Patents by Inventor Felix Helmut Schmidt
Felix Helmut Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4113871Abstract: Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.Type: GrantFiled: April 8, 1976Date of Patent: September 12, 1978Assignee: Boehringer Mannheim GmbHInventors: Kurt Stach, deceased, Elmar Bosies, Ruth Heerdt, Hans-Frieder Kuhnle, Felix Helmut Schmidt
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Patent number: 4060626Abstract: Indole-carboxylic acid compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl or alkoxy radical or halogen;R.sub.2 is halogen; lower alkyl or alkoxy radical; orR.sub.1 and R.sub.2 can together also form an alkylene bridge containing 3 to 5 carbon atoms, which can optionally contain one or more double bonds; and, but less preferably, when R.sub.1 is a lower alkyl or alkoxy radical, R.sub.2 can also be a hydrogen atom, and physiologically compatible salts and esters thereof,Are outstandingly effective as blood sugar-lowering agents.Type: GrantFiled: May 4, 1976Date of Patent: November 29, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Vladimir Hrstka, Manfred Hubner, Manfred Kuhr, Felix Helmut Schmidt, Walter Aumuller
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Patent number: 4060634Abstract: A blood sugar lowering composition comprising as the active material particulate glibenclamide having a surface area of about 3 to 10 m.sup.2 /g in admixture with a pharmacologically acceptable non-ionic wetting agent present in about 2 to 20 times the weight of the glibenclamide. The preferred wetting agent is polyoxyethylene stearate present in about 5 to 10 times the weight of the glibenclamide.Type: GrantFiled: May 20, 1976Date of Patent: November 29, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Werner Rothe, Helmut Heinemann, Felix Helmut Schmidt, Gunter Betzien
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Patent number: 4029666Abstract: Benzenesulfonyl-ureas of the formula ##STR1## wherein X represents ##STR2## IN WHICH Z represents hydrogen, halogen, a trifluormethyl group, an alkyl or an alkoxyl radical in 4- or 5-position, or ##STR3## Y represents --CH.sub.2 --CH.sub.2 --, --CH--(CH.sub.3)--CH.sub.2 --or --CH.sub.2 --CH--(CH.sub.3)--,R represents a radical ofA. pentamethylene-imine, which may be substituted by 1 to 3 methyl group or by an endoalkylene group of 1 to 3 carbon atoms,B. hexamethylene-imine, which may be substituted by an endoethylene group in .beta.-.epsilon.-position,C. heptamethylene-imine,D. hexahydro-isoindoline, tetrahydro-isoindoline, 4,7-endoalkylene-hexahydro-, 4,7-endoalkylene-tetrahydro-isoindoline, the endoalkylene group of which may contain 1 - 2 carbon atoms and the double linkage of the tetrahydro group being in 5,6-position,E. N-3-azaspiro-[5,5]-undecane,F. the groups ##STR4## and their pharmaceutically acceptable alkali- or alkaline earth-metal salts.Type: GrantFiled: December 8, 1971Date of Patent: June 14, 1977Assignee: Hoechst AktiengesellschaftInventors: Helmut Weber, Walter Aumuller, Karl Muth, Rudi Weyer, Felix Helmut Schmidt
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Patent number: 4025519Abstract: Sulfonyl-ureas of the formula ##STR1## wherein X represents a heteroaromatic 5- or 6-ring substituted, if desired, by one or two methyl groups and/or annellated with benzene, which ring may contain in addition to a nitrogen atom a further nitrogen, oxygen or sulfur atom and which, in vicinal position to the nitrogen atom, is linked to the rest of the molecule portion, R is alkyl having 1 to 3 carbon atoms, R.sup.1 is alkyl having 3 to 6 carbon atoms, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkenyl, alkylcycloalkenyl having each 5 to 9 carbon atoms, cyclohexenylmethyl, chlorocyclohexyl, bicycloheptenylmethyl, bicycloheptylmethyl, bicycloheptenyl, bicycloheptyl, nortricyclyl, adamantyl, benzyl, which as substance or in form of the salts thereof have hypoglycemic properties and are distinguished by a strong and continuous lowering of the blood sugar level, process for preparing them as well as pharmaceutical preparations containing the sulfonyl-ureas as an active substance.Type: GrantFiled: April 15, 1975Date of Patent: May 24, 1977Assignee: Hoechst AktiengesellschaftInventors: Rudi Weyer, Walter Aumuller, Volker Hitzel, Felix Helmut Schmidt
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Patent number: 4017539Abstract: New biguanide compounds of the formula: ##STR1## wherein A is saturated or unsaturated cycloaliphatic hydrocarbyl, and the physiologically compatible salts thereof; display outstanding anti-diabetic effectiveness in the treatment of diabetes mellitus, without showing the typical side effects of biguanide treatment, viz., lactacidosis.Type: GrantFiled: May 7, 1975Date of Patent: April 12, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Elmar Bosies, Kurt Stach, Felix Helmut Schmidt, Ruth Heerdt, Helmut Weber
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Patent number: 3996241Abstract: New indole derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are hydrogen or halogen or lower alkyl or, taken together, represent a --CH=CH-CH=CH- bridge, with the proviso that R.sub.1 and R.sub.2 are not both hydrogen, and wherein, when R.sub.2 is halogen or alkyl, R.sub.1 can also be alkoxy;Are outstandingly effective in blood sugar lowering action in mammals.Type: GrantFiled: October 22, 1974Date of Patent: December 7, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Ruth Heerdt, Manfred Hubner, Felix Helmut Schmidt, Kurt Stach
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Patent number: 3988317Abstract: New heterocyclic-substituted nebularin compounds of the formula: ##SPC1##WhereinR.sub.1 is hydrogen, halogen or amino;R.sub.2 and R.sub.3, which may be the same or different, are hydrogen, hydroxyl, lower alkyl, alkoxy or hydroxyalkyl; andn is 2 or 3 or, when R.sub.1 is a halogen atom or an amino group, n can also be 1; and the pharmacologically compatible salts thereof;Are outstandingly effective in reducing body fat levels in mammals, e.g., the concentration of free fatty acids, of triglycerides and of cholesterol in serum.Type: GrantFiled: November 2, 1972Date of Patent: October 26, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Wolfgang Kampe, Klaus Koch, Kurt Stach, Harald Stork, Felix Helmut Schmidt
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Patent number: 3979520Abstract: Rapidly resorbable particulate glibenclamide having a particle surface area of active material of at least 3 m.sup.2 /g is produced by precipitating the active material from its solution in an organic solvent or in water or aqueous alcohol, preferably rendered alkaline, using water which is preferably acidified.Type: GrantFiled: September 20, 1974Date of Patent: September 7, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Werner Rothe, Helmut Heinemann, Felix Helmut Schmidt, Gunter Betzien
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Patent number: 3966916Abstract: New N(6)-disubstituted adenosine compound of the formula ##SPC1##WhereinR.sub.1 is lower alkyl substituted by at least one of hydroxyl, alkoxy or acyloxy; or is cycloalkyl or straight-chained or branched lower alkenyl;R.sub.2 and R.sub.3 are hydrogen, halogen, or nitro or lower alkyl, alkoxy or alkylthio andR.sub.4 is hydrogen or acyl; when R.sub.4 is acyl, R.sub.1 can also be lower alkyl;And the pharmacologicaly compatible salts thereof; exhibits shown anti-lipolytic, anti-hyperlipaemic and anti-hypercholesterolaemic action.Type: GrantFiled: November 21, 1974Date of Patent: June 29, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Wolfgang Kampe, Erich Fauland, Kurt Stach, Harald Stork, Felix Helmut Schmidt