Abstract: Involved is an isolated antigen binding protein, being capable of binding CCR8 derived from a primate animal. Further involved are a pharmaceutical composition comprising the antigen binding protein, and an application of the antigen binding protein and/or the pharmaceutical composition in the prevention and/or treatment of a tumor or a cancer.

Abstract: A compound containing a benzene ring as shown in formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, an isotopic compound thereof, a crystal form thereof, a nitrogen oxide thereof, and a solvate thereof or a solvate of the pharmaceutically acceptable salt thereof are provided. The compound has high P2X4 antagonistic activity, good selectivity, low toxicity and good metabolic stability.

Abstract: Disclosed is a fused ring compound and an application thereof. Disclosed is a fused ring compound represented by formula I, a pharmaceutically acceptable salt, a stereoisomer, a tautomer, an isotope compound, a crystal form, a nitrogen oxide, a solvate, or a solvate of the pharmaceutically acceptable salt thereof. The fused ring compound of the present invention has high P2X4 antagonistic activity, excellent selectivity, low toxicity and excellent metabolic stability.

Abstract: A supplier information updating system in communication with an order system and a stock system of a manufacturer includes a supplier database operable to store information regarding suppliers of the manufacturer and a part database operable to store information regarding various parts provided by the suppliers. The system obtains inquiry results regarding the parts and corresponding suppliers, and updates the information regarding the parts and corresponding suppliers according to the inquiry results. The system further generates an unqualified part list including the unqualified parts and corresponding suppliers according to the updated information regarding the parts and corresponding suppliers, marks one or more part orders including the newly added unqualified parts and corresponding suppliers, and provides the marked part orders to the order system of the manufacturer.