Patents by Inventor Felice LIGHTSTONE

Felice LIGHTSTONE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITION OF KRAS
    Publication number: 20260125386
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a Q61H, G12D, G12V, G12C, G12S, G12A, G12R, or G13D mutation or wild-type KRAS) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: January 5, 2026
    Publication date: May 7, 2026
    Inventors: Zuhui Zhang, Bin Wang, Eli Wallace, Rui Xu, Paul Wehn, Yue Yang, Felice Lightstone, Jun Pei, Anna Elzbieta Maciag, David Michael Turner, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Christopher John Brassard, Tao Liao
  • COMPOSITIONS AND METHODS FOR INHIBITION OF KRAS
    Publication number: 20260042764
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e g., inhibiting) KRAS (e.g., KRAS having a Q61H, G12D, G12V, G12C, G12S, G12A, G12R, or G13D mutation or wild-type KRAS) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: August 4, 2023
    Publication date: February 12, 2026
    Inventors: Zuhui Zhang, Bin Wang, Eli Wallace, Rui Xu, Paul Wehn, Yue Yang, Felice Lightstone, Jun Pei, Anna Elzbieta Maciag, David Michael Turner, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Christopher John Brassard, Tao Liao
  • COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
    Publication number: 20260035376
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: August 4, 2023
    Publication date: February 5, 2026
    Inventors: Zuhui Zhang, Bin Wang, Rui Xu, Eli Wallace, Yue Yang, Felice Lightstone, Jun Pei, Anna Elzbieta Maciag, David Michael Turner, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Christopher John Brassard, Tao Liao
  • Compositions and methods for inhibition of RAS
    Patent number: 12528818
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Grant
    Filed: May 1, 2025
    Date of Patent: January 20, 2026
    Assignees: Leidos Biomedical Research, Inc., Lawrence Livermore National Security, LLC, TheRas, Inc.
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Zuhui Zhang, David Michael Turner, Anna Elzbieta Maciag, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Tao Liao, Christopher John Brassard, Yue Yang, Paola Bisignano, Felice Lightstone
  • COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
    Publication number: 20250270225
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: May 1, 2025
    Publication date: August 28, 2025
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Zuhui Zhang, David Michael Turner, Anna Elzbieta Maciag, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Tao Liao, Christopher John Brassard, Yue Yang, Paola Bisignano, Felice Lightstone
  • COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
    Publication number: 20250270206
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: May 19, 2023
    Publication date: August 28, 2025
    Inventors: Eli Wallace, Bin Wang, Rui Xu, Zuhui Zhang, Yue Yang, Felice Lightstone, Anna Elzbieta Maciag, David Michael Turner, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Christopher John Brassard, Tao Liao
  • COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS
    Publication number: 20250230138
    Abstract: Provided herein are compounds and compositions thereof that may be capable of disrupting, interrupting, and/or preventing an interaction between a small GTPase protein and a PI3K protein (e.g., PI3Ka). The present disclosure also provides methods of treating cancers and other indications with such compounds or compositions thereof.
    Type: Application
    Filed: February 7, 2023
    Publication date: July 17, 2025
    Inventors: Rui Xu, Bin Wang, Eli Wallace, Paul Wehn, Pedro J. Beltran, James Stice, Kerstin Sinkevicius, Yue Yang, Paola Bisignano, Felice Lightstone, Dhirendra Kumar Simanshu, David Michael Turner, Daniel J. Czyzyk, Swapnil Singh, Jayasudhan Reddy Yerabolu, Francis Patrick McCormick
  • COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
    Publication number: 20250188085
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: January 5, 2023
    Publication date: June 12, 2025
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Zuhui Zhang, Anna Elzbieta Maciag, David Michael Turner, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Felice Lightstone, Yue Yang
  • COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
    Publication number: 20250084079
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D or G12V mutation or wild-type KRAS) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: January 5, 2023
    Publication date: March 13, 2025
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Zuhui Zhang, Felice Lightstone, Yue Yang, David Michael Turner, Anna Elzbieta Maciag, Dhirendra Kumar Simanshu, Albert Hay Wah Chan
  • COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
    Publication number: 20240300964
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: July 22, 2022
    Publication date: September 12, 2024
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Zuhui Zhang, David Michael Turner, Anna Elzbieta Maciag, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Tao Liao, Christopher John Brassard, Yue Yang, Paola Bisignano, Felice Lightstone
  • COMPOSITIONS AND METHODS FOR INHIBITING KRAS
    Publication number: 20240246954
    Abstract: Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: February 15, 2022
    Publication date: July 25, 2024
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Felice Lightstone, Yue Yang, Paola Bisignano, Anna Elzbieta Maciag, David Michael Turner, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Zuhui Zhang, Christopher John Brassard, Tao Liao
  • Compounds for reactivation of acetylcholinesterase and related compositions methods and systems
    Patent number: 10590498
    Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: March 17, 2020
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos A. Valdez, Nicholas A. Be, Brian Bennion, Tim Carpenter, Heather Ann Enright, Felice Lightstone, Mike Malfatti, Margaret Windy McNerney, Tuan H. Nguyen
  • COMPOUNDS FOR REACTIVATION OF ACETYLCHOLINESTERASE AND RELATED COMPOSITIONS METHODS AND SYSTEMS
    Publication number: 20170335415
    Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
    Type: Application
    Filed: May 15, 2017
    Publication date: November 23, 2017
    Inventors: Carlos A. VALDEZ, Nicholas A. BE, Brian BENNION, Tim CARPENTER, Heather Ann ENRIGHT, Felice LIGHTSTONE, Mike MALFATTI, Margaret Windy MCNERNEY, Tuan H. NGUYEN