Abstract: The present invention provides phase separation sensors capable of targeting or associating with one or more biomolecular condensate or membraneless compartment in cells. The phase separation sensors comprise at least two domains wherein a first domain comprises one or more accessory protein or molecule and a second domain comprises an artificial client protein or intrinsically disordered sequence. The artificial client protein possesses intrinsic disorder and is capable of engaging in ultra-weak phase separation-specific interactions with one or more component protein or molecule in a biomolecular condensate. Methods and applications utilizing the sensors are provided including targeting, detecting, visualizing, manipulating, monitoring a biomolecular condensate and delivering one or more functional protein, label, drug or agent to a biomolecular condensate.

Abstract: The presently disclosed subject matter relates to modular peptide-substrate protease assays, in particular low cost and reliable methodology for measurement of protease and other enzyme activity that may be detected by optical turbidimetry or visual observation. The presently disclosed subject matter also relates to methods of using the disclosed assays within methods of detecting and monitoring diseases, methods of drug discovery, as well as in detection devices and systems.

Abstract: A flow regulation device for liquid having a body with an inlet opening, an outlet opening, and a cavity between the two openings. An actuating means is disposed in the cavity for stopping and starting the flow of liquid through said device. The actuating means is configured to be moved in a first direction to start the flow of liquid through said device and in the first direction to stop the flow of liquid through said device. The actuating may comprise an upper button and a lower cam.

Abstract: A water flow regulation device having a body with an inlet opening and at least one outlet opening. Each outlet opening is associated with an actuating device that controls the flow of water out of the associated outlet opening. A pedal or cap may be depressed by a user in order to selectively control the water flow to one of the outlets.

Abstract: An online system provides advertisers with opportunities to bid on presentation of advertisements to a user. Advertisers may bid in real-time on advertisement presentation if the online system determines the expected revenue to the online system from real-time bids is above a threshold value. The expected revenue may be determined based on a probability distribution bids previously placed by advertisers for presenting advertisements to the user or to users with similar characteristics as the user.

Abstract: An entity having a brand page maintained by a social networking system defines a sequence of content items associated with a brand page is determined. Different content items in the sequence include different information that is dependent on interaction between a user and the sequence. For example, content items in the sequence provide increasingly more detailed or complex information when progressing from the first content item to the last content item in the sequence. When a viewing user of a social networking system interacts with the brand page, prior interactions with the sequence by the viewing user are used to classify the viewing user and to select a content item from the sequence that is communicated to the viewing user.

Abstract: An online system facilitates auctions for advertising presentation opportunities by identifying users associated with the presentation opportunities. The online system stores mappings between user identifiers and a plurality of partner identifiers used by advertisers to identify browsers. Partner identifiers are received from an advertising exchange and used to identify a user identifier corresponding to the received partner identifier. Using the identified user identifier, the online system identifies an alternative partner identifier associated with the user identifier and sends the alternative user identifier to an advertiser for use in selecting and bidding on advertisements. The online system returns the advertisers' bids to the advertising exchange with the partner identifier received from the advertising exchange. Converting a partner identifier to another allows advertisers to target a particular user while the online system protects the user's identify.

Abstract: A seed cluster comprising a group of users who share a particular attribute and/or affiliation is determined by a social networking system. For each user of the seed cluster, other users and/or entities connected to the user in the social networking system are retrieved. For each retrieved other user or entity, the social networking system may determine whether the other user or entity exhibits the attribute or affiliation based on a random walk algorithm. A resulting targeting cluster of users and/or entities may be used for targeting advertisements targeting to members. A social networking system may also infer an affiliation for a user based on the user's interaction with a page, application, or entity where other users who interacted with the same page, application, or entity have the same affiliation.

Abstract: Users of a social networking system perform actions on various objects maintained by the social networking system. Some of these actions may indicate that the user has a negative sentiment for an object. To make use of this negative sentiment when providing content to the user, when the social networking system determines a user performs an action on an object, the social networking system identifies topics associated with the object and associates the negative sentiment with one or more of the topics. This association between one or more topics and negative sentiment may be used to decrease the likelihood that the social networking system presents content associated with a topic that is associated with a negative sentiment of the user.

Abstract: A social networking system user's interaction with a brand page may be tailored to match the user's interests. Content providers or page administrators of a brand page associate keywords with content posted to the brand page. A keyword may define a characteristic of a social networking system user to receive the content or may describe a characteristic of the content. The keywords are compared to a user profile of a user requesting the brand page and content posted to the brand page is selected for presentation to the user based on the user profile and the keywords. For example, content is presented to a user having a characteristic defined by criteria keyword. The selected content posted to the brand page is presented to the user requesting the brand page.

Abstract: An advertisement (ad) proxy server acts as a proxy for serving content of third-party ads to users of an online system, reducing data leakage from users to advertisers. The ad proxy server acts as an intermediate storage and access point for content included in advertisement, such as images and videos. When an advertisement from an advertiser is selected for presentation by the online system, an ad tag identifying the location of the content for the selected ad is retrieved and used to retrieve a copy of the advertisement content. The ad proxy server stores the copy of the advertisement content and generates a modified ad tag identifying the ad proxy server. The modified ad tag is sent to a client device, which retrieves the copy of the advertisement content from the ad proxy server rather than directly from the advertiser.

Abstract: An entity having a brand page maintained by a social networking system defines a sequence of content items associated with a brand page is determined. Different content items in the sequence include different information that is dependent on interaction between a user and the sequence. For example, content items in the sequence provide increasingly more detailed or complex information when progressing from the first content item to the last content item in the sequence. When a viewing user of a social networking system interacts with the brand page, prior interactions with the sequence by the viewing user are used to classify the viewing user and to select a content item from the sequence that is communicated to the viewing user.

Abstract: A story describing an activity performed by an interacting user is distributed to viewing users according to the influencer scores for the viewing users. Each influencer score can be calculated based at least in part on the influence of a viewing user on those users connected to the viewing user, and on the influencer scores for the users connected to the viewing user. Based on the determined influencer scores, at least one of the viewing users can be provided with the story describing the activity performed by the interacting user.

Abstract: A spring clamp retainer includes a first end configured for retaining a spring clamp in an unclamped state until removed, a second end configured for grasping with at least one finger. An intermediate portion extends between the first and second end that includes a top and bottom surface wherein the top surface is configured for resting a thumb and holding in the palm of a hand, and the bottom surface is configured for grasping with at least one other finger.

Abstract: Based on information used by the external system to identify a target user, the external system generates a target user hash identifier that is communicated to the social networking system along with a message. Using information from user profiles maintained by the social networking system, the social networking system generates hash identifiers for its users and compares the target user hash identifier to the generated hash identifiers hash identifiers for social networking system users are generated. The social networking system sends the message to a user associated with a hash identifier generated from user profile information that matches the target user hash identifier. Hence, an external application may communicate with social networking system users without accessing access information about the users maintained by the social networking system.

Abstract: A structure, which can be used as a portable shelter or tent, has a cover and structural elements disposed therein to permit the cover to lay flat or stand erect. The cover has two layers, one layer being thermally reflective and another layer being thermally absorptive. Similarly constructed removable panels can be attached to standoffs incorporated into the cover. The structure is reversible, so that the structure can either reject or absorb ambient heat. The standoffs are provided on each side of the cover and connections for attaching the removable panels to the standoffs are provided on each side of the removable panels. In this way, the removable panels can be attached to the interior or exterior of the structure with either side of a removable panel facing towards the cover.

Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.

Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.

Abstract: A story describing an activity performed by an interacting user is distributed to viewing users according to the influencer scores for the viewing users. Each influencer score can be calculated based at least in part on the influence of a viewing user on those users connected to the viewing user, and on the influencer scores for the users connected to the viewing user. Based on the determined influencer scores, at least one of the viewing users can be provided with the story describing the activity performed by the interacting user.

Abstract: A story describing an activity performed by an interacting user is distributed to viewing users according to the influencer scores for the viewing users. Each influencer score can be calculated based at least in part on the influence of a viewing user on those users connected to the viewing user, and on the influencer scores for the users connected to the viewing user. Based on the determined influencer scores, at least one of the viewing users can be provided with the story describing the activity performed by the interacting user.