Patents by Inventor Felix Karim

Felix Karim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nadks as Modifiers of Branching Morphogenesis and Methods of Use
    Publication number: 20070269378
    Abstract: Human NADK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morpho-genesis, comprising screening for agents that modulate the activity of NADK are provided.
    Type: Application
    Filed: June 18, 2004
    Publication date: November 22, 2007
    Applicant: EXELIXIS INC.
    Inventors: Gregory Plowman, Felix Karim, Candace Swimmer, Hinrich Habeck, Thomas Koblizek, Stefan Schulte-Merker, Ulrike Eisenmann, Gordon Stott, Torsten Trowe, Andreas Vogel, Joerg Odenthal, Jochen Scheel, Torsten Will, Yinsheng Jin, Lynn Bjerke, Timothy Heuer
  • Mapk7 as modifier of branching morphogenesis and methods of use
    Publication number: 20070003927
    Abstract: Human MAPK7 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAPK7 are provided.
    Type: Application
    Filed: October 22, 2003
    Publication date: January 4, 2007
    Inventors: Gregory Plowman, Felix Karim, Candace Swimmer, Hinrich Habeck, Thomas Koblizek, Stefan Schulte-Merker, Ulrike Langheinrich, Gordon Stott, Torsten Trowe, Andreas Vogel, Joerg Heinrich, Jochen Scheel, Torsten Will, Yisheng Jin, Joanne Adamkewicz
  • Cdkl 1 as modifier of branching morphogenesis and methods of use
    Publication number: 20060257870
    Abstract: Human CDKL1 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CDKL1 are provided.
    Type: Application
    Filed: October 22, 2003
    Publication date: November 16, 2006
    Inventors: Gregory Plowman, Felix Karim, Candace Swimmer, Hinrich Habeck, Thomas Koblizek, Stefan Schulte-Merker, Ulrike Langheinrich, Gordon Stott, Torsten Trowe, Andreas Vogel, Joerg Odenthal, Jochen Scheel, Torsten Will, Yisheng Jin, Bing Hai
  • Protein kinase required for Ras signal transduction
    Patent number: 5747288
    Abstract: The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: May 5, 1998
    Assignee: The Regents of the University of California
    Inventors: Gerry Rubin, Marc Therrien, Henry Chang, Felix Karim, David Wassarman
  • Protein kinase required for RAS signal transduction
    Patent number: 5747275
    Abstract: The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: May 5, 1998
    Assignee: The Regents of the University of California
    Inventors: Gerry Rubin, Marc Therrien, Henry Chang, Felix Karim, David Wassarman
  • Protein kinase required for Ras signal transduction
    Patent number: 5700675
    Abstract: The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.
    Type: Grant
    Filed: December 13, 1995
    Date of Patent: December 23, 1997
    Assignee: Regents of the University of California
    Inventors: Gerry Rubin, Marc Therrien, Henry Chang, Felix Karim, David Wassarman