Abstract: The disclosure provides new therapeutic uses for certain fused ring pyrimidine compounds, in particular for treating patients having a cancer which expresses elevated fibroblast growth factor receptor oncogene partner 2 (FGFR1OP2) and/or elevated FGFR1, or expresses a FGFR1-FGFR1OP2 fusion protein, and for treating patients who are being treated with an immune checkpoint inhibitor.

Abstract: The invention provides methods for treating a cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a small molecule inhibitor of the PD-1/PD-L1 interaction or a pharmaceutically acceptable salt or prodrug thereof in combination with a therapeutically effective amount of an anti-PD-1 antibody, wherein the small molecule inhibitor of the PD-1/PD-L1 interaction is not a protein.

Abstract: Provided herein are methods for treating a cancer in a subject having a tumor with interstitial fluid pressure (IFP) of at least 10 mmHg, comprising administering to the subject a therapeutically effective amount of a compound or a pharmaceutically acceptable salt or prodrug thereof, which is an inhibitor of the interaction between the PD-1 receptor and its ligand PD-L1 and which is not a protein, alone, or in combination with other agents, e.g., in combination with the use of anti-PD-1/PD-L1 antibodies, in combination with an inhibitor of the CTLA-4/B7 interaction, or in combination with an inhibitor binding to VEFG.

Abstract: A small molecule inhibitor of PD-1/PD-L1, a pharmaceutical composition thereof with a PD-L1 antibody, and an application of the same. The small molecule inhibitor of PD-1/PD-L1 is aromatic ethylene or aromatic ethylene derivative represented by general formula (I) and can be used to treat cancer.