Abstract: Provided is a triazolopyridazine derivative, a preparation method therefor, a pharmaceutical composition thereof, and an application thereof. The triazolopyridazine derivative is represented by formula I. The triazolopyridazine derivative has excellent inverse agonistic activity, thermodynamic solubility, bioavailability, and pharmacokinetic properties; thus having promising application prospects.

Abstract: The present application discloses a photovoltaic module. In an implementation, the photovoltaic module includes: a junction box, including a bonding pad; and a busbar, one end of the busbar is attached to a surface of the bonding pad and soldered to the bonding pad through at least one soldering joint, where the soldering joint penetrates through one end of the busbar and extends into the bonding pad, the extension depth of the soldering joint in the bonding pad is x, and the length of the soldering joint is y, where y is greater than or equal to ?5x+4.5.

Abstract: The present disclosure discloses anti-BCL6 nanobody, fusion protein comprising the same and use thereof, which belong to the field of biotechnology. In the present disclosure, artificial intelligence technology is employed to design nanobodies specifically targeting BCL6. The nanobodies exhibit favorable specificity and high affinity, and can efficiently bind to BCL6 antigen. Furthermore, rational design of the nanobodies is performed via artificial intelligence to obtain nanobody mutants with higher affinity. Furthermore, fusion proteins are obtained by fusing the nanobodies or nanobody mutants with high affinity and favorable specificity with an RBCC domain or a mutant thereof. The fusion proteins can specifically bind to the target protein via their nanobody domains, activate the protein degradation pathway, and achieve targeted degradation of BCL6 protein, thereby upregulating the intracellular expression of the tumor suppressor gene p53 and cyclin p21, which has great clinical application value.

Abstract: The present disclosure provides a binder that specifically targets the PCNA protein, a fusion protein comprising the same, and uses thereof, which belong to the field of biotechnology. In the present disclosure, artificial intelligence technology is employed to design binders that specifically target PCNA. The resulting binders exhibit good specificity and high affinity, and are capable of efficiently binding to the PCNA antigen. Further, fusion proteins are prepared by fusing the aforementioned binders to an RBCC domain or a mutant thereof, or by directly fusing the aforementioned binders to an Fc fragment.

Abstract: The present disclosure provides anti-PCNA nanobodies, fusion proteins comprising the same, and uses thereof, which belong to the field of biotechnology. In the present disclosure, artificial intelligence technology is employed to design nanobodies that specifically target PCNA. The nanobodies exhibit favorable specificity and high affinity, and are capable of efficiently binding to the PCNA antigen. Further, rational design of the nanobodies via artificial intelligence technology yields nanobody mutants with higher affinity. Moreover, fusion proteins are prepared by fusing the aforementioned nanobodies or nanobody mutants with an RBCC domain or its mutant.

Abstract: In some embodiments, a method for semiconductor processing preclean includes removing an oxide layer from a substrate using anhydrous hydrogen fluoride in combination with water vapor. A system for the preclean may be configured to separate the anhydrous hydrogen fluoride and the water vapor until they are delivered to a common volume near the substrate. Corrosion within components of the system may be limited by purification of anhydrous hydrogen fluoride, passivation of components, changing component materials, and heating components. Passivation may be achieved by filling a gas delivery component with anhydrous hydrogen fluoride and allowing the anhydrous hydrogen fluoride to remain in the gas delivery component to form a passivation layer. Consistent water vapor delivery may be achieved in part by heating components using heaters.

Abstract: A method for compiling a computation graph for execution on a reconfigurable processor comprising one or more configurable compute units. The method may include compiling the computation graph having one or more symbolic dimensions with values unresolved at compile time, where the compiling includes tracking symbolic expressions as functions of the symbolic dimensions. The method may further include producing a compiled configuration for the reconfigurable processor, where the compiled configuration includes one or more configuration parameters derived from the tracked symbolic expressions, the configuration parameters being settable at runtime based on runtime values of the symbolic dimensions.

Abstract: An acquisition apparatus, an acquisition system, and a control method for multi-source aerial remote sensing data are applied to the field of aerial survey and remote sensing technology. The acquisition apparatus for multi-source aerial remote sensing data includes: a flight platform and onboard equipment arranged on the flight platform; wherein the onboard equipment includes: a multi-sensor ultra-compact integrated device, an onboard integrated synchronization control device, and a GNSS receiving antenna; the multi-sensor ultra-compact integrated device is connected to the onboard integrated synchronization control device via a cable, and the GNSS receiving antenna is arranged on an upper end face of the flight platform; the multi-sensor ultra-compact integrated device is configured to acquire multi-source remote sensing data; and the onboard integrated synchronization control device is configured to control the operation of the multi-sensor ultra-compact integrated device.

Abstract: Provided is a smelting and continuous casting method for high Cr—Si alloyed hot-formed steel. During a smelting process, in response to the problems that this steel grade needs large addition quantity of alloys containing silicon, manganese and chromium, precise composition control on coating-free hot-formed steel alloys is achieved through a reasonable match of two manners of alloy addition into a ladle at a converter steelmaking stage and alloy addition at LF refining stage. During a continuous casting process, in response to the problems that air gaps are easy to form in this steel grade and a billet shell is not uniform, low-basicity mold fluxes with uniform heat transfer and good lubrication are provided for the continuous casting process of the high Cr—Si hot-formed steel.

Abstract: An uplink transmission method and apparatus, a terminal and a storage medium are provided. The method includes: a first terminal determining a first slot; the first slot representing a slot available for a transmission or repetition transmissions of a PUSCH; and the number of symbols available for the first slot being greater than or equal to the number of symbols indicated for each transmission or repetition transmissions.

Abstract: A method comprises a compiler analyzing a graph to determine a pipeline of operators based on a shared dimension of input and output tensors among the operators. The operators are included in the graph and the graph corresponds to a dataflow application. The compiler determines a tiling decision associated with the pipeline and a tiling cost associated with the tiling decision. The tiling decision can comprise a tile shape to slice tensors of operators of the pipeline. Based on the tiling cost, the compiler determines that the tiling decision improves an optimization objective and includes the pipeline and tiling decision in mapping decisions associated with executing the application on a computing system. The compiler can apply a tiling cost model to determine the tiling costs. A computer program product and a computing system can implement the method.

Abstract: A method and a system for detecting railway foreign object intrusion, and a device and a medium can include acquiring a first key frame of railway image of a current scenario as a template image, and an Nth frame of railway image as a to-be-detected image; inputting the template image and the to-be-detected image of the current scenario into a foreign object intrusion prediction model to obtain a foreign object feature map of the current scenario, so as to determine whether there is a different target between the to-be-detected image and the template image of the current scenario; and filtering, by using a moving object filter model, a moving object from the different target of the to-be-detected image of the current scenario in response to existing different target, to obtain a true foreign object in the to-be-detected image of the current scenario.

Abstract: Provided are systems, methods, and computer program products for dynamic peer group analysis for systematic changes in large scale data. Data associated with a plurality of entities is received and a relational graph is generated based on the data. A target entity is selected and a peer group for the target entity is determined based on the relational graph. An average and a standard deviation of the risk scores of the peer group are calculated and used to determine whether a systematic change in the behavior of the peer group has occurred. Whether a change in behavior of the target entity is a false anomaly or a true anomaly is determined based on whether a systematic change in the behavior of the peer group has occurred. An action is performed based on whether the change in behavior of the target entity is a false anomaly or a true anomaly.

Abstract: At least one processor determines bounding boxes in an image using a neural network. At least one processor extracts an initial bounding box for an object in the image. At least one processor selects a cluster center of the bounding boxes and circumscribes a cluster box around the cluster center. At least one processor rotates the initial bounding box and contents of the initial bounding box according to a rotation angle determined based on the cluster box. At least one processor detects the object in the rotated initial bounding box using a trained machine learning model.

Abstract: An electronic device may include wireless circuitry with a transmission line path coupled between a transceiver and antenna. An amplifier may be disposed on the transmission line path. The amplifier may have a reconfigurable matching network at its output. The network may have coupled lines such as transmission line segments or transformer coils. The coupled lines may couple an input port of the network to a load port and a control port of the network. The load port may be coupled to the antenna. The control port may be coupled to an adjustable termination. The control port may receive a control signal that configures the adjustable termination to exhibit an impedance selected based on a VSWR of the antenna. The impedance of the adjustable termination may be tuned so the amplifier sees a consistent load impedance at the load port even as the VSWR of the antenna changes over time.

Abstract: A channel state information reporting method includes: receiving configuration information regarding channel state information (CSI) transmitted by a network device, determining a first type of CSI and a second type of CSI based on the configuration information; and reporting the first type of CSI and the second type of CSI to the network device.

Abstract: Aspects of the present disclosure involve a system comprising a computer-readable storage medium storing a program and method for clinical trial emulation using multi-agent learning.

Abstract: A liquid crystal composition includes at least one liquid crystal compound of a general formula (I), at least one elastic constant regulator of a general formula (II), and at least one chiral compound. A light modulating device with the liquid crustal composition has at least two stable states in the absence of applied voltage, at least one state allowing incident light to pass through substantially (transparent state), and at least one state scattering incident light substantially (foggy state). The transparent state and the foggy state may be switched by means of an external electric field. The transparent state is clear and highly transmissive, while the foggy state provides privacy protection. By introducing a bimesogenic compound and adjusting the helical pitch of the liquid crystal composition system to P?3.5 ?m, the uniformity of the planar arrangement of the liquid crystal composition molecules is improved and texture defects are reduced.

Abstract: A grass trimmer includes a trimming head, a driving device for driving the trimming head to rotate so as to cut vegetation and an operating device for a user to operate so as to control the driving device. The trimming head includes a spool and a line holding element, the spool is used to wind a trimming line, and the line holding element is formed with a line holding structure. The driving device includes a motor. The grass trimmer has an auto-winding mode. In the auto-winding mode, the motor drives at least one of the spool and the line holding element to make the spool and the line holding element rotate relatively so that the trimming line is wound on the spool automatically.

Abstract: This disclosure relates generally to a method, device, and system for mapping, and transmission of UCI in a wireless network. One method performed by a wireless device is disclosed. The method may include: receiving, from a network node, a UCI mapping information associated with a Physical Uplink Control Channel (PUCCH) using a first Radio Access Technology (RAT), the UCI mapping information indicating RATs of UCIs assigned to be transmitted in the PUCCH, wherein at least one of the RATs is a second RAT different from the first RAT; and transmitting a first set of UCIs in the PUCCH based on the UCI mapping information, wherein a RAT of at least one UCI in the first set of UCIs is different from the first RAT.