Abstract: The present invention relates in a first aspect to a plug flow tubular bioreactor having an integral or multi-part tube adapted for cultivation, and, optionally, infection, viral transduction, or transfection of eukaryotic cells. In a further aspect, the present invention relates to a plug flow tubular bioreactor system comprising the plug flow tubular bioreactor according to the present invention. Further, the present invention relates to a method for preparing virus particles, vectors, cells or other molecules including toxic molecules using the plug flow tubular bioreactor or the system according to the present invention. Finally, the present invention relates to the use of a plug flow tubular bioreactor for the preparation of virus particles, vectors including viral vectors, cells including modified cells or other molecules including toxic molecules.

Abstract: The present invention relates in a first aspect to a plug flow tubular bioreactor having an integral or multi-part tube adapted for cultivation, and, optionally, infection, viral transduction, or transfection of eukaryotic cells. In a further aspect, the present invention relates to a plug flow tubular bioreactor system comprising the plug flow tubular bioreactor according to the present invention. Further, the present invention relates to a method for preparing virus particles, vectors, cells or other molecules including toxic molecules using the plug flow tubular bioreactor or the system according to the present invention. Finally, the present invention relates to the use of a plug flow tubular bioreactor for the preparation of virus particles, vectors including viral vectors, cells including modified cells or other molecules including toxic molecules.

Abstract: A self-centring and energy dissipating seismic isolation device of the elastomeric frictional-type for structures and industrial equipment comprises: first and second metal plates respectively joined, one to the structure or equipment and the other to its foundations, the first metal plate being fixed thereto and the second metal plate being rotatably joined thereto by a column; at least one elastomeric ring between the plates; and a central restrictive bar orthogonally joined to the first plate and extending through the elastomeric ring and through a central through-hole in the second plate, a nut being screwed to the free end of the bar and having a spherical curved-convex bottom in sliding contact and corresponding with a spherical curved-concave inner surface part of the central through-hole. An isolation system can comprise several of these devices and columns or just one pair of devices at the ends of a central column in combination with sliding support pillars.

Abstract: The invention relates to a combination of a foundation anchor and energy damper for vertical tanks or similar containers for liquids with a thin wall and continuous support, comprising an energy dissipation component centrally connected to a foundation anchor component by means of a linking component, the energy dissipation component comprising one or more superimposed and horizontally arranged energy dissipating plates with a rhombic shape truncated at the vertices thereof, wherein the shorter diagonal is normal to the wall of the tank and the side ends or vertices corresponding to the longer diagonal have quadrangular extensions for support on a load transmission component that is connected to the wall of the tank so as to transmit and distribute the forces developed by the one or more energy dissipating plates. Alternatively, the energy dissipating plates are trapezoidal with the longer parallel side tangential to the wall of the tank.

Abstract: A self-centring and energy dissipating seismic isolation device of the elastomeric frictional-type for structures and industrial equipment comprises: first and second metal plates respectively joined, one to the structure or equipment and the other to its foundations, the first metal plate being fixed thereto and the second metal plate being rotatably joined thereto by a column; at least one elastomeric ring between the plates; and a central restrictive bar orthogonally joined to the first plate and extending through the elastomeric ring and through a central through-hole in the second plate, a nut being screwed to the free end of the bar and having a spherical curved-convex bottom in sliding contact and corresponding with a spherical curved-concave inner surface part of the central through-hole. An isolation system can comprise several of these devices and columns or just one pair of devices at the ends of a central column in combination with sliding support pillars.

Abstract: The invention relates to a combination of a foundation anchor and energy damper for vertical tanks or similar containers for liquids with a thin wall and continuous support, comprising an energy dissipation component centrally connected to a foundation anchor component by means of a linking component, the energy dissipation component comprising one or more superimposed and horizontally arranged energy dissipating plates with a rhombic shape truncated at the vertices thereof, wherein the shorter diagonal is normal to the wall of the tank and the side ends or vertices corresponding to the longer diagonal have quadrangular extensions for support on a load transmission component that is connected to the wall of the tank so as to transmit and distribute the forces developed by the one or more energy dissipating plates. Alternatively, the energy dissipating plates are trapezoidal with the longer parallel side tangential to the wall of the tank.

Abstract: The present invention relates in a first aspect to a plug flow tubular bioreactor having an integral or multi-part tube adapted for cultivation, and, optionally, infection, viral transduction, or transfection of eukaryotic cells. In a further aspect, the present invention relates to a plug flow tubular bioreactor system comprising the plug flow tubular bioreactor according to the present invention. Further, the present invention relates to a method for preparing virus particles, vectors, cells or other molecules including toxic molecules using the plug flow tubular bioreactor or the system according to the present invention. Finally, the present invention relates to the use of a plug flow tubular bioreactor for the preparation of virus particles, vectors including viral vectors, cells including modified cells or other molecules including toxic molecules.