Patents by Inventor Felipe Vadillo-Ortega

Felipe Vadillo-Ortega has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of predicting fetal membrane rupture based on pro-matrix metalloproteinase-9 (pro-mmp-9)
    Patent number: 5698404
    Abstract: Disclosed is a method of predicting the onset of fetal membrane rupture in a gestative female comprising the step of assaying a tissue or fluid sample of fetal membrane origin obtained from the female for the presence of pro-metalloproteinase-9 (pro-mmd-9). The presence of pro-mmd-9 in the sample is a positive indication of the onset of fetal membrane rupture. Also disclosed is a method of delaying the onset of female membrane rupture in a gestative female comprising the step of administering to the female an MMP-9 inhibitor in an amount effective to delay fetal membrane rupture. Further disclosed is a method of inducing labor in a gestative female comprising the administration of an MMP-9 activator or MMP-9 itself in an amount effective to induce fetal membrane rupture, and thus facilitate the onset of labor.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: December 16, 1997
    Assignee: University of Pennsylvania
    Inventors: Jerome Frank Strauss, III, Felipe Vadillo-Ortega
  • Method of predicting fetal membrane rupture based on matrix metalloproteinase-9 activity
    Patent number: 5641636
    Abstract: Disclosed is a method of predicting the onset of fetal membrane rupture in a gestative female comprising the step of assaying a tissue or fluid sample of fetal membrane origin obtained from the female for the presence of metalloproteinase-9 activity. The presence of such activity in the sample is a positive indication of the onset of fetal membrane rupture. Also disclosed is a method of delaying the onset of female membrane rupture in a gestative female comprising the step of administering to the female an MMP-9 inhibitor in an amount effective to delay fetal membrane rupture. Further disclosed is a method of inducing labor in a gestative female comprising the administration of an MMP-9 activator or MMP-9 itself in an amount effective to induce fetal membrane rupture, and thus facilitate the onset of labor.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: June 24, 1997
    Assignee: University of Pennsylvania
    Inventors: Jerome Frank Strauss, III, Felipe Vadillo-Ortega