Abstract: A workpiece comprises a substrate. A texture layer is provided on the surface of one side of the substrate, and comprises a plurality of first-level regions; each first-level region comprises a plurality of structural units; the plurality of structural units comprise at least a first structural unit and a second structural unit connected to each other; the first structural unit and the second structural unit each internally comprise a plurality of sequentially arranged first texture stripes and a plurality of sequentially arranged second texture stripes; two ends of at least some first texture stripes both fall on the contour of the first structural unit; two ends of at least some second texture stripes both fall on the contour of the second structural unit; and the ends of the at least some first texture stripes are in contact with the ends of the at least some second texture stripes.

Abstract: A texture structure, a cover plate, a mobile terminal, and a preparation method for the cover plate are disclosed. The texture structure includes a substrate, and a plurality of groups of gratings provided on one side of the substrate. The plurality of groups of gratings are arranged on the surface of the substrate in a crisscross pattern. Each group of gratings includes a plurality of grating units arranged side by side and extending in the same direction, and each grating unit is configured to have a grating surface inclined to the substrate.

Abstract: A method and a system of molecular typing and subtyping classifier for immune-related diseases are provided. The method includes: conducting molecular typing via a clustering algorithm in a training set to obtain a plurality of subtypes stably appearing in the training set and a marker gene for each subtype; conducting enrichment analysis on marker genes for the plurality of subtypes, conducting immune cell infiltration evaluation on the plurality of subtypes, and dividing the plurality of subtypes into a plurality of subtype classes according to results of the analysis and the evaluation; comparing treatment response rates of different subtype classes through a comparison set to determine a subtype class to be identified; constructing a support vector machine model with feature genes screened and an optimal parameter combination; and determining whether immune-related disease data to be classified is the subtype class to be identified.

Abstract: The present invention provides a general sequence of chimeric antigen receptor (CAR) and an application thereof, The hinge domain in the general sequence includes hinge domain V-5, hinge domain V-4-5, hinge domain V-3-4-5, hinge domain V-2-3-4-5 or hinge domain V-1-2-3-4-5. The CAR constructed by using the general sequence of the chimeric antigen receptor of the present invention can significantly improve the antigen-specific immune response of CAR-T cells, enhance the sensitivity of CAR-T cells and resist exhaustion, so as to enhance the therapeutic effect of CAR-T cells and enhance the therapeutic effect of anti-tumor agents. At the same time, the CAR containing the general sequence of the present invention is suitable for transfection of immune cells such as T cells and NK cells, and can be broadly applied to tumor therapy.

Abstract: The present invention provides a general sequence of chimeric antigen receptor (CAR) and an application thereof, The hinge domain in the general sequence includes hinge domain V-5, hinge domain V-4-5, hinge domain V-3-4-5, hinge domain V-2-3-4-5 or hinge domain V-1-2-3-4-5. The CAR constructed by using the general sequence of the chimeric antigen receptor of the present invention can significantly improve the antigen-specific immune response of CAR-T cells, enhance the sensitivity of CAR-T cells and resist exhaustion, so as to enhance the therapeutic effect of CAR-T cells and enhance the therapeutic effect of anti-tumor agents. At the same time, the CAR containing the general sequence of the present invention is suitable for transfection of immune cells such as T cells and NK cells, and can be broadly applied to tumor therapy.