Abstract: A method for testing at least one electronic control device as a virtual control device on a simulator, which includes at least one simulator computing unit. The electronic control device has a hardware configuration with at least one computing unit (and an external interface for exchanging data. A software configuration is assigned to the hardware configuration. The electronic control device is mapped to the virtual control device in that the internal functionality of the software configuration of the electronic control device is taken over as the internal functionality of a software configuration of the virtual control device. External interface functionality of the electronic control device is replaced by a data transfer functionality of the software configuration of the simulator computing unit. The software configuration of the virtual control device being translated into executable code for the simulator computing unit and executed on the simulator.

Abstract: Compositions and methods for increasing proliferation and/or de-differentiation of postmitotic mammalian cardiomyocytes are disclosed to slow, reduce, or prevent the onset of cardiac damage. In addition, the methods and compositions of the invention can used to produce de-differentiated cardiomyocytes, which can then be used in tissue grafting, implantation or transplantation. The invention is based, in part, on the discovery that postmitotic mammalian cardiomyocytes can proliferate as a result of targeted disruption of p38 MAP kinase. p38 inhibition with optional growth factor stimulation can induce cytokinesis in adult cardiomyocytes.