Patents by Inventor Felicia Pagliuca

Felicia Pagliuca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL THERAPY FOR DIABETES
    Publication number: 20250057880
    Abstract: Disclosed herein are methods of treating a subject having diabetes with a population of cells expressing ISL1 and one or more immunosuppressive reagents, such as an anti-thymocyte globulin binding moiety.
    Type: Application
    Filed: July 26, 2024
    Publication date: February 20, 2025
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Bote Bruinsma, Andrea Vergani, Felicia Pagliuca, George Harb, Jason Gaglia
  • CELL THERAPY FOR DIABETES
    Publication number: 20230332107
    Abstract: Disclosed herein are compositions, kits, and methods related to cell therapy for a disease characterized by high blood glucose levels over a long period of time, such as diabetes. In some aspects, the methods provided herein relate to administration of non-native pancreatic cells to subject with a disease characterized by high blood glucose levels over a long period of time, such as diabetes. In some aspects, the disclosure provides pharmaceutical compositions including non-native cells.
    Type: Application
    Filed: January 31, 2023
    Publication date: October 19, 2023
    Inventors: Felicia PAGLIUCA, George HARB, Jason GAGLIA, Andrea VERGANI, Christopher THANOS
  • METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS
    Publication number: 20230146780
    Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.
    Type: Application
    Filed: November 11, 2022
    Publication date: May 11, 2023
    Inventors: Felicia PAGLIUCA, George HARB, Mads GURTLER, Austin THIEL, Jihad YASIN, Evrett THOMPSON
  • METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS
    Publication number: 20230137854
    Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.
    Type: Application
    Filed: November 11, 2022
    Publication date: May 4, 2023
    Inventors: Felicia PAGLIUCA, George HARB, Mads GURTLER, Austin THIEL, Jihad YASIN, Evrett THOMPSON
  • METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS
    Publication number: 20210198632
    Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.
    Type: Application
    Filed: September 2, 2020
    Publication date: July 1, 2021
    Inventors: Felicia Pagliuca, George Harb, Mads Gurtler, Jason Gaglia, Yeh-Chuin Poh, Lillian Ye, Austin Thiel, Jihad Yasin, Evrett Thompson