Abstract: An EP300/CBP inhibitor, specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the activity of EP300/CBP; in addition, the compound has an excellent inhibitory effect on various tumor cells including prostate cancer cells, leukemia cells, breast cancer cells and multiple myeloma cells. The compound has broad application prospects in the preparation of an EP300/CBP inhibitor, and drugs for preventing and/or treating tumors, myeloid hematopoietic stem/progenitor cells malignant disease, and regulating regulatory T cells.

Abstract: Disclosed are an airborne electromagnetic wave device, and an anti-interference system, method and apparatus. The anti-interference method comprises: detecting an interference source, and obtaining a working frequency and a bandwidth of the interference source; calculating an interfered bandwidth range at least on the basis of the working frequency and bandwidth of the interference source; and controlling an electrically tunable filter provided in a transmission channel of the airborne electromagnetic wave device to filter signals within the interfered bandwidth range.

Abstract: An airborne short message communication method, apparatus, device and system, and a readable storage medium. In the technical solution provided in the present invention, the method comprises: an airborne short message communication device acquiring a message control command; by means of the message control command, selecting a target message type from among selectable message types and determining a sending frequency; generating a target message corresponding to the target message type; and sending the target message according to the determined sending frequency. According to the technical solution provided in the present invention, the problems of delayed communication and large consumption caused by an unchanging message type and message sending frequency can be avoided, and in an emergency state, the message type and the message sending frequency can be changed, such that an important message can be sent in a timely manner.

Abstract: A laser soldering system includes a laser source module, a polarization adjusting assembly, a temperature sensor, and a controller. The laser source module is configured to emit a laser beam. The polarization adjusting assembly includes a plurality of polarization elements and at least one stepping motor. The polarization elements are configured to split the laser beam into a Gaussian beam and a ring-shaped beam. The Gaussian beam illuminates the first element, and the ring-shaped beam is illuminates the second element. The stepping motor is configured to adjust a size of the ring-shaped beam. The temperature sensor is configured to monitor temperatures of the first element and a temperature of the second element. The controller is electrically connected to the temperature sensor, the laser source module, and the polarization adjusting assembly.

Abstract: The present disclosure relates to an array substrate, a display device, and a method for fabricating an array substrate. The array substrate includes a pixel defining layer on the dielectric layer, the pixel defining layer defining a plurality of pixel regions of the array substrate, and light emitting device on the dielectric layer and in the plurality of pixel regions. The device includes a first electrode, a light emitting layer, and a second electrode sequentially disposed from bottom to top. At least one of the plurality of pixel regions has a non-light emitting region adjacent to the pixel defining layer. The dielectric layer in the non-light emitting region has a groove. The array substrate further includes a light shielding portion located in the non-light emitting region and extending into the groove.

Abstract: Provided is an array light source. The array light source includes light-emitting modules, a wavelength conversion apparatus configured to convert excitation light into excited light, a control apparatus configured to transmit a light modulation signal, and a light modulation apparatus configured to modulate the excited light based on the light modulation signal, emit the modulated light, and form a modulated image. Each light-emitting module is configured to emit the excitation light. The light-emitting modules include edge light emitting modules distributed along an edge of the array light source and center light-emitting modules surrounded by the edge light-emitting modules. A maximum luminous intensity of the edge light-emitting modules is greater than that of the center light-emitting modules.

Abstract: Various embodiments include a method for deploying field device into an Internet of Things (IoT). The method may include: acquiring information from a field device using an edge device; transmitting the acquired information to a cloud platform; wherein the information comprises data and an industrial IoT model; converting the industrial IoT model into a graph; performing similarity analysis based on the graph; classifying the industrial IoT model based on the similarity analysis; generating a first industrial IoT model comprising a type or an example; performing data mapping on the first industrial IoT model; and operating the field device as part of the IoT.

Abstract: The present invention provides an airborne BeiDou system and method for application thereof, the airborne BeiDou system comprising: an airborne communication navigation monitoring system which integrates a BeiDou application software module of a BeiDou navigation communication sub-system and a BeiDou protocol stack software module; a BeiDou transceiver connected to said airborne communication navigation monitoring system; a BeiDou server connected to said BeiDou transceiver.

Abstract: This disclosure relates to methods of functionalizing a nanoparticle, e.g., for conjugation to a targeting ligand and/or payload moiety, such as for the production of a nanoparticle drug conjugate (NDC).

Abstract: Embodiments provide enhanced performance diagnosis in a network computing environment. In response to an occurrence of a performance issue for a node while under operating conditions, common logs for applications on the node are analyzed. The applications are respectively registered in advance for diagnosis services. The applications each register rules in advance for the diagnosis services. At a time of the performance issue, debug programs are automatically issued to generate debug level logs respectively for the applications. Debug level logs are analyzed according to the rules to determine a root cause of the performance issue. A potential solution to the root cause of the performance issue is determined using the rules, without having to recreate the operating conditions occurring during the performance issue. The potential solution to rectify the root cause of the performance issue is executed without having to recreate the operating conditions occurring during the performance issue.

Abstract: Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites. These are then isolated and characterized. Employing the disclosed approach activated production of cryptic glycopeptides from an actinomycete bacterium. The molecules that result, the keratinimicins and keratinicyclins, are metabolites with important structural features. At least two of these, keratinimicins B and C, are highly bioactive against several pathogenic strains. This approach will allow for rapid activation and identification of cryptic metabolites from diverse microorganisms in the future.

Abstract: A system of image processing based emotion recognition is disclosed. The system principally comprises a camera and a main processor. Particularly, there a plurality of function units provided in the main processor, including: face detection unit, feature processing module, feature combination unit, conversion module, facial action judging unit, and emotion recognition unit. According to the present invention, the emotion recognition unit is configured to utilize a facial emotion recognition (FER) model to evaluate or distinguish an emotion state of a user based on at least one facial action, at least one emotional dimension, and a plurality of emotional scores. As a result, the accuracy of the emotion recognition conducted by the emotion recognition unit is significantly enhanced because basis of the emotion recognition comprises basic emotions, emotional dimension(s) and the user's facial action.

Abstract: Substituted piperidines as BTK inhibitors, a preparation method thereof and a pharmaceutical application thereof. The substituted piperidines is a compound represented by a general formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, and the substituted piperidines is used to treat BTK-related diseases such as tumors or autoimmune system diseases.

Abstract: Disclosed is a device for evaluating damage of fracturing fluid to reservoir and operation method thereof, the device includes a liquid storage tank, a suction tube, a chromatography device, a bracket, a receiving container and a height adjuster; the disclosure has the following beneficial effects: since different liquids pass through the porous medium at different time and speed and the silica gel particles will not expand when immersed in the liquid, a porous structure is formed by placing silica gel particles of different sizes to simulate the pore-throat structure of unconventional oil and gas reservoirs, hence removing the influence of fracturing fluid on the hydration and expansion damage of the reservoir matrix, by testing the time and flow rate of different fracturing fluids flowing through the silica gel pores, the degree of damage caused by fracturing fluids to unconventional oil and gas reservoirs is evaluated.

Abstract: A method for cleaning an air conditioner comprises: in response to a cleaning instruction, controlling frosting on the surface of a target heat exchanger; after a frosting completion condition is met, controlling defrosting of the frost on the target heat exchanger; and after a defrosting completion condition is met, reducing the surface temperature of the target heat exchanger to a sterilization temperature, and carrying out quick cooling sterilization, wherein the temperature difference between the sterilization temperature and the defrosting temperature during defrosting meets a set temperature change sterilization condition. By means of a frosting-defrosting process, dirt such as dust on the heat exchanger may be effectively stripped and deep bacteria may be exposed, and then the quick cooling sterilization process may kill the bacteria by utilizing the sharp temperature change during switching from the defrosting process to the quick cooling process. Also disclosed is the air conditioner.

Abstract: An electrochemical device, including an electrode and an electrolyte. The electrolyte including a dinitrile compound, a trinitrile compound, and propyl propionate. Based on the total weight of the electrolyte, the weight percentage of the dinitrile compound is X, the weight percentage of the trinitrile compound is Y, and the weight percentage of the propyl propionate is Z. Wherein about 2 wt %?(X+Y)?about 11 wt %, about 0.1?(X/Y)?about 8. The electrode including a coating, which including a single-sided sub-coating and a double-sided coating, the electrode with the single-sided sub-coating has an electrode compaction density D1, and the electrode with the double-sided coating has an electrode compaction density D2, where about 0.8?D1/D2?about 1.2. The electrolyte and D1/D2 of the electrodes has a significant effect on the cycle performance of the electrochemical device.

Abstract: An electrolyte including a dinitrile compound, a trinitrile compound, and propyl propionate. Based on the total weight of the electrolyte, the weight percentage of the dinitrile compound is X, the weight percentage of the trinitrile compound is Y, and the weight percentage of the propyl propionate is Z; where about 2 wt %?(X+Y)?about 11 wt %, about 0.1?(X/Y)?about 8, and about 0.01?(Y/Z)?about 0.3. The dinitrile compound comprises a compound of Formula (5): N—R2—(O—R3)n—O—R4—CN (5). The electrolyte is capable of effectively inhibiting the increase in DC internal resistance of an electrochemical device so that the electrochemical device has excellent cycle and storage performance.

Abstract: An electrochemical apparatus includes an electrode plate including a current collector, a first coating layer, and a second coating layer. The first coating layer is provided between the current collector and the second coating layer. The second coating layer includes a first active material. R2*d/D<R1, wherein R1 refers to a resistance of the first coating layer, R2 refers to a resistance of the second coating layer, d refers to a thickness of the first coating layer, D refers to a thickness of the second coating layer, R2 and R1 are measured in ohms, and D and d are measured in microns.

Abstract: The present invention discloses a preparation method for a metal material, including: horizontally placing a to-be-prepared metal material between wavy surfaces of a female die and a male die; connecting a press machine with the male die; pressing the metal material through the male die, so that the metal material makes complete contact with the male die and the female die; ejecting the pressed metal material; horizontally overturning the metal material, and then placing the metal material between the wavy surfaces of the female die and the male die; repeatedly performing the pressing and overturning processes until accumulated strain of the metal material meets a requirement; and taking out the metal material after the deformed metal material is flattened by a plane die. According to the present invention, a large-size nano grained material can be manufactured.

Abstract: A method for anti-counterfeit inspection of a QR code of an agricultural product based on a watermark library. The method includes establishing a watermark-containing QR code library; tracing a QR code watermark image; and verifying the QR code watermark image. Watermark-containing QR codes are generated by a QR code generation module and a watermark library, and the watermark-containing QR codes are constructed as the watermark-containing QR code library. The watermark-containing QR code library is used to verify the QR code watermark image, and the QR code watermark image is obtained by tracing the watermark-containing QR codes. In the method for anti-counterfeit inspection of a QR code of an agricultural product based on a watermark library, an image watermark library is designed, so that the embedding of a watermark is no longer single.