Patents by Inventor Felice LIGHTSTONE

Felice LIGHTSTONE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
    Publication number: 20250084079
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D or G12V mutation or wild-type KRAS) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: January 5, 2023
    Publication date: March 13, 2025
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Zuhui Zhang, Felice Lightstone, Yue Yang, David Michael Turner, Anna Elzbieta Maciag, Dhirendra Kumar Simanshu, Albert Hay Wah Chan
  • COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
    Publication number: 20240300964
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: July 22, 2022
    Publication date: September 12, 2024
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Zuhui Zhang, David Michael Turner, Anna Elzbieta Maciag, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Tao Liao, Christopher John Brassard, Yue Yang, Paola Bisignano, Felice Lightstone
  • COMPOSITIONS AND METHODS FOR INHIBITING KRAS
    Publication number: 20240246954
    Abstract: Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Application
    Filed: February 15, 2022
    Publication date: July 25, 2024
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Felice Lightstone, Yue Yang, Paola Bisignano, Anna Elzbieta Maciag, David Michael Turner, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Zuhui Zhang, Christopher John Brassard, Tao Liao
  • Compounds for reactivation of acetylcholinesterase and related compositions methods and systems
    Patent number: 10590498
    Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: March 17, 2020
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos A. Valdez, Nicholas A. Be, Brian Bennion, Tim Carpenter, Heather Ann Enright, Felice Lightstone, Mike Malfatti, Margaret Windy McNerney, Tuan H. Nguyen
  • COMPOUNDS FOR REACTIVATION OF ACETYLCHOLINESTERASE AND RELATED COMPOSITIONS METHODS AND SYSTEMS
    Publication number: 20170335415
    Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
    Type: Application
    Filed: May 15, 2017
    Publication date: November 23, 2017
    Inventors: Carlos A. VALDEZ, Nicholas A. BE, Brian BENNION, Tim CARPENTER, Heather Ann ENRIGHT, Felice LIGHTSTONE, Mike MALFATTI, Margaret Windy MCNERNEY, Tuan H. NGUYEN