAN, Patrick HSU, Chie-yu LIN, Osamu NUREKI, Hiroshi NISHIMASU, Ryuichiro ISHITANI, Feng ZHANG
  • Publication number: 20230374550
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.
    Type: Application
    Filed: February 6, 2023
    Publication date: November 23, 2023
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng ZHANG, Patrick HSU, Chie-yu LIN, Fei RAN
  • Publication number: 20230287373
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRJSPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CR.ISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
    Type: Application
    Filed: January 26, 2023
    Publication date: September 14, 2023
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, University of Tokyo
    Inventors: Feng ZHANG, Winston YAN, Osamu NUREKI, Kaijie ZHENG, Le CONG, Hiroshi NISHIMASU, Fei RAN, Yinqing LI
  • Publication number: 20230270840
    Abstract: Provided herein are recombinant negative-strand RNA virus genomes (e.g., recombinant rabies virus genomes) and recombinant negative-strand RNA viruses (e.g., recombinant rabies viruses) and methods for their use in delivering a guide RNA and, optionally, a transgene, into a target cell. Also provided are packaging systems and methods of using the packaging systems to produce recombinant negative-strand RNA viruses.
    Type: Application
    Filed: September 8, 2022
    Publication date: August 31, 2023
    Inventors: Fei Ran, ChieYu Lin
  • Publication number: 20230226969
    Abstract: A method, an apparatus and a system for lamp control of vehicle, the method includes: receiving, sent by a terminal device, position information of the terminal device, and obtaining position information of the vehicle; calculating a distance between the terminal device and the vehicle according to the position information of the terminal device and the position information of the vehicle; generating, when the distance is less than or equal to a preset distance, first information of the terminal device with respect to the vehicle, and turning on an outer lamp of the vehicle corresponding to a location of the terminal device according to the first information.
    Type: Application
    Filed: June 10, 2021
    Publication date: July 20, 2023
    Inventors: Qinghe LIU, Yang LIU, Fei RAN, Caiyun LI, Xichun WANG, Shanshan HAN
  • Publication number: 20230212592
    Abstract: The present disclosure provides genetic constructs comprising a recombinant internal ribosome entry site (IRES), which may be used as riboswitches to modulate translation of an operably-mRNA sequence encoding a protein of interest. In other aspects, the disclosure provides recombinant cells, methods, kits and systems that utilize the same, e.g., to provide a platform for modulating the expression of essentially any protein of interest in a eukaryotic cell.
    Type: Application
    Filed: June 11, 2021
    Publication date: July 6, 2023
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: James J. COLLINS, Evan M. ZHAO, Xiao TAN, Fei RAN, Angelo S. MAO, Helena DE PUIG GUIXE, Emma J. CHORY
  • Publication number: 20230110201
    Abstract: Provided herein are pseudotyped recombinant lyssavirus particles and methods for their use in delivering a transgene into a target cell. Also provided are packaging systems and methods of using the packaging systems to produce pseudotyped recombinant lyssavirus particles.
    Type: Application
    Filed: July 26, 2022
    Publication date: April 13, 2023
    Inventors: Fei Ran, ChieYu Lin
  • Patent number: 11597949
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: March 7, 2023
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Patrick Hsu, Chie-Yu Lin, Fei Ran
  • Patent number: 11597919
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: March 7, 2023
    Assignees: THE BROAD INSTITUTE INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, UNIVERSITY OF TOKYO
    Inventors: Silvana Konermann, Alexandro Trevino, Mark Brigham, Fei Ran, Patrick Hsu, Chie-yu Lin, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani, Feng Zhang
  • Patent number: 11601588
    Abstract: A take-off capture method includes: acquiring, in response to obtaining an image capturing operation triggered by a user prior to taking off, image frames within a designated duration, upon entering a take-off capture mode; filtering at least one designated image frame based on the acquired image frames, the designated image frame being an image frame where the user is at a take-off high point within the designated duration; and performing an image capturing operation and outputting a take-off capture image based on the designated image frame, when an acquiring time period does not reach the designated duration but the designated image frame is filtered based on the acquired image frames, or when an acquiring time period reaches the designated duration. The user can therefore easily and quickly obtain the take-off capture image with the best take-off posture captured by the user in the take-off process.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: March 7, 2023
    Assignee: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventors: Guosheng Li, Fei Ran
  • Patent number: 11578312
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: February 14, 2023
    Assignees: THE BROAD INSTITUTE INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, UNIVERSITY OF TOKYO
    Inventors: Feng Zhang, Winston Yan, Osamu Nureki, Kaijie Zheng, Le Cong, Hiroshi Nishimasu, Fei Ran, Yinqing Li