Patents by Inventor FEMKE KARINA DE THEIJE
FEMKE KARINA DE THEIJE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11402374Abstract: The invention relates to a method for the detection of target components that comprise label particles, for example magnetic particles (1). The method includes (a) collecting the target components at a binding surface (12, 112, 512) of a carrier (11, 111, 211, 311, 411, 511); (b) directing an input light beam (L1, L1a, L1b) into the carrier such that it is totally internally reflected in an investigation region (13, 313a, 313b) at the binding surface (12, 112, 512); and (c) determining the amount of light of an output light beam (L2, L2a, L2b) that comprises at least some of the totally internally reflected light. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b).Type: GrantFiled: May 8, 2015Date of Patent: August 2, 2022Assignee: Siemens Healthineers Nederland B.V.Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina De Theije, Thea van der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Patent number: 11243199Abstract: The invention relates to a carrier with a binding surface at which target components that comprise label particles, for example magnetic particles, can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles at the binding surface and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface from the amount of light in the output light beam (L2, L2a, L2b).Type: GrantFiled: April 15, 2015Date of Patent: February 8, 2022Assignee: Siemens Healthineers Nederland B.V.Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina De Theije e/v Wijgergangs, Thea van der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Patent number: 10591472Abstract: The present invention relates to a method for detection of at least one target molecule in a blood sample comprising at least the following steps: (a) providing a blood sample; (b1) contacting said sample with an antioxidant and applying said sample to a filter to separate the blood cells from said sample; and/or (b2) applying said sample to a filter to separate the blood cells from said sample, wherein said filter comprises an antioxidant; (c) contacting said sample with a first binding molecule in the cartridge, wherein said first binding molecule is attached to a magnetic particle, and wherein said first binding molecule is capable of specifically binding to said at least one target molecule; (d) contacting said sample with a second binding molecule, wherein said second binding molecule is attached to a sensor surface, and wherein said second binding molecule is capable of specifically binding to said at least one target molecule; and (e) detecting the magnetic particles on the sensor surface.Type: GrantFiled: August 8, 2013Date of Patent: March 17, 2020Assignee: Minicare B.V.Inventors: Femke Karina De Theije, Joost Lambert Max Vissers
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Patent number: 10031132Abstract: The invention relates to a method and a device for the detection of magnetic particles (1) in a sample chamber (112). After introduction of the sample into said sample chamber (112), the magnetic particles (1) are first retained within the sample chamber (112) and kept away from the sensing surface (111) by an appropriate magnetic field (B) to allow for an incubation of the sample with reagents. A reference measurement may be made during this incubation period (TI), preferably at the end thereof. After incubation, the magnetic particles (1) are allowed to contact the sensing surface (111) where a target measurement can be conducted.Type: GrantFiled: October 5, 2012Date of Patent: July 24, 2018Assignee: Minicare B.V.Inventors: Sytske Foppen, Bernardus Jozef Maria Beerling, Willemina Maria Huijnen-Keur, Hendrik Jan De Graaf, Danielle Walthera Maria Kemper-Van De Wiel, Roland Antonius Johannes Gerardus Smits, Albert Hendrik Jan Immink, Femke Karina De Theije, Wendela Meertens
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Patent number: 10006907Abstract: A cartridge for detection of target components in a liquid sample includes a sample chamber, at least two reservoirs that can be furnished with magnetic particles, and at least two corresponding sensitive zones in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.Type: GrantFiled: June 16, 2016Date of Patent: June 26, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Mara Johanna Jacoba Sijbers, Petrus Johannes Wilhelmus Van Lankvelt, Femke Karina De Theije, Jeroen Hans Nieuwenhuis
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Patent number: 9778254Abstract: A system and method wherein components of a reagent such as labeled antibodies are separated from a biologically active sensor surface by depositing the reagent on a carrier surface distinct from a sensor surface in a detection region. The present device provides a short, well-defined and controlled, pre-incubation time between the particles of interest in the sample fluid and the reagent, thereby increasing the reproducibility by providing all components in one detection region such as a detection chamber.Type: GrantFiled: July 18, 2008Date of Patent: October 3, 2017Assignees: KONINKLIJKE PHILIPS N.V., CONCATENO UK LIMITEDInventors: Femke Karina De Theije, Thea Van Der Wijk, Albert Hendrik Jan Immink, Eduard Gerard Marie Pelssers, Wilhelmina Maria Hardeman, Sandra Marlin, Gordon Thomas Jowett
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Patent number: 9658219Abstract: A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.Type: GrantFiled: December 10, 2007Date of Patent: May 23, 2017Assignee: Koninklijke Philips N.V.Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina De Theije, Thea Van Der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Patent number: 9575081Abstract: The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the presence of one or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one or more analytes and/or analyte analogues.Type: GrantFiled: February 26, 2014Date of Patent: February 21, 2017Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Jeroen Hans Nieuwenhuis, Ahmed Mohammed Taki Jehanli, Femke Karina De Theije, Eduard Gerard Marie Pelssers
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Patent number: 9557328Abstract: A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40?).Type: GrantFiled: June 24, 2010Date of Patent: January 31, 2017Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Wendy Uyen Dittmer, Femke Karina De Theije, Albert Hendrik Jan Immink, Jeroen Hans Nieuwenhuis, Petrus Johannes Wilhelmus Van Lankvelt
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Publication number: 20160291004Abstract: A cartridge for detection of target components in a liquid sample includes a sample chamber, at least two reservoirs that can be furnished with magnetic particles, and at least two corresponding sensitive zones in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.Type: ApplicationFiled: June 16, 2016Publication date: October 6, 2016Inventors: Mara Johanna Jacoba Sijbers, Petrus Johannes Wilhelmus Van Lankvelt, Femke Karina De Theije, Jeroen Hans Nieuwenhuis
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Publication number: 20150241416Abstract: The invention relates to a method for the detection of target components that comprise label particles, for example magnetic particles (1). The method includes (a) collecting the target components at a binding surface (12, 112, 512) of a carrier (11, 111, 211, 311, 411, 511); (b) directing an input light beam (L1, L1a, L1b) into the carrier such that it is totally internally reflected in an investigation region (13, 313a, 313b) at the binding surface (12, 112, 512); and (c) determining the amount of light of an output light beam (L2, L2a, L2b) that comprises at least some of the totally internally reflected light. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b).Type: ApplicationFiled: May 8, 2015Publication date: August 27, 2015Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina DE THEIJE e/v WIJGERGANGS, Thea van der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Publication number: 20150226732Abstract: The present invention relates to a method for detection of at least one target molecule in a blood sample comprising at least the following steps:(a) providing a blood sample; (b1) contacting said sample with an antioxidant and applying said sample to a filter to separate the blood cells from said sample; and/or (b2) applying said sample to a filter to separate the blood cells from said sample, wherein said filter comprises an antioxidant; (c) contacting said sample with a first binding molecule in the cartridge, wherein said first binding molecule is attached to a magnetic particle, and wherein said first binding molecule is capable of specifically binding to said at least one target molecule; (d) contacting said sample with a second binding molecule, wherein said second binding molecule is attached to a sensor surface, and wherein said second binding molecule is capable of specifically binding to said at least one target molecule; and (e) detecting the magnetic particles on the sensor surface.Type: ApplicationFiled: August 8, 2013Publication date: August 13, 2015Inventors: Femke Karina De Theije, Joost Lambert Max Vissers
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Publication number: 20150226733Abstract: The invention relates to a carrier with a binding surface at which target components that comprise label particles, for example magnetic particles, can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles at the binding surface and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface from the amount of light in the output light beam (L2, L2a, L2b).Type: ApplicationFiled: April 15, 2015Publication date: August 13, 2015Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina DE THEIJE e/v WIJGERGANGS, Thea van der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Patent number: 9103843Abstract: The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the presence of one or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one or more analytes and/or analyte analogs.Type: GrantFiled: May 26, 2009Date of Patent: August 11, 2015Assignee: Koninklijke Philips N.V.Inventors: Jeroen Hans Nieuwenhuis, Ahmed Mohammed Taki Jehanli, Femke Karina De Theije, Eduard Gerard Marie Pelssers
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Publication number: 20140329335Abstract: The invention relates to a method and a device for the detection of magnetic particles (1) in a sample chamber (112). After introduction of the sample into said sample chamber (112), the magnetic particles (1) are first retained within the sample chamber (112) and kept away from the sensing surface (111) by an appropriate magnetic field (B) to allow for an incubation of the sample with reagents. A reference measurement may be made during this incubation period (TI), preferably at the end thereof. After incubation, the magnetic particles (1) are allowed to contact the sensing surface (111) where a target measurement can be conducted.Type: ApplicationFiled: October 5, 2012Publication date: November 6, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Sytske Foppen, Bernardus Jozef Maria Beerling, Willemina Maria Huijnen-Keur, Hendrik Jan De Graaf, Danielle Walthera Maria Kemper-Van De Wiel, Roland Antonius Johannes Gerardus Smits, Albert Hendrik Jan Immink, Femke Karina De Theije, Wendela Meertens
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Publication number: 20140323856Abstract: A system for providing sensory feedback includes a garment (106) that is configured to flexibly and snuggly fit over a portion of a subject. The garment includes one or more sensors (104) disposed therein to monitor activity of the subject or monitor points of interest of the subject. An interpretation module (115) is coupled with the sensors to receive sensor signals and interpret the sensor signals to determine if conditions are met to provide feedback signals to the garment. A feedback modality (108) is incorporated into the garment and is responsive to the feedback signals such that the feedback modality emits energy from the garment to provide sensory information to assist a physician during a procedure.Type: ApplicationFiled: October 19, 2012Publication date: October 30, 2014Inventors: Sytske Foppen, Bernardus Jozef Maria Beerling, Willemina Maria Huijnen-Keur, Hendrik Jan De Graaf, Danielle Walthera Maria Kemper-Van De Wiel, Roland Antonius Johannes Gerardus Smits, Albert Hendrik Jan Immink, Femke Karina De Theije, Wendela Meertens
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Publication number: 20140179024Abstract: The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the presence of one or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one or more analytes and/or analyte analogues.Type: ApplicationFiled: February 26, 2014Publication date: June 26, 2014Inventors: Jeroen Hans NIEUWENHUIS, Ahmed Mohammed Taki JEHANLI, Femke Karina DE THEIJE, Eduard Gerard Marie PELSSERS
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Publication number: 20140127713Abstract: The invention provides means for making examinations on a sample of body fluid, particularly a sample of blood. The presence of at least one characteristic protein is additionally detected, and the intended examinations are only executed and/or evaluated if said characteristic protein is present. The characteristic protein may for example be human serum albumin or hemoglobin if the body fluid is blood. Preferably, the characteristic protein is quantitatively detected in a competitive assay performed in a cartridge (110) with the help of a sensor device (150).Type: ApplicationFiled: June 4, 2012Publication date: May 8, 2014Inventors: Femke Karina De Theije, Albert Hendrik Jan Immink, Lian Van Lippen, Franka Maria Diny Couwenberg
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Publication number: 20120107961Abstract: A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40?).Type: ApplicationFiled: June 24, 2010Publication date: May 3, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Wendy Uyen Dittmer, Femke Karina De Theije, Albert Hendrik Jan Immink, Jeroen Hans Nieuwenhuis, Petrus Johannes Wilhelmus Van Lankvelt
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Publication number: 20110065211Abstract: The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the presence of one or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one or more analytes and/or analyte analogues.Type: ApplicationFiled: May 26, 2009Publication date: March 17, 2011Applicants: KONINKLIJKE PHILIPS ELECTRONICS N.V., COZART LIMITEDInventors: Jeroen Hans Nieuwenhuis, Ahmed Mohammed Taki Jehanli, Femke Karina De Theije, Eduard Gerard Marie Pelssers