Patents by Inventor Felix Von Stetten
Felix Von Stetten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230407376Abstract: The present invention concerns a mediator probe for the detection of at least one target molecule comprising at least two oligonucleotides. A first oligonucleotide of the mediator probe according to the invention comprises a probe region and a mediator binding region, wherein the probe region has an affinity to a target molecule and/or template molecule, and the mediator binding region has an affinity to at least one mediator. At least one further oligonucleotide of the mediator probe is a mediator which is bound to the first oligonucleotide of the mediator probe via the mediator binding region and has an affinity for at least one detection molecule, wherein the mediator triggers a detectable signal by interaction with the detection molecule after release from the first oligonucleotide of the mediator probe.Type: ApplicationFiled: February 24, 2023Publication date: December 21, 2023Applicants: Albert-Ludwigs-Universitat Freiburg, Hahn-Schickard-Gesellschaft Fur Angewandte Forschung E.V.Inventors: Martin Trotter, Simon Wadle, Felix Von Stetten, Lisa Becherer
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Patent number: 11293053Abstract: The invention relates to a mediator probe comprising a probe region and a mediator region. Furthermore, the invention relates to a system comprising a mediator probe and a detection molecule, use of that system and a method for detection of at least one target molecule.Type: GrantFiled: November 12, 2012Date of Patent: April 5, 2022Assignee: ALBERT-LUDWIGS-UNIVERSITAET FREIBURGInventors: Guenter Roth, Bernd Faltin, Felix Von Stetten, Simon Wadle
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Publication number: 20210340606Abstract: A method of producing a replicate or derivative of an array of molecules, the array having a spatial arrangement of separate samples of molecules, includes creating, for each sample, at least one spatially limited effective area which is separate from the effective areas of the other samples, a surface, provided with a binding adapter or binding properties, of a carrier bordering on the effective areas. The molecules are amplified by means of amplifying agents in the effective areas for creating replicates or derivatives of the samples. The replicates or derivatives of the samples are bound to the carrier by means of the binding adapter or the binding properties, so that a spatial arrangement of the replicates or derivatives of the samples on the carrier corresponds to the spatial arrangement of the samples in the array. The carrier having the copies of the samples is removed from the array.Type: ApplicationFiled: May 28, 2021Publication date: November 4, 2021Inventors: Roland ZENGERLE, Felix von Stetten, Guenter Roth, Jochen Hoffmann
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Patent number: 10773257Abstract: A device for stirring at least one liquid includes a fluidics module rotatable about an axis of rotation, a liquid chamber for the liquid within the fluidics module, an introducer for introducing mutually separate phase volumes of a phase different from the liquid, said phase volumes having a different density than the liquid, into the liquid within the liquid chamber, and a driving device for subjecting the fluidics module to such a rotation that the phase volumes are moved radially inward or outward in relation to the axis of rotation through the liquid due to the different density of the phase volumes and of the liquid and due to the centrifugal forces caused by the rotation.Type: GrantFiled: April 6, 2016Date of Patent: September 15, 2020Assignee: Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V.Inventors: Nils Paust, Arne Kloke, Felix Von Stetten, Jens Liebeskind
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Patent number: 10563656Abstract: A fluidics module rotatable about a rotational center includes first and second chambers and a compression chamber. First and second fluid channels are provided between the first and second chambers and the compression chamber, respectively. The flow resistance of the second fluid channel is smaller, for a flow of liquid from the compression chamber to the second chamber, than a flow resistance of the first fluid channel for a flow of liquid from the compression chamber to the first chamber. Upon rotation at a high rotational frequency, liquid is initially introduced from the first chamber into the compression chamber via the first fluid channel, so that a compressible medium is compressed within the compression chamber. Subsequently, the rotational frequency is reduced, so that the compressible medium within the compression chamber will expand and so that, thereby, liquid is driven into the second chamber via the second fluid channel.Type: GrantFiled: June 15, 2018Date of Patent: February 18, 2020Assignee: HAHN-SCHICKARD-GESELLSCHAFT FÜR ANGEWANDTE FORSCHUNG E.V.Inventors: Nils Paust, Steffen Zehnle, Felix Von Stetten
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Publication number: 20190376126Abstract: The present invention concerns a mediator probe for the detection of at least one target molecule comprising at least two oligonucleotides. A first oligonucleotide of the mediator probe according to the invention comprises a probe region and a mediator binding region, wherein the probe region has an affinity to a target molecule and/or template molecule, and the mediator binding region has an affinity to at least one mediator. At least one further oligonucleotide of the mediator probe is a mediator which is bound to the first oligonucleotide of the mediator probe via the mediator binding region and has an affinity for at least one detection molecule, wherein the mediator triggers a detectable signal by interaction with the detection molecule after release from the first oligonucleotide of the mediator probe.Type: ApplicationFiled: December 15, 2017Publication date: December 12, 2019Inventors: Martin TROTTER, Simon WADLE, Felix VON STETTEN, Lisa BECHERER
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Publication number: 20180291912Abstract: A fluidics module rotatable about a rotational center includes first and second chambers and a compression chamber. First and second fluid channels are provided between the first and second chambers and the compression chamber, respectively. The flow resistance of the second fluid channel is smaller, for a flow of liquid from the compression chamber to the second chamber, than a flow resistance of the first fluid channel for a flow of liquid from the compression chamber to the first chamber. Upon rotation at a high rotational frequency, liquid is initially introduced from the first chamber into the compression chamber via the first fluid channel, so that a compressible medium is compressed within the compression chamber. Subsequently, the rotational frequency is reduced, so that the compressible medium within the compression chamber will expand and so that, thereby, liquid is driven into the second chamber via the second fluid channel.Type: ApplicationFiled: June 15, 2018Publication date: October 11, 2018Inventors: Nils PAUST, Steffen ZEHNLE, Felix VON STETTEN
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Patent number: 10001125Abstract: A fluidics module rotatable about a rotational center includes first and second chambers and a compression chamber. First and second fluid channels are provided between the first and second chambers and the compression chamber, respectively. The flow resistance of the second fluid channel is smaller, for a flow of liquid from the compression chamber to the second chamber, than a flow resistance of the first fluid channel for a flow of liquid from the compression chamber to the first chamber. Upon rotation at a high rotational frequency, liquid is initially introduced from the first chamber into the compression chamber via the first fluid channel, so that a compressible medium is compressed within the compression chamber. Subsequently, the rotational frequency is reduced, so that the compressible medium within the compression chamber will expand and so that, thereby, liquid is driven into the second chamber via the second fluid channel.Type: GrantFiled: August 14, 2014Date of Patent: June 19, 2018Assignee: HAHN-SCHICKARD-GESELLSCHAFT FÜR ANGEWANDTE FORSCHUNG E.V.Inventors: Nils Paust, Steffen Zehnle, Felix Von Stetten
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Publication number: 20170369938Abstract: A method of producing a replicate or derivative of an array of molecules, the array having a spatial arrangement of separate samples of molecules, includes creating, for each sample, at least one spatially limited effective area which is separate from the effective areas of the other samples, a surface, provided with a binding adapter or binding properties, of a carrier bordering on the effective areas. The molecules are amplified by means of amplifying agents in the effective areas for creating replicates or derivatives of the samples. The replicates or derivatives of the samples are bound to the carrier by means of the binding adapter or the binding properties, so that a spatial arrangement of the replicates or derivatives of the samples on the carrier corresponds to the spatial arrangement of the samples in the array. The carrier having the copies of the samples is removed from the array.Type: ApplicationFiled: July 4, 2017Publication date: December 28, 2017Inventors: Roland ZENGERLE, Felix von Stetten, Guenter Roth, Jochen Hoffmann
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Publication number: 20170322204Abstract: The present invention provides methods, immunoassays, kits and devices pertaining to the detection of multiple biomolecules from single cells or other biological entities. It also enables the highly parallel detection of interacting biomolecules from such entities.Type: ApplicationFiled: July 26, 2017Publication date: November 9, 2017Inventors: Markus Enzelberger, Andreas Boll, Beate Diefenbach-Streiber, Guenter Roth, Felix von Stetten, Fabian Stumpf
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Patent number: 9725758Abstract: A method of producing a replicate or derivative of an array of molecules, the array having a spatial arrangement of separate samples of molecules, includes creating, for each sample, at least one spatially limited effective area which is separate from the effective areas of the other samples, a surface, provided with a binding adapter or binding properties, of a carrier bordering on the effective areas. The molecules are amplified by means of amplifying agents in the effective areas for creating replicates or derivatives of the samples. The replicates or derivatives of the samples are bound to the carrier by means of the binding adapter or the binding properties, so that a spatial arrangement of the replicates or derivatives of the samples on the carrier corresponds to the spatial arrangement of the samples in the array. The carrier having the copies of the samples is removed from the array.Type: GrantFiled: September 2, 2011Date of Patent: August 8, 2017Assignee: ALBERT-LUDWIGS-UNIVERSITAET FREIBURGInventors: Roland Zengerle, Felix Von Stetten, Guenter Roth, Jochen Hoffmann
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Patent number: 9616397Abstract: A mixer for insertion into a rotor of a centrifuge has a mixing trough and an obstacle device with at least one obstacle. The at least one obstacle is configured in order to influence the flow of a liquid present in the mixing trough. In response to a rotation of the rotor, with a specified incorporation of the mixer in a holder of the rotor, a spacing between at least one wall section of the mixing trough and the obstacle device is variable such that the liquid present in the mixing trough flows around the obstacle of the obstacle device.Type: GrantFiled: May 27, 2014Date of Patent: April 11, 2017Assignee: Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V.Inventors: Nils Paust, Felix Von Stetten
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Patent number: 9457359Abstract: A device for insertion into a rotor of a centrifuge has at least two bodies stacked one above the other in a stacking direction inside a housing insertable into a holder of the rotor of the centrifuge. The two bodies are movably disposed in relation to each other inside the housing in order to fluidically couple, in a first phase, responding to a rotation of the rotor, a first cavity of the first body to a first cavity of the second body and to fluidically couple in a second phase a second cavity of the first body to the first cavity of the second body.Type: GrantFiled: September 21, 2012Date of Patent: October 4, 2016Assignees: ALBERT-LUDWIGS-UNIVERSITAET FREIBURG, HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHInventors: Felix Von Stetten, Marion Finkbeiner, Roland Zengerle, Nils Paust, Guenter Roth
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Publication number: 20160214105Abstract: A device for stirring at least one liquid includes a fluidics module rotatable about an axis of rotation, a liquid chamber for the liquid within the fluidics module, an introducer for introducing mutually separate phase volumes of a phase different from the liquid, said phase volumes having a different density than the liquid, into the liquid within the liquid chamber, and a driving device for subjecting the fluidics module to such a rotation that the phase volumes are moved radially inward or outward in relation to the axis of rotation through the liquid due to the different density of the phase volumes and of the liquid and due to the centrifugal forces caused by the rotation.Type: ApplicationFiled: April 6, 2016Publication date: July 28, 2016Inventors: Nils PAUST, Arne KLOKE, Felix VON STETTEN, Jens LIEBESKIND
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Publication number: 20150190816Abstract: A revolver component for a reagent vessel for a centrifuge and/or for a pressure-varying device includes a revolver housing which is able to be installed in the reagent vessel. Provided on the revolver housing is a guide structure, which is able to be contacted using at least one elevation provided on one reagent vessel part of the reagent vessel or provided on a further revolver component. The guide structure is developed in such a way that the revolver housing is able to be adjusted, with respect to the at least contacted reagent vessel part or with respect to the further revolver component into a first submotion along an axis and into a second submotion about the axis.Type: ApplicationFiled: July 10, 2013Publication date: July 9, 2015Inventors: Nils Paust, Felix von Stetten, Juergen Steigert, Arne Kloke, Guenter Roth, Martina Daub
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Publication number: 20150094196Abstract: A revolver component for a reagent vessel has at least one first chamber that is configured to be filled at least partly with at least one liquid. The first chamber is formed or fitted such that a first chamber filling volume that is configured to be filled with the at least one liquid is delimited by an expansion-variable boundary. The expansion-variable boundary has a spatial expansion that can be reversibly adjusted such that the filling volume is configured to be varied. Reagent vessel insert parts and reagent vessels are also disclosed. Methods for centrifuging a material and for pressure treating a material are also disclosed.Type: ApplicationFiled: February 21, 2013Publication date: April 2, 2015Inventors: Martina Daub, Guenter Roth, Arne Kloke, Nils Paust, Juergen Steigert, Felix von Stetten
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Patent number: 8951417Abstract: A method of transporting magnetic particles enables magnetic particles to be transported between a plurality of microfluidic chambers which are connected to one another via a fluidic connection on a radially inner side, and are fluidically separated from one another on a radially outer side. Magnetic forces and centrifugal forces are exploited to transport magnetic particles from one chamber to another across phase boundaries.Type: GrantFiled: March 28, 2013Date of Patent: February 10, 2015Assignee: Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.VInventors: Oliver Strohmeier, Felix Von Stetten, Daniel Mark
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Publication number: 20140356129Abstract: A fluidics module rotatable about a rotational center includes first and second chambers and a compression chamber. First and second fluid channels are provided between the first and second chambers and the compression chamber, respectively. The flow resistance of the second fluid channel is smaller, for a flow of liquid from the compression chamber to the second chamber, than a flow resistance of the first fluid channel for a flow of liquid from the compression chamber to the first chamber. Upon rotation at a high rotational frequency, liquid is initially introduced from the first chamber into the compression chamber via the first fluid channel, so that a compressible medium is compressed within the compression chamber. Subsequently, the rotational frequency is reduced, so that the compressible medium within the compression chamber will expand and so that, thereby, liquid is driven into the second chamber via the second fluid channel.Type: ApplicationFiled: August 14, 2014Publication date: December 4, 2014Inventors: Nils PAUST, Steffen ZEHNLE, Felix VON STETTEN
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Publication number: 20140315747Abstract: The invention relates to a mediator probe comprising a probe region and a mediator region. Furthermore, the invention relates to a system comprising a mediator probe and a detection molecule, use of that system and a method for detection of at least one target molecule.Type: ApplicationFiled: November 12, 2012Publication date: October 23, 2014Inventors: Guenter Roth, Bernd Faltin, Felix Von Stetten, Simon Wadle
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Publication number: 20140251886Abstract: A mixer for insertion into a rotor of a centrifuge has a mixing trough and an obstacle device with at least one obstacle. The at least one obstacle is configured in order to influence the flow of a liquid present in the mixing trough. In response to a rotation of the rotor, with a specified incorporation of the mixer in a holder of the rotor, a spacing between at least one wall section of the mixing trough and the obstacle device is variable such that the liquid present in the mixing trough flows around the obstacle of the obstacle device.Type: ApplicationFiled: May 27, 2014Publication date: September 11, 2014Applicant: Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V.Inventors: Nils PAUST, Felix VON STETTEN