Patents by Inventor Felipe Jimenez
Felipe Jimenez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240139269Abstract: A composition for the treatment of acne includes hydrolyzed Psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol(TM), which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.Type: ApplicationFiled: October 3, 2023Publication date: May 2, 2024Applicant: Envy Medical, Inc.Inventors: Felipe Jimenez, Lyndon Garcines, Susan Goldsberry, Senad Ibrulj
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Publication number: 20210277072Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: ApplicationFiled: October 15, 2020Publication date: September 9, 2021Applicants: ELASTOGENESIS, LLC, THE HOSPITAL FOR SICK CHILDRENInventors: Felipe JIMENEZ, Thomas MITTS, Aleksander HINEK
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Patent number: 10844101Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: GrantFiled: November 27, 2018Date of Patent: November 24, 2020Assignees: Elastogenesis, LLC, The Hospital for Sick ChildrenInventors: Felipe Jimenez, Thomas Mitts, Aleksander Hinek
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Publication number: 20190153045Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: ApplicationFiled: November 27, 2018Publication date: May 23, 2019Applicants: HUMAN MATRIX SCIENCES, LLC, THE HOSPITAL FOR SICK CHILDRENInventors: Felipe Jimenez, Thomas Mitts, Aleksander Hinek
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Patent number: 10167325Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: GrantFiled: June 20, 2016Date of Patent: January 1, 2019Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Felipe Jimenez, Thomas Mitts, Aleksander Hinek
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Patent number: 10004779Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.Type: GrantFiled: December 8, 2015Date of Patent: June 26, 2018Assignees: Human Matrix Services, LLC, The Hospital for Sick ChildrenInventors: Thomas Mitts, Felipe Jimenez, Aleksander Hinek
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Publication number: 20180064777Abstract: A composition for the treatment of acne includes hydrolyzed Psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.Type: ApplicationFiled: September 6, 2016Publication date: March 8, 2018Inventors: Felipe Jimenez, Lyndon Garcines, Susan Goldsberry, Senad Ibrulj
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Patent number: 9763900Abstract: This invention relates to chemistry and biochemistry applied to the field of medicine and is referred to a new method of prevention and therapeutic treatment of conformational diseases (CD), in particular to amyloid origin diseases by administrating an effective amount of one or more compounds, salts, prodrugs or solvates, which are considered herein as chemical chaperonins, of Formula I, Where: R1: -alkylenyl-C(O)NH-alkylenyl-R3, -alkylenyl-C(O)O—R4; R3: —COOH, —OH, —SH, —NH2, —NH-alkyl-, —NH-dithiocarbamate-alkyl, —N-alkyl-dithiocarbamate alkaline earth metal salts. R4: succinimidyl group. R2: —H, -alkyl; wherein the term “alkyl” is characterized by a linear or branched aliphatic chain, hydrogen and saturated carbon atoms, comprising a methyl, ethyl, n-propyl, iso-propyl, n-butyl or iso-butyl groups. Wherein, the term “alkylenyl” refers to a divalent analog of a linear or branched alkyl group, preferably ethylenyl (—CH2CH2—) or butylenyl (—CH2CH2CH2CH2—) radicals.Type: GrantFiled: December 30, 2013Date of Patent: September 19, 2017Assignee: CENTRO DE NEUROCIENCIAS DE CUBAInventors: Marquiza Sablón Carrazana, Chryslaine Rodriguez-Tanty, Myriam Marlene Altamirano Bustamante, Fernand Vedrenne Gutiérrez, Suchitil Rivera Marrero, Isaac Fernández Gómez, Rosa María López Barroso, Lina Andrea Rivillas Acevedo, Reyna Lara Martinez, Rafaela Perez Perera, Alberto Bencomo Martínez, María Guadalupe Domínguez Macouzet, Luis Felipe Jiménez García, Massiel Díaz Miranda, Julio Morán Andrade, Pedro Valdés Sosa, Alejandro Perera Pintado, Anaís Prats Capote, Sergio Agustín Islas Andrade
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Publication number: 20170002047Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: ApplicationFiled: June 20, 2016Publication date: January 5, 2017Applicants: HUMAN MATRIX SCIENCES, LLC, THE HOSPITAL FOR SICK CHILDRENInventors: Felipe JIMENEZ, Thomas MITTS, Aleksander HINEK
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Patent number: 9458197Abstract: The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of Elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of Elastin that penetrate into the tissue to which it is applied. The present invention describes compositions containing an elastin digest derived from proteolytic digestion of insoluble elastin derived from mammalian ligaments with a protein digesting composition, such as proteinase K. The elastin digest is a mixture of elastin peptides wherein the elastin peptide mixture comprises peptides of the sequence GXXPG, wherein X represents one of the natural amino acids. The elastin digest of the present invention may also comprise epitopes of cytokines, growth factors and di-peptides.Type: GrantFiled: September 8, 2014Date of Patent: October 4, 2016Assignee: Human Matrix Sciences, LLCInventors: Thomas Mitts, Felipe Jimenez
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Patent number: 9433587Abstract: A composition for the treatment of acne includes hydrolyzed psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.Type: GrantFiled: April 21, 2015Date of Patent: September 6, 2016Assignee: Envy Medical, Inc.Inventors: Felipe Jimenez, Lyndon Garcines, Susan Goldsberry, Senad Ibrulj
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Patent number: 9422334Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: GrantFiled: August 26, 2013Date of Patent: August 23, 2016Assignees: The Hospital For Sick Children, Human Matrix Sciences, LLCInventors: Felipe Jimenez, Thomas Mitts, Aleksander Hinek
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Publication number: 20160106691Abstract: This invention relates to chemistry and biochemistry applied to the field of medicine and is referred to a new method of prevention and therapeutic treatment of conformational diseases (CD), in particular to amyloid origin diseases by administrating an effective amount of one or more compounds, salts, prodrugs or solvates, which are considered herein as chemical chaperonins, of Formula I, Where: R1: -alkylenyl-C(O)NH-alkylenyl-R3, -alkylenyl-C(O)O—R4; R3: —COOH, —OH, —SH, —NH2, —NH-alkyl-, —NH-dithiocarbamate-alkyl, —N-alkyl-dithiocarbamate alkaline earth metal salts. R4: succinimidyl group. R2: —H, -alkyl; wherein the term “alkyl” is characterized by a linear or branched aliphatic chain, hydrogen and saturated carbon atoms, comprising a methyl, ethyl, n-propyl, iso-propyl, n-butyl or iso-butyl groups. Wherein, the term “alkylenyl” refers to a divalent analog of a linear or branched alkyl group, preferably ethylenyl (—CH2CH2—) or butylenyl (—CH2CH2CH2CH2—) radicals.Type: ApplicationFiled: December 30, 2013Publication date: April 21, 2016Inventors: MARQUIZA SABLON CARRAZANA, Chrislayne RODRIGUEZ-TANTY, Myriam Marlene ALTAMIRANO BUSTAMANTE, Fernand Vedrenne GUTIERREZ, Suchitil RIVERA MARRERO, Isaac Gomez FERNANDEZ, Rosa Maria LOPEZ BARROSO, Lina Andrea RIVILLAS ACEVEDOº, Reyna LARA MARTINEZ, Rafaela PEREZ PERERA, Alberto Guadalupe BENCOMO MARTINEZ, Maria Guadalupe DOMINGUEZ MACOUZET, Luis Felipe JIMENEZ GARCIA, Massiel DIAZ MIRANDA, Andreade Julio MORAN, Pedro VALDES SOSA, Alejandro PERERA PINADO, Anais PRATS CAPOTE, Sergio Agustin ISLAS ANDRADE
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Publication number: 20160089415Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra- tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.Type: ApplicationFiled: December 8, 2015Publication date: March 31, 2016Inventors: Thomas MITTS, Felipe JIMENEZ, Aleksander HINEK
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Patent number: 9254300Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.Type: GrantFiled: January 8, 2014Date of Patent: February 9, 2016Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Thomas Mitts, Felipe Jimenez, Aleksander Hinek
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Publication number: 20150238440Abstract: A composition for the treatment of acne includes hydrolyzed psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.Type: ApplicationFiled: April 21, 2015Publication date: August 27, 2015Inventors: Felipe Jimenez, Lyndon Garcines, Susan Goldsberry, Senad Ibrulj
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Publication number: 20150110755Abstract: The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides. The invention further comprises cosmetic and pharmaceutical treatment methods using the therapeutic fibroblast compositions of the invention.Type: ApplicationFiled: October 25, 2014Publication date: April 23, 2015Inventors: Felipe JIMENEZ, Thomas MITTS, Aleksander HINEK
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Patent number: 9006170Abstract: The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereof, suitable in facilitating synthesis and deposition of connective tissue matrix, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferation of these cell types. The present invention also describes methods of treatment of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.Type: GrantFiled: January 12, 2010Date of Patent: April 14, 2015Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Thomas Mitts, Felipe Jimenez, Aleksander Hinek, Severa Bunda
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Publication number: 20150004184Abstract: The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of Elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of Elastin that penetrate into the tissue to which it is applied. The present invention describes compositions containing an elastin digest derived from proteolytic digestion of insoluble elastin derived from mammalian ligaments with a protein digesting composition, such as proteinase K. The elastin digest is a mixture of elastin peptides wherein the elastin peptide mixture comprises peptides of the sequence GXXPG, wherein X represents one of the natural amino acids. The elastin digest of the present invention may also comprise epitopes of cytokines, growth factors and di-peptides.Type: ApplicationFiled: September 8, 2014Publication date: January 1, 2015Inventors: Thomas MITTS, Felipe JIMENEZ
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Patent number: 8871707Abstract: The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides. The invention further comprises cosmetic and pharmaceutical treatment methods using the therapeutic fibroblast compositions of the invention.Type: GrantFiled: September 16, 2010Date of Patent: October 28, 2014Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Felipe Jimenez, Thomas F. Mitts, Aleksander Hinek