Patents by Inventor Felix D. Karim

Felix D. Karim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mylks as modifiers of branching morphogenesis and methods of use
    Patent number: 8105785
    Abstract: Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: January 31, 2012
    Assignee: Exelixis, Inc.
    Inventors: Gregory D. Plowman, Felix D. Karim, Candace Swimmer, Hinrich Alexander Habeck, Thomas I. Koblizek, Stefan Schulte-Merker, Ulrike Eisenmann, Gordon Mark Stott, Torsten Trowe, Andreas Michael Vogel, Joerg Heinrich Odenthal, Jochen Konrad Scheel, Torsten Tilmann Will, Yinsheng Jin, Lynn Margaret Bjerke, Timothy S. Heuer
  • Mylks as Modifiers of Branching Morphogenesis and Methods of Use
    Publication number: 20080317738
    Abstract: Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
    Type: Application
    Filed: June 18, 2004
    Publication date: December 25, 2008
    Applicant: Exelixis, Inc.
    Inventors: Gregory D. Plowman, Felix D. Karim, Candace Swimmer, Hinrich Alexander Habeck, Thomas I. Koblizek, Stefan Schulte-Merker, Ulrike Eisenmann, Gordon Mark Stott, Torsten Trowe, Andreas Michael Vogel, Joerg Heinrich Odenthal, Jochen Konrad Scheel, Torsten Tilmann Will, Yinsheng Jin, Lynn Margaret Bjerke, Timothy S. Heuer
  • Mbms as Modifiers of Branching Morphogenesis and Methods of Use
    Publication number: 20080213247
    Abstract: Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.
    Type: Application
    Filed: October 22, 2003
    Publication date: September 4, 2008
    Inventors: Gregory D. Plowman, Felix D. Karim, Candace Swimmer, Hinrich Alexander Habeck, Thomas I. Koblizek, Stefan Schulte-Merker, Ulrike Langheinrich, Gordon Mark Stott, Torsten Trowe, Andreas Michael Vogel, Joerg Heinrich Odenthal, Jochen Konrad Scheel, Torsten Tilmann Will, Yisheng Jin, Lynn Margaret Bjerke, Bing Hai, Joanne I. Adamkewicz, Kim Licketeig, R. Glenn R. Hammonds, Craig D. Amundsen, Haiguang Zhang, Monique Nicoll
  • CRBs as Modifiers of Branching Morphogenesis and Methods of Use
    Publication number: 20080163386
    Abstract: Human CRB genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CRB are provided.
    Type: Application
    Filed: January 28, 2007
    Publication date: July 3, 2008
    Applicant: EXELIXIS, INC.
    Inventors: Felix D. Karim, Linda Nolan Keyes, Gregory D. Plowman, Michael Martin Ollmann, Mark E. Maxwell, Thierry Tidiane Diagana
  • MAP4Ks as modifiers of branching morphogenesis and methods of use
    Publication number: 20030113782
    Abstract: Human MAP4K genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAP4K are provided.
    Type: Application
    Filed: November 25, 2002
    Publication date: June 19, 2003
    Inventors: Felix D. Karim, Linda Nolan Keyes, Gregory D. Plowman
  • CRBs as modifiers of branching morphogenesis and methods of use
    Publication number: 20030100005
    Abstract: Human CRB genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CRB are provided.
    Type: Application
    Filed: November 25, 2002
    Publication date: May 29, 2003
    Inventors: Felix D. Karim, Linda Nolan Keyes, Gregory D. Plowman, Michael Martin Ollmann, Mark E. Maxwell, Thierry Tidiane Diagana
  • Methods for identifying anti-cancer drug targets
    Patent number: 6531644
    Abstract: Methods, transformation constructs, and transgenic animals for identifying anti-tumor agents and anti-tumor drug targets are described. The transformation constructs are used to generate transgenic animals that have altered expression of an oncogene or tumor suppressor gene in a target tissue that is dispensable for viability and reproduction. In some embodiments, the altered expression results in abnormal proliferation of the target tissue and normal proliferation in all other tissues. Anti-tumor drug targets can be identified by generating progeny of the transgenic animals that have mutations in various genes. Gene mutations that result in a specific reduction or killing of the target tissue are identified as possible anti-tumor drug targets and are further evaluated. Anti-tumor agents are identified that mimic the effect of the gene mutations that result in specific reduction of the target tissue.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: March 11, 2003
    Assignee: Exelixis, Inc.
    Inventors: Geoffrey Duyk, Felix D. Karim, Casey Kopczynski, Jenny Kopczynski
  • Methods for identifying anti-cancer drug targets
    Patent number: 6489127
    Abstract: Methods, transformation constructs, and transgenic animals for identifying anti-tumor agents and anti-tumor drug targets are described. The transformation constructs are used to generate transgenic animals that have altered expression of an oncogene or tumor suppressor gene in a target tissue that is dispensable for viability and reproduction. In some embodiments, the altered expression results in abnormal proliferation of the target tissue and normal proliferation in all other tissues. Anti-tumor drug targets can be identified by generating progeny of the transgenic animals that have mutations in various genes. Gene mutations that result in a specific reduction or killing of the target tissue are identified as possible anti-tumor drug targets and are further evaluated. Anti-tumor agents are identified that mimic the effect of the gene mutations that result in specific reduction of the target tissue.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: December 3, 2002
    Assignee: Exelixis, Inc.
    Inventors: Geoffrey Duyk, Felix D. Karim