Patents by Inventor Felix Theeuwes

Felix Theeuwes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space
    Publication number: 20030009145
    Abstract: The present invention provides delivery of drugs to the heart or cardiac vasculature using fully implanted sustained-release dosage forms.
    Type: Application
    Filed: March 22, 2002
    Publication date: January 9, 2003
    Inventors: Harry A.J. Struijker-Boudier, Johannes J.R. Hermans, Jos F.M. Smits, Randolph M. Johnson, Felix Theeuwes
  • Regulation of drug delivery through flow diversion
    Publication number: 20020193751
    Abstract: The present invention features methods and devices for modulating the rate of delivery of a drug formulation from a drug delivery device by diverting drug away from a drug delivery pathway. In one embodiment, a flow regulator is positioned relative to a drug delivery pathway of a drug delivery system so that adjustment of the flow regulator can provide for diversion of drug away from the drug delivery pathway. Diverted drug can be either delivered into the systemic circulation of the subject, or can be captured in a waste reservoir.
    Type: Application
    Filed: April 2, 2002
    Publication date: December 19, 2002
    Inventors: Felix Theeuwes, James E. Brown, Timothy Scott Nelson
  • Composite drug delivery catheter
    Publication number: 20020095133
    Abstract: The present invention features a composite catheter comprising an elongate outer member and an elongate inner member positioned within the outer member so that the inner and outer members define an interstitial space. The outer member has a size and other characteristics that facilitate handling and implantation of the composite catheter, while the inner diameter of the inner member has the size and other characteristics suitable for delivery of a drug through a lumen of the inner member. The interstitial space imparts flexibility to the composite catheter by, for example, removing material from the cross-sectional area that would otherwise provide additional stiffness to the catheter, and/or by accommodating movement of the outer member relative to the inner member.
    Type: Application
    Filed: January 28, 2002
    Publication date: July 18, 2002
    Inventors: Edward M. Gillis, Felix Theeuwes
  • Device and method for enhancing transdermal flux of agents being sampled
    Publication number: 20020077584
    Abstract: A transdermal agent sampling device is provided. The sampling device is comprised of a microblade array and a device for applying a partial vacuum. The microblade array comprises a sheet having a plurality of microblades for piercing the skin to a very shallow depth (i.e., 25 &mgr;m to 400 &mgr;m) to create microslits in the outermost stratum corneum layer of the skin. The partial vacuum applying device applies a partial vacuum in the range of about 0.1 to about 0.8 atm, and preferably about 0.3 to about 0.7 atm, for sampling a body analyte such as glucose in interstitial fluid. The partial vacuum is applied for a period of about 2 to about 30 seconds, and preferably about 5 to about 15 seconds. The interstial fluid is analyzed for body analyte (e.g., glucose) content or concentration.
    Type: Application
    Filed: December 14, 2000
    Publication date: June 20, 2002
    Inventors: Wei-Qi Lin, Michel J.N. Cormier, Felix Theeuwes
  • Composite drug delivery catheter
    Patent number: 6368315
    Abstract: The present invention features a composite catheter comprising an elongate outer member and an elongate inner member positioned within the outer member so that the inner and outer members define an interstitial space. The outer member has a size and other characteristics that facilitate handling and implantation of the composite catheter, while the inner diameter of the inner member has the size and other characteristics suitable for delivery of a drug through a lumen of the inner member. The interstitial space imparts flexibility to the composite catheter by, for example, removing material from the cross-sectional area that would otherwise provide additional stiffness to the catheter, and/or by accommodating movement of the outer member relative to the inner member.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: April 9, 2002
    Assignee: Durect Corporation
    Inventors: Edward M. Gillis, Felix Theeuwes
  • IMPLANTABLE DEVICE FOR ACCESS TO A TREATMENT SITE
    Publication number: 20010041870
    Abstract: The present invention provides an implantable guide for access to a treatment site. The implantable guide comprises a proximal end, a distal end, and a guide body defining a lumen, and can optionally comprise a stable positioning element for stably positioning a drug delivery device within the guide. The guide can be provided in connection with a drug delivery device. In use, the guide is implanted within a subject so as to provide a conduit through which a drug delivery device can be retrievably introduced to facilitate delivery of drug to a treatment site within a subject at a site distal to an accessible implantation site. The drug delivery device is then positioned within the guide lumen to provide for delivery of drug from the drug delivery to the desired treatment site.
    Type: Application
    Filed: March 31, 1999
    Publication date: November 15, 2001
    Inventors: EDWARD M. GILLIS, FELIX THEEUWES
  • Electrotransport system with ion exchange material competitive ion capture
    Patent number: 6289242
    Abstract: An electrotransport apparatus using dispersed ion exchange material (19,83) is disclosed. The ion exchange material (19,83) may be dispersed in either the donor electrode assembly (10), the counter electrode assembly (10) or both electrode assemblies. The dispersed ion exchange material (83) comprises mobile ionic species (84-2) and substantially immobile ionic species (P). The dispersed ion exchange material (83, 84-2) interacts with competitive species (86) generated during electrotransport to render those species substantially immobile (87). Electrotransport devices exhibiting reduced polarization are also disclosed.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: September 11, 2001
    Assignee: Alza Corporation
    Inventors: J. Bradley Phipps, Lyn C. Moodie, J. Richard Gyory, Felix Theeuwes
  • Dosage form comprising a capsule
    Patent number: 6183466
    Abstract: A dosage form is disclosed comprising a wall that defines an injection-molded compartment housing a capsule comprising a drug formulation.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: February 6, 2001
    Assignee: Alza Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes, Vincent J. Ferrari, Liang C. Dong
  • Prolonged release active agent dosage form adapted for gastric retention
    Patent number: 6120803
    Abstract: The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
    Type: Grant
    Filed: August 10, 1998
    Date of Patent: September 19, 2000
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Liang-Chang Dong, David E. Edgren, Felix Theeuwes, Phyllis I. Gardner, Francisco Jao, Jason J. Wan
  • Electrotransport system with ion exchange material competitive ion capture
    Patent number: 6049733
    Abstract: An electrotransport apparatus using dispersed ion exchange material (19,83) is disclosed. The ion exchange material (19,83) may be dispersed in either the donor electrode assembly (10), the counter electrode assembly (10) or both electrode assemblies. The dispersed ion exchange material (83) comprises mobile ionic species (84-2) and substantially immobile ionic species (P). The dispersed ion exchange material (83, 84-2) interacts with competitive species (86) generated during electrotransport to render those species substantially immobile (87). Electrotransport devices exhibiting reduced polarization are also disclosed.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: April 11, 2000
    Assignee: ALZA Corporation
    Inventors: J. Bradley Phipps, Lyn C. Moodie, J. Richard Gyory, Felix Theeuwes
  • Device and method of iontophoretic drug delivery
    Patent number: 5993435
    Abstract: A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: November 30, 1999
    Assignee: ALZA Corporation
    Inventors: Ronald P. Haak, J. Richard Gyory, Felix Theeuwes
  • Electrotransport agent delivery method and apparatus
    Patent number: 5983130
    Abstract: An electrotransport agent delivery device for delivering a therapeutic agent through a body surface, and a method for increasing agent delivery efficiency, is provided. The device includes a current controller which delivers a pulsating electrotransport current and peak current density I.sub.max, I.sub.max being greater than a critical current density level I.sub.c above which the body exhibits a non-transitory higher agent delivery efficiency. Methods for increasing electrotransport delivery efficiency (E) of an agent through a body surface by creation of a higher agent delivery efficiency state are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 9, 1999
    Assignee: Alza Corporation
    Inventors: J. Bradley Phipps, Gary A. Lattin, Ronald P. Haak, Suneel Gupta, Felix Theeuwes
  • Osmotic device for delayed delivery of agent
    Patent number: 5938654
    Abstract: A dispenser for use in a fluid environment of use which is capable of the delivery of one or a plurality of discrete active agent-containing units in any desired delivery pattern or profile. It also can provide for the initially delayed delivery of an active agent to the environment of use and for high accuracy in the timing of delivery of the active agent.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: August 17, 1999
    Assignee: Alza Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, James B. Eckenhoff, Steven D. Larsen, Hoa T. Huynh
  • Electrotransport system with ion exchange material providing enhanced drug delivery
    Patent number: 5871460
    Abstract: An electrotransport apparatus using dispersed ion exchange material (19,93) is disclosed. The ion exchange material (19,93) may be dispersed in either the donor electrode assembly (10), the counter electrode assembly (10) or both electrode assemblies. The dispersed ion exchange material (93) comprises mobile ionic species (C2) and substantially immobile ionic species (P). The dispersed ion exchange material (93) is consumed during electrotransport of drug or agent (A) in an electrotransport process in which substantially no species which compete with the drug or agent for electrotransport are generated. Electrotransport devices exhibiting reduced polarization are also disclosed.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: February 16, 1999
    Assignee: ALZA Corporation
    Inventors: J. Bradley Phipps, Lyn C. Moodie, J. Richard Gyory, Felix Theeuwes
  • Method of therapy comprising an osmotic caplet
    Patent number: 5869097
    Abstract: An osmotic caplet is disclosed comprising an osmotic caplet exit for delivering a preselected dose of drug to a patient in need of therapy.
    Type: Grant
    Filed: November 2, 1992
    Date of Patent: February 9, 1999
    Assignee: Alza Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, George V. Guittard, Atul D. Ayer
  • Device and method of iontophoretic drug delivery
    Patent number: 5857992
    Abstract: A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: January 12, 1999
    Assignee: ALZA Corporation
    Inventors: Ronald P. Haak, J. Richard Gyory, Felix Theeuwes
  • Osmotic drug delivery devices with hydrophobic wall materials
    Patent number: 5795591
    Abstract: Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of osmotically active species in the interior of the device, despite pores which by their hydrophobic character do not permit the passage of liquid water, and despite the absence of a cellulosic semi-permeable membrane, the devices absorb water by osmosis without loss of the osmotically active species, and function in a manner analogous to osmotic pumps of the prior art. By permitting the use of hydrophobic substances as the wall material, the invention permits the device to be constructed entirely from biodegradable materials.
    Type: Grant
    Filed: September 1, 1994
    Date of Patent: August 18, 1998
    Assignee: ALZA Corporation
    Inventors: Eun Soo Lee, Scott A. Bura, Su Il Yum, Patrick S.-L. Wong, Felix Theeuwes
  • Method for administering drug to gastrointestinal tract
    Patent number: 5785994
    Abstract: A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: July 28, 1998
    Assignee: ALZA Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, Atul Devdatt Ayer, Anthony L. Kuczynski
  • Device and method of iontophoretic drug delivery
    Patent number: 5647844
    Abstract: A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: July 15, 1997
    Assignee: ALZA Corporation
    Inventors: Ronald P. Haak, J. Richard Gyory, Felix Theeuwes
  • Osmotic device for delayed delivery of agent
    Patent number: 5531736
    Abstract: The present invention is directed to a fluid-imbibing dispensing device for the initially delayed delivery of an active agent to a fluid environment of use and to a method of using the dispensing device. The dispenser comprises a housing having a first wall section and a second wall section in reversibly sliding telescopic arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; at least one active agent formulation in the compartment; and expansion means and a push plate in the compartment for separating apart the first and second wall sections of the housing after exposure to the environment of use to expose the active agent formulation to the environment of use.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: July 2, 1996
    Assignee: Alza Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, Steven D. Larsen, Liang C. Dong