Patents by Inventor Felix Cuevas

Felix Cuevas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alcoxyamino derivatives for treating pain and pain related conditions
    Patent number: 11401270
    Abstract: The present invention relates to new compounds of formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC) and the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: August 2, 2022
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Félix Cuevas-Cordobés
  • Propanamine derivatives for treating pain and pain related conditions
    Patent number: 11111220
    Abstract: The present invention relates to new compounds of formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: September 7, 2021
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Félix Cuevas-Cordobés
  • Piperazine derivatives having multimodal activity against pain
    Patent number: 10745361
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 18, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia-Lopez
  • Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions
    Patent number: 10590140
    Abstract: The present invention relates to new compounds of general formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially ?2?-1 subunit of voltage-gated calcium channels or dual activity towards subunit ?2? of voltage-gated calcium channels (VGCC), especially ?2?-1 subunit of voltage-gated calcium channels, and noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: March 17, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales
  • Piperazine derivatives having multimodal activity against pain
    Patent number: 10351535
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 16, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez
  • Tricyclic triazolic compounds
    Patent number: 10035805
    Abstract: The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: July 31, 2018
    Assignee: ESTEVE PHARMACEUTECALS, S.A.
    Inventors: Félix Cuevas-Cordobés, Miguel Angel Pericás-Brondo
  • Piperidine derivatives having multimodal activity against pain
    Patent number: 9981942
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 29, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez
  • Piperidine compounds having multimodal activity against pain
    Patent number: 9902711
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: February 27, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez, Eva Maria Ayet Galcera, Maria Teresa Serafini Cabanes
  • Tricyclic triazolic compounds
    Patent number: 9512142
    Abstract: The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: December 6, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luís Díaz-Fernández, Carmen Almansa-Rosales, Félix Cuevas-Cordobés
  • Bicyclic tetrahydropyrrole compounds
    Patent number: 9271959
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: March 1, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Miguel Angel Pericas-Brondo, Antonio Torrens-Jover, Susana Yenes-Minguez, Felix Cuevas Cordobes, Carmen Garcia Granda
  • Bicyclic tetrahydropyrrole compounds
    Patent number: 8372990
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: February 12, 2013
    Assignee: Laboratorios Del Dr. Esteve S.A.
    Inventors: Miguel Angel Pericas-Brondo, Antonio Torrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobés, Carmen Garcia Granda
  • Tricyclic triazolic compounds
    Patent number: 8362011
    Abstract: The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of formula (I), Wherein R1 and R2 are as defined in the description.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: January 29, 2013
    Assignee: Laboratories del Dr. Esteve, S.A.
    Inventors: Miguel Angel Pericas-Brondo, Antoni Torrens-Jover, Félix Cuevas-Cordobes, Susana Yenes-Minguez
  • Bicyclic tetrahydropyrrole compounds
    Patent number: 8299113
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: October 30, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Miguel Angel Pericas-Brondo, Antonio Torrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobes, Carmen Garcia Granda
  • TRICYCLIC TRIAZOLIC COMPOUNDS
    Publication number: 20100298309
    Abstract: The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of formula (I), Wherein R1 and R2 are as defined in the description.
    Type: Application
    Filed: December 5, 2008
    Publication date: November 25, 2010
    Inventors: Miguel Angel Pericas-Brondo, Antoni Torrens-Jover, Félix Cuevas-Cordobes, Susana Yenes-Minguez
  • SUBSTITUTED 3-AMINO-4 -HYDROXY PYRROLIDINES COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20100168093
    Abstract: The present invention relates to substituted pyrrolidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animal.
    Type: Application
    Filed: April 30, 2007
    Publication date: July 1, 2010
    Inventors: Miguel Angel Pericas-Brondo, Antoni Torrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobés, Carmen Garcia Granda
  • Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them
    Patent number: 7678765
    Abstract: The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: March 16, 2010
    Assignee: Pharma Mar, S.A.
    Inventors: Ignacio Rodriguez, Concepción Polanco, Felix Cuevas, Paloma Mandez, Carmen Cuevas, Pilar Gallego, Simon Munt, Ignacio Manzanares
  • Bicyclic Tetrahydropyrrole Compounds
    Publication number: 20100029738
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Application
    Filed: April 30, 2007
    Publication date: February 4, 2010
    Inventors: Miguel Angel Pericas-Brondo, Antoni Torrrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobes, Carmen Garcia Granda
  • BICYCLIC TETRAHYDROPYRROLE COMPOUNDS
    Publication number: 20090318524
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Application
    Filed: April 30, 2007
    Publication date: December 24, 2009
    Inventors: Miguel Angel Pericas-Brondo, Antonio Torrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobés, Carmen Garcia Granda
  • Production Process for Bicyclic Tetrahydropyrrole Compounds
    Publication number: 20090306403
    Abstract: The present invention relates to a process using the Pauson-Khand Reaction to produce substituted bicyclic tetrahydropyrrole compounds of general formula (I)
    Type: Application
    Filed: April 30, 2007
    Publication date: December 10, 2009
    Inventors: Miguel Angel Pericas-Brondo, Antonio Torrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobés, Carmen Garcia Granda
  • Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them
    Patent number: 7348310
    Abstract: The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: March 25, 2008
    Assignee: Pharma Mar, S.A.
    Inventors: Ignacio Rodriguez, Concepción Polanco, Felix Cuevas, Paloma Mendez, Carmen Cuevas, Pilar Gallego, Simon Munt, Ignacio Manzanares