Patents by Inventor Felipe LOPEZ-HILFIKER
Felipe LOPEZ-HILFIKER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11908673Abstract: An ion molecule reactor for generating analyte ions from analytes comprises: a) a reaction volume in which reagent ions can interact with the analytes in order to form analyte ions; b) at least one analyte inlet for introducing the analytes along an inlet path into the reaction volume whereby, preferably, the inlet path runs essentially along at least a first section of the predefined transit path in the reaction volume; c) at least one reagent ion source and/or at least one reagent ion inlet for providing reagent ions into the reaction volume; d) optionally, at least one ion guide comprising an electrode arrangement which is configured for producing an alternating electrical, magnetic and/or electromagnetic field, that allows for guiding the reagent ions and/or the analyte ions at least along a section of the predefined transit path, preferably along the whole transit path, through the reaction volume.Type: GrantFiled: October 19, 2018Date of Patent: February 20, 2024Assignee: TOFWERK AGInventors: Felipe Lopez-Hilfiker, Manuel Hutterli, Marc Gonin, Carsten Stoermer, Michael Kamrath
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Publication number: 20230274924Abstract: The invention relates to a method for mass analysing positively charged ions and negatively charged ions with a mass analyser arrangement (10). The method includes inserting the positively charged ions and the negatively charged ions via an intake (13) of the mass analyser arrangement (10) into a mass analysis chamber (14) of the mass analyser arrangement (10). Furthermore, the method includes transferring inside the mass analysis chamber (14) the positively charged ions from the intake (13) to a first mass analyser (11) of the mass analyser arrangement (10) and mass analysing the positively charged ions with the first mass analyser (11) and transferring inside the mass analysis chamber (14) the negatively charged ions from the intake (13) to a second mass analyser (12) of the mass analyser arrangement (10) and mass analysing the negatively charged ions with the second mass analyser (12).Type: ApplicationFiled: February 27, 2023Publication date: August 31, 2023Applicant: TOFWERK AGInventors: Urs ROHNER, Felipe LOPEZ-HILFIKER
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Publication number: 20220359185Abstract: The invention relates to a chemical ionisation method, in particular an adduct ionisation method, for ionising a sample including analytes to be ionised, wherein ligand compound ions formed from reactant ions and a dopant substance are made available in a reaction volume (2), wherein said sample with said analytes is introduced into said reaction volume (2) to react with said ligand compound ions to form adduct ions and a neutral byproduct, said adduct ions including ionised analytes being adducts of said reactant ions and the respective said analytes, wherein said reactant ions and said dopant substance provide a higher binding energy when binding together to said ligand compound ions than a binding energy said reactant ions and a ligand forming substance provide when binding together, wherein said ligand forming substance is present at least in traces in said reaction volume (2) when said sample with said analytes react with said ligand compound ions to form said adduct ions and said neutral byproduct.Type: ApplicationFiled: May 9, 2022Publication date: November 10, 2022Applicant: TOFWERK AGInventor: Felipe LOPEZ-HILFIKER
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Patent number: 11227755Abstract: An autosampler for obtaining mass spectra from a plurality of fluid samples, in particular gaseous samples including a plurality of containers including sample sources providing the samples, wherein each one of the containers provides a docking port for being connected with a connector for enabling access to an inside of the respective container via the connector in order to obtain the respective sample from the respective container via said connector. The autosampler further includes an ionisation source for ionising at least a part of the samples, and a mass analyser for obtaining the mass spectra from the ions. The ionisation source is moveable within the autosampler sequentially to each of the containers for connecting the connector to the docking port of the respective container for collecting the sample from the respective container for ionising at least a part of the sample and obtaining the mass spectra from the ions.Type: GrantFiled: February 1, 2019Date of Patent: January 18, 2022Assignee: TOFWERK AGInventors: Marc Gonin, Felipe Lopez-Hilfiker, Manuel Hutterli, Matthias Erb, Marc Pfander
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Publication number: 20210066058Abstract: The invention relates to an autosampler (1) for obtaining mass spectra from a plurality of fluid samples, in particular gaseous samples. This autosampler (1) comprises a plurality of containers (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) comprising sample sources (3.1, 3.2, 3.3, 3.4, 3.5, 3.6) providing the samples, wherein each one of the containers (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) provides a docking port (4.1, 4.2, 4.3, 4.4, 4.5, 4.6) for being connected with a connector (5) for enabling access to an inside of the respective container (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) via the connector (5) when the connector (5) is connected to the respective docking port (4.1, 4.2, 4.3, 4.4, 4.5, 4.6) in order to obtain the respective sample from the respective container (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) via said connector (5). Thereby, the connector (5) is connectable to and detachable from each docking port (4.1, 4.2, 4.3, 4.4, 4.5, 4.6).Type: ApplicationFiled: February 1, 2019Publication date: March 4, 2021Applicant: TOFWERK AGInventors: Marc GONIN, Felipe LOPEZ-HILFIKER, Manuel HUTTERLI, Matthias ERB, Marc PFANDER
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Patent number: 10811240Abstract: The invention relates to an apparatus and a method for analysing a chemical composition of aerosol particles. The apparatus comprises an extractive electrospray ionisation source for extracting components, in particular organic compounds, from the aerosol particles and for ionising the components to ions, and a mass analyser, in particular a time of flight mass analyser, for analysing the ions, the mass analyser fluidly coupled to the extractive electrospray ionisation source. The method includes the steps of extracting components, in particular organic compounds, from the aerosol particles with an extractive electrospray ionisation source and ionising the components with the extractive electrospray ionisation source to ions, transferring the ions to a mass analyser, in particular a time of flight mass analyser, the mass analyser being fluidly coupled to the extractive electrospray ionisation source, and analysing the ions with the mass analyser.Type: GrantFiled: September 7, 2017Date of Patent: October 20, 2020Assignee: TOFWERK AGInventors: Felipe Lopez-Hilfiker, Marc Gonin, Mike Cubison
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Publication number: 20200243317Abstract: An ion molecule reactor for generating analyte ions from analytes comprises: a) a reaction volume in which reagent ions can interact with the analytes in order to form analyte ions; b) at least one analyte inlet for introducing the analytes along an inlet path into the reaction volume whereby, preferably, the inlet path runs essentially along at least a first section of the predefined transit path in the reaction volume; c) at least one reagent ion source and/or at least one reagent ion inlet for providing reagent ions into the reaction volume; d) optionally, at least one ion guide comprising an electrode arrangement which is configured for producing an alternating electrical, magnetic and/or electromagnetic field, that allows for guiding the reagent ions and/or the analyte ions at least along a section of the predefined transit path, preferably along the whole transit path, through the reaction volume.Type: ApplicationFiled: October 19, 2018Publication date: July 30, 2020Applicant: TOFWERK AGInventors: Felipe LOPEZ-HILFIKER, Manuel HUTTERLI, Marc GONIN, Carsten STOERMER, Michael KAMRATH
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Publication number: 20190237316Abstract: The invention relates to an apparatus and a method for analysing a chemical composition of aerosol particles. The apparatus comprises an extractive electrospray ionisation source for extracting components, in particular organic compounds, from the aerosol particles and for ionising the components to ions, and a mass analyser, in particular a time of flight mass analyser, for analysing the ions, the mass analyser fluidly coupled to the extractive electrospray ionisation source. The method includes the steps of extracting components, in particular organic compounds, from the aerosol particles with an extractive electrospray ionisation source and ionising the components with the extractive electrospray ionisation source to ions, transferring the ions to a mass analyser, in particular a time of flight mass analyser, the mass analyser being fluidly coupled to the extractive electrospray ionisation source, and analysing the ions with the mass analyser.Type: ApplicationFiled: September 7, 2017Publication date: August 1, 2019Applicant: TOFWERK AGInventors: Felipe LOPEZ-HILFIKER, Marc GONIN, Mike CUBISON