Abstract: A pipettor uses no pistons in order to provide highly automated, precise and accurate pipetting operations. Additionally, a self-aligning pipette tip enables better engagement of such pipette tips by the pipettor. The pipette tips may be automatically engaged and locked into place by the pipettor and may be automatically disengaged to enable highly-automated pipetting processes for industrial and laboratory purposes. Open proximal ends of the pipette tips are engaged by a pipette block, which then forms a temporary seal with the individual pipette tips. Displacement of the pipette block with respect to the pipette tips increased or decreases the effective volume of the pipette tip allowing it to aspirate or expel fluids in a precise, accurate, and predictable way.