Abstract: The present invention relates to a modified antibody comprising a heavy chain and a light chain, wherein the heavy chain or/and the light chain comprises one or more first recognition site(s) for the transglutaminase from Kutzneria albida (KalbTG) or a functionally active variant thereof. The one or more first recognition site(s) are introduced at one or more selected position(s) within the antibody's heavy chain and/or light chain. The invention further relates to one or more nucleic acids encoding the modified antibody according to the invention as well as a covalent conjugate comprising (i) the modified antibody according to the invention and (ii) one or more non-antibody moieties (payload(s)) covalently conjugated to the one or more first recognition site(s) either directly or via a first linker. In certain embodiments, the non-antibody moiety comprises a therapeutic entity and optionally a second linker.

Abstract: A sintered yttrium oxide body having a total impurity level of 40 ppm or less, a density of not less than 4.93 g/cm3, wherein the sintered yttrium oxide body has at least one surface comprising at least one pore, wherein no pore is larger than 5 ?m in diameter. A process for making the sintered yttrium oxide body is also disclosed.

Abstract: A height-adjustable device has synchronously height-adjustable lifting devices each having a standing and lifting element, which are height-adjustable relative thereto. The height adjustment is configured to be carried out via pulling elements, formed by redirection devices, to raise the lifting element relative to the standing element. Each pulling element is secured in a non-positive or positive locking manner to lifting devices, and each are configured such that a lengthening in the region of the first lifting device brings about a synchronous shortening in the region of the second lifting device. Each pulling element is constructed to raise only the one lifting element relative to the standing element. The height-adjustable device has a locking device that locks the pulling elements by a non-positive or positive locking engagement on the corresponding one of the pulling elements. The locking device is constructed to synchronise the movement of the pulling elements.

Abstract: A height-adjustable device has synchronously height-adjustable lifting devices each having a standing and lifting element, which are height-adjustable relative thereto. The height adjustment is configured to be carried out via pulling elements, formed by redirection devices, to raise the lifting element relative to the standing element. Each pulling element is secured in a non-positive or positive locking manner to lifting devices, and each are configured such that a lengthening in the region of the first lifting device brings about a synchronous shortening in the region of the second lifting device. Each pulling element is constructed to raise only the one lifting element relative to the standing element. The height-adjustable device has a locking device that locks the pulling elements by a non-positive or positive locking engagement on the corresponding one of the pulling elements. The locking device is constructed to synchronise the movement of the pulling elements.

Abstract: A method and apparatus for the manufacture of collar inserts made of a base insert and a seal insert, by which the base insert and the seal insert are introduced in the sealing press lying aligned on each other. The base insert and the seal insert are provided with at least two truing openings, respectively, corresponding in arrangement to truing mandrels on a support, the latter being insertable in a sealing press with the base insert and the seal insert disposed on each other aligned with the truing mandrels inserted in the respective truing openings of the inserts.